Polymer compositions containing colloids of silver salts

• US 6,716,895 B1
• Filed: 12/15/1999
• Issued: 04/06/2004
• Est. Priority Date: 12/15/1999
• Status: Expired due to Term

• Current Assignee: C.R. Bard, Inc. (Becton, Dickinson & Co)
• Original Assignee: C.R. Bard, Inc. (Becton, Dickinson & Co)
• Inventors: Terry, Richard N.
• Primary Examiner(s): SZEKELY, PETER A
• Application Number:
  US09/461,846
• Time in Patent Office: 1,574 Days
• Field of Search: 523/122, 604/264, 604/265, 604/905, 524/403
• US Class Current: 523/122
• CPC Class Codes: A61L 2300/102 Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
• CPC Class Codes: A61L 2300/104 Silver, e.g. silver sulfadiazine
• CPC Class Codes: A61L 2300/404 Biocides, antimicrobial agents, antiseptic agents
• CPC Class Codes: A61L 2300/602 Type of release, e.g. controlled, sustained, slow
• CPC Class Codes: A61L 2300/606 Coatings
• CPC Class Codes: A61L 27/34 Macromolecular materials
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence
• CPC Class Codes: A61L 29/08 Materials for coatings
• CPC Class Codes: A61L 29/16 Biologically active materials, e.g. therapeutic substances A61L29/048 takes precedence
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: A61M 2025/0056 provided with an antibacterial agent, e.g. by coating, residing in the polymer matrix or releasing an agent out of a reservoir
• CPC Class Codes: Y10S 604/905 Aseptic connectors or couplings, e.g. frangible, piercable

Abstract

The present invention relates to antimicrobial compositions, methods for the production of these compositions, and use of these compositions with medical devices, such as catheters, and implants. The compositions of the present invention advantageously provide varying release kinetics for the active ions in the compositions due to the different water solubilities of the ions, allowing antimicrobial release profiles to be tailored for a given application and providing for sustained antimicrobial activity over time. More particularly, the invention relates to polymer compositions containing colloids comprised of salts of one or more oligodynamic metal, such as silver. The process of the invention includes mixing a solution of one or more oligodynamic metal salts with a polymer solution or dispersion and precipitating a colloid of the salts by addition of other salts to the solution which react with some or all of the first metal salts. The compositions can be incorporated into articles or can be employed as a coating on articles such as medical devices.

Claims

1. An article of manufacture comprising a substrate and an antimicrobial polymer coating, wherein the polymer coating comprises one or more polymers and a colloid, wherein the colloid comprises oligodynamic metal compounds, wherein the oligodynamic metal compounds are a plurality of metal salts, a plurality of metal oxides, or a combination of at least one metal salt and at least one metal oxide.

2. The article of claim 1 wherein the article comprises a medical device.

3. The article of claim 2 wherein the medical device comprises a catheter, an endotracheal tube, a tracheostomy tube, a wound drainage device, a wound dressing, a stent, an implant, an intravenous catheter, a medical adhesive, a suture, a shunt, a glove, a condom, a contact lens, a gastrostomy tube, medical tubing, cardiovascular products, heart valves, pacemaker leads, a guidewire, or urine collection devices.

4. The article of claim 2 wherein the medical device is a catheter.

5. The article of claim 1 wherein the polymer comprises one or more hydrophilic polymers that are soluble in water or in an organic solvent containing water, one or more hydrophobic polymers, or a combination of both hydrophilic and hydrophobic polymers.

6. The article of claim 5 wherein the hydrophilic polymer is selected from the group consist of polyurethanes, polyvinylpyrrolidones, polyvinyl alcohols, polyethylene glycols, polypropylene glycols, polyoxyethylenes, polyacrylic acid, polyacrylamide, carboxymethyl cellulose, cellulose, dextrans, polysaccharides, starches, guar, xantham and other gums, collagen, gelatins, biological polymers, and mixtures and copolymers thereof.

7. The article of claim 5 wherein the hydrophobic polymer is selected from the group consisting of polytetrafluoroethylene, polyvinyl chloride, polyvinylacetate, poly(ethylene terephthalate), silicone, polyesters, polyamides, polyureas, styrene-block copolymers, polymethyl methacrylate, polyacrylates, acrylic-butadiene-styrene copolymers, polyethylene, polystyrene, polypropylene, natural and synthetic rubbers, acrylonitrile rubber, and mixtures and copolymers thereof.

8. The article of claim 1 wherein at least one of the oligodynamic metal compounds comprises silver.

9. The article of claim 8 wherein silver is present in a compound selected from the group consisting of silver chloride, silver iodide, silver citrate, silver lactate, silver acetate, silver propionate, silver salicylate, silver bromide, silver ascorbate, silver laurel sulfate, silver phosphate, silver sulfate, silver oxide, silver benzoate, silver carbonate, silver sulfadiazine, silver gluconate, and combinations thereof.

10. The article of claim 1 wherein the oligodynamic metal compounds comprise more than one oligodynamic metal.

11. The article of claim 1 wherein the oligodynamic metal compounds comprise compounds having different solubilities in water.

12. The article of claim 11 wherein the oligodynamic metal compounds comprise silver lactate, silver acetate, silver citrate, silver chloride, and silver iodide.

20. The article of claim 1, wherein the coating is located on one or more exposed surfaces of the articles.

21. The article of claim 1, wherein the article will release at lease some oligodynamic metal into aqueous fluids that come into contact with an exposed surface of the article.

13. An article of manufacture comprising a composition comprising one or more polymers and a colloid wherein the colloid comprises oligodynamic metal compounds, wherein the oligodynamic metal compounds are a plurality of metal salts, a plurality of metal oxides, or a combination of at least one metal salt and at least one metal oxide.

14. A method for the manufacture of an article comprising applying a coating composition to a substrate by spraying the coating composition onto the substrate or by dipping the substrate into the coating composition, wherein the coating composition comprises polymers, monomers, or any combination thereof, and a colloid, wherein the colloid comprises oligodynamic metal compounds, wherein the oligodynamic metal compounds are a plurality of metal salts, a plurality of metal oxides, or a combination of at least one salt and at least one metal oxide.

15. A method comprising the steps of:

1) forming a composition that comprises a solution, dispersion, or combination thereof of one or more polymers containing a colloid wherein the colloid comprises oligodynamic metal compounds, wherein the oligodynamic metal compounds are a plurality of metal salts, a plurality of metal oxides, or a combination of at least one metal salt and at least one metal oxide, and

2) drying the composition.

16. The method of claim 15, further comprising processing the dried composition with the application of heat.

17. A method comprising:

1) forming a composition that comprises a solution, dispersion, or combination thereof of one or more polymers containing a colloid wherein the colloid comprises oligodynamic metal compounds, wherein the oligodynamic metal compounds are a plurality of metal salts, a plurality of metal oxides, or a combination of at least one metal salt and at least one metal oxide;

2) compounding the composition formed in (1) with one or more polymers; and

3) processing the composition formed in (2) with the application of heat.

18. A method for the manufacture of an article comprising dipping a form in a composition comprising polymers, monomers, or any combination thereof, and a colloid comprising oligodynamic metal compounds, wherein the oligodynamic metal compounds are a plurality of metal salts, a plurality of metal oxides, or a combination of at least one metal salt and at least one metal oxide.

19. A method for the manufacture of an article comprising casting a composition comprising polymers, monomer, or any combination thereof, and a colloid comprising oligodynamic metal compounds, wherein the oligodynamic metal compounds are a plurality of metal salts, a plurality of metal oxides, or a combination of at least one metal salt and at least one metal oxide.

22. An article of manufacture comprising a substrate and an antimicrobial polymer coating located on one or more exposed surfaces of the article, wherein:

the polymer coating comprises one or more polymers and a colloid, wherein the colloid comprises one or more oligodynamic metal compounds, wherein the oligodynamic metal compounds are at least one metal salt, at least one metal oxide, or a combination of at least one metal salt and at least one metal oxide; and

the article comprises a medical device.

23. The article of claim 22 wherein the article will release at least some oligodynamic metal into aqueous fluids that come into contact with an exposed surface of the article.

24. The article of claim 22 wherein the article comprises a catheter, an endotracheal tube, a tracheostomy tube, a wound drainage device, a wound dressing, a stent, an implant, an intravenous catheter, a medical adhesive, a suture, a shunt, a glove, a condom, a contact lens, a gastrostomy tube, medical tubing, cardiovascular products, a heart valve, a pacemaker lead, a guidewire, or urine collection devices.

25. The article of claim 22 wherein the article is a catheter.

26. The article of claim 22 wherein the polymer comprises one or more hydrophilic polymers that are soluble in water or in an organic solvent containing water, one or more hydrophobic polymers, or a combination of both hydrophilic and hydrophobic polymers.

27. The article of claim 26 wherein the hydrophilic polymer is selected from the group consisting of polyurethanes, polyvinylpyrrolidones, polyvinyl alcohols, polyethylene glycols, polypropylene glycols, polyoxyethylenes, polyacrylic acid, polyacrylamide, carboxymethyl cellulose, cellulose, dextrans, polysaccharides, starches, guar, xantham and other gums, collagen, gelatins, biological polymers, and mixtures and copolymers therof.

28. The article of claim 26 wherein the hydrophobic polymer is selected from the group consisting of polytetrafluoroethylene, polyvinyl chloride, polyvinlacetate, poly(ethylene terephthalate), silicone, polyesters, polyamides, polyureas, strene-block copolymers, polymethyl methacrylate, polyacrylates, acrylic-butadiene-styrene copolymers, polyethylene, polystrene, polypropylene, natural and synthetic rubbers, acrylonitrile rubber, and mixtures and copolymers thereof.

29. The article of claim 22 wherein at least one of the oligodynamic metal compounds comprises silver.

30. The article of claim 29 wherein silver is present in a compound selected from the group consisting of silver chloride, silver iodide, silver citrate, silver lactate, silver acetate, silver propionate, silver salicylate, silver bromide, silver ascorbate, silver laurel sulfate, silver phosphate, silver sulfate, silver oxide, silver benzoate, silver carbonate, silver sulfadiazine, silver gluconate, and combinations thereof.

31. The article of claim 22 wherein the oligodynamic metal compounds comprise more than one oligodynamic metal.

32. The article of claim 22 wherein the oligodynamic metal compounds comprise compounds having different solubilities in water.

33. The article of claim 32 wherein the oligodynamic metal compounds comprise silver lactate, silver acetate, silver citrate, silver chloride, and silver iodide.

34. A method for the manufacture of an article comprising:

applying a coating composition to a substrate by spraying the coating composition onto the substrate or by dipping the substrate into the coating composition wherein the coating composition comprises polymers, monomers, or any combination thereof, and a colloid, wherein the colloid comprises one or more oligodynamic metal compounds, wherein the oligodynamic metal compounds are at least one metal salt, at least one metal oxide, or a combination of at least one metal salt and at least one metal oxide; and

,

allowing the coating composition to form a covering on an exposed surface of the substrate;

wherein the article comprises a medical device.

35. A method comprising the steps of:

1) forming a composition that comprises a solution, dispersion, or combination thereof of one or more polymers containing a colloid wherein the colloid comprises one or more oligodynamic metal compounds, wherein the one or more oligodynamic metal compounds are at least one metal salt, at least one metal oxide, or a combination of at least one metal salt and at least one metal oxide; and

2) drying the composition;

wherein the method results in formation of a medical device comprising the composition located on at least one exposed surface.

36. The method of claim 35, further comprising processing the dried composition with the application of heat.

37. A method for the manufacture of an article comprising:

1) forming a composition that comprises a solution, dispersion, or a combination thereof of one or more polymers containing a colloid wherein the colloid comprises one or more oligodynamic metal compounds, wherein the oligodynamic metal compounds are at least one metal salt, at least one metal oxide, or a combination of at least one metal salt and at least one metal oxide;

2) compounding the composition formed in (1) with one or more polymers; and

3) processing the composition formed in (2) with the application of heat;

wherein the article comprises a medical device and the composition formed in step (2) is located on at least one exposed surface of the article.

38. A method for the manufacture of an article comprising dipping a form in a composition comprising polymers, monomers, or any combination thereof and a colloid comprising one or more oligodynamic metal compounds, wherein:

the oligodynamic metal compounds are at least one metal salt, at least one metal oxide, or a combination of at least one metal salt and at least one metal oxide;

the composition is located on at least one exposed surface of the article; and

,

the article comprises a medical device.

39. A method for the manufacture of an article comprising casting a composition comprising polymers, monomers, or any combination thereof, and a colloid comprising one or more oligodynamic metal compounds, wherein:

the oligodynamic metal compounds are at least one metal salt, at least one metal oxide, or a combination of at least one metal salt and at least one metal oxide;

the composition is located on at least one exposed surface of the article; and

,

the article comprises a medical device.

40. An article of manufacture comprising a substrate and an antimicrobial polymer coating located on one or more exposed surfaces of the article, wherein:

the polymer coating comprises a polyvinyl chloride, a polyurethane-urea block copolymer and a colloid;

the substrate comprises a polyvinyl chloride;

the colloid comprises silver chloride; and

the article comprises an endotracheal tube.

41. An article of manufacture comprising a substrate and an antimicrobial polymer coating located on one or more exposed surfaces of the article, wherein:

the polymer coating comprises a polyurethane-urea block copolymer, silver nitrate, and a colloid;

the substrate comprises latex;

the colloid comprises silver chloride; and

the article comprises a Foley catheter.

42. An article of manufacture comprising a composition comprising one or more polymers and a colloid wherein the colloid comprises one or more oligodynamic metal compounds, wherein:

the oligodynamic metal compounds are at least one metal salt, at least one metal oxide, or a combination of at least one metal salt and at least one metal oxide;

at least some of the composition is located at an exposed surface of the article; and

the article comprises a medical device.

43. An article of manufacture comprising a substrate and an antimicrobial polymer coating located one one or more exposed surfaces of the article, wherein:

the polymer coating comprises one or more polymers and a colloid, wherein the colloid comprises one or more oligodynamic metal salts; and

the article comprises a medical device.

44. An article of manufacture comprising a substrate and an antimicrobial polymer coating, wherein the polymer coating comprises one or more polymers and a colloid, wherein the colloid comprises a plurality of oligodynamic metal salts.

45. An article of manufacture comprising a composition comprising one or more polymers and a colloid wherein the colloid comprises a plurality of oligodynamic metal salts.

46. An article of manufacture comprising a composition comprising one or more polymers and a colloid wherein the colloid comprises one or more oligodynamic metal salts, wherein:

at least some of the composition is located at an exposed surface of the article; and

the article comprises a medical device.

47. A method for the manufacture of an article comprising applying a coating composition to a substrate by spraying the coating composition onto the substrate or by dipping the substrate into the coating composition, wherein the coating composition comprises polymers, monomers, or any combination thereof, and a colloid, wherein the colloid comprises a plurality of oligodynamic metal salts.

48. A method for the manufacture of an article comprising:

applying a coating composition to a substrate by spraying the coating composition onto the substrate or by dipping the substrate into the coating composition wherein the coating composition comprises polymers, monomers, or any combination thereof, and a colloid, wherein the colloid comprises at least one oligodynamic metal salt; and

,

allowing the coating composition to form a covering on an exposed surface of the substrate;

wherein the article comprises a medical device.