Process for making paroxetine
First Claim
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1. A process for the preparation of 4-aryl-piperidines of structure (1):
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in which R is hydrogen or an alkyl, aralkyl, aryl, acyl, alkoxycarbonyl, arylalkoxycarbonyl, aryloxycarbonyl group; and
Z′
is a 3,4-methylenedioxyphenyl group;
which process comprises converting a compound of structure (4c) or (4d);
in which R is hydrogen or an alkyl, aralkyl, aryl, acyl, alkoxycarbonyl, arylalkoxycarbonyl, aryloxycarbonyl group; and
X is hydrogen or from one to four reducible groups;
into a compound of structure (1).
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Abstract
Compounds of structure (1) are obtained by reduction of compounds of the structures:
Compounds of structure (1), especially where Z is a hydrogen atom or a 3,4-methylenedioxyphenyl group, are important intermediates for inter alia paroxetine.
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Citations
1 Claim
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1. A process for the preparation of 4-aryl-piperidines of structure (1):
-
in which R is hydrogen or an alkyl, aralkyl, aryl, acyl, alkoxycarbonyl, arylalkoxycarbonyl, aryloxycarbonyl group; and
Z′
is a 3,4-methylenedioxyphenyl group;
which process comprises converting a compound of structure (4c) or (4d);
in whichR is hydrogen or an alkyl, aralkyl, aryl, acyl, alkoxycarbonyl, arylalkoxycarbonyl, aryloxycarbonyl group; and
X is hydrogen or from one to four reducible groups;
into a compound of structure (1).
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Specification