Method and apparatus for measuring blood pressure by the oscillometric technique

• US 6,719,703 B2
• Filed: 06/15/2001
• Issued: 04/13/2004
• Est. Priority Date: 06/15/2001
• Status: Active Grant

• Current Assignee: VSM Medtech Devices Inc.
• Original Assignee: VSM Medtech, Ltd.
• Inventors: Zorn, Anton Bogdan, Strange, Kevin Daryl, Chen, Yunquan
• Primary Examiner(s): PELHAM, JOSEPH MOORE
• Application Number:
  US09/882,908
• Publication Number:
  US 20030045801A1
• Time in Patent Office: 1,033 Days
• Field of Search: 600/490-496, 600/500-503
• US Class Current: 600/494
• CPC Class Codes: A61B 5/022 by applying pressure to close blood vessels, e.g. against the skin; Ophthalmodynamometers
• CPC Class Codes: A61B 5/02225 using the oscillometric method

Abstract

A method and apparatus for measuring blood pressure by the oscillometric technique. The method incorporates variable PIP'"'"'s. The method comprises the steps of obtaining a value for the peak amplitude A_max of an oscillometric envelope; determining a cuff pressure, CP, which corresponds in time with A_max, this pressure representing the MAP of the subject; computing a variable value PIP_SBP as a function of MAP; performing the calculation A_sbp=A_max*PIP_SBP to determine a systolic amplitude value A_sbp along the oscillometric envelope; and determining the cuff pressure C which corresponds in time to A_sbp, this value representing the systolic blood pressure (SBP) of the subject. PIP can be calculated using a piece-wise linear, polynomial, exponential or other function.

Claims

1. A method for calculating the systolic blood pressure of a subject using the oscillometric technique, the method comprising:

a) obtaining a value for the peak amplitude A_max of an oscillometric envelope;

b) determining a cuff pressure, CP, which corresponds in time with A_max, this pressure representing the MAP of the subject;

c) computing a variable value PIP_SBP as a function of MAP;

d) performing the calculation A_sbp=A_max*PIP_SBP to determine a systolic amplitude value A_sbp along the oscillometric envelope; and

e) determining the cuff pressure C which corresponds in time to A_sbp, this value representing the systolic blood pressure (SBP) of the subject.

9. The method claimed in any of claims 1, 2, 5, or 8 wherein:

a) if (MAP≦

A), then PIP_SBP=α

, A and α

being constants;

b) else if (MAP≧

B), then PIP_SBP=β

;

B and β

being constants; and

c) else PIP_SBP=α

−

(γ

*(MAP−

A)),

γ

being a constant equal to $\left(\frac{\mathrm{\alpha <br><br>}-\mathrm{\beta <br><br>}}{B-A}\right).$

10. The method of claim 9, wherein:

a) A is between 90 and 110 mmHg;

b) α

is between 0.5 and 0.66;

c) B is between 130 and 150 mmHg; and

d) β

is between 0.30 and 0.46.

11. The method claimed in claim 10 wherein:

a) A is 100 mmHg, and α

is 0.58; and

b) B is 140 mmHg, β and

0.38.

12. The method claimed in any of claims 1, 2, 5, or 8 wherein PIP_SBP is calculated as follows:

${\mathrm{PIP}}_{\mathrm{SBP}}=A-\frac{B}{1+{\mathrm{Ce}}^{\left(D\times <br><br>\mathrm{MAP}\right)}}$

A, B, C, and D being constants where;

A is between 0.50 and 0.66;

B is between 0.04 and 0.36;

C is between 400 and 4.3×

10¹⁵; and

D is between −

0.30 and −

0.05.

13. The method of claim 12 wherein C and D are related by the equation $C=(\frac{1}{e^{(D\times }}$

E))

where E is a constant between 110 and 130.

14. The method of claim 12 wherein:

a) A is 0.58;

b) B is 0.2;

c) C is 540,000; and

d) D is −

0.11.

15. The method claimed in any of claims 1, 2, 5, or 8 wherein PIP_SBP is calculated as follows:

16. The method of claim 15 wherein

a) A is 6.00×

10<sup>−

7</sup>;

b) B is −

2.09×

10<sup>−

4</sup>;

c) C is 2.06×

10<sup>−

2</sup>; and

e) D is −

3.22×

10<sup>−

2</sup>.

21. The method of claims 1, 2, 5 or 8 wherein PIP_SBP is calculated as a function of MAP, the function producing a curve wherein PIP_SBP is relatively constant when MAP is in the range of between 50-100 mmHg, and is also relatively constant when MAP is in the range of between 140-180 mmHg.

22. The method of claim 21 wherein PIP_SBP has a value of:

a) 0.58±

0.08 when 50 mmHg≦

MAP≦

100 mmHg;

b) 0.38±

0.08 when 140 mmHg≦

MAP≦

180 mmHg; and

c) an intermediate value when 100 mmHg≦

MAP≦

140 mmHg.

2. A method for measuring blood pressure, comprising:

a) placing a blood pressure cuff around the limb of a subject, inflating it, and monitoring the pressure within said cuff as said cuff is slowly deflated;

b) collecting Time, Cuff pressure and Pressure pulse amplitude data during this deflation time;

c) representing said Time, Cuff pressure and Pressure pulse amplitude data in a pressure versus time waveform;

d) from this pressure versus time waveform, deriving an oscillating component due to blood pressure pulses;

e) representing said oscillating component by an oscillometric envelope;

f) obtaining a value for the peak amplitude A_max of said oscillometric envelope;

g) determining a cuff pressure CP which corresponds in time with A_max, this pressure representing the mean arterial pressure (MAP) of the subject;

h) calculating a PIP_SBP value from said MAP pressure;

i) performing the calculation A_sbp=A_max*PIP_SBP to determine a systolic amplitude value A_sbp along said oscillometric envelope;

j) determining the cuff pressure C which corresponds in time to A_sbp; and

k) displaying cuff pressure C, this value representing the systolic blood pressure (SBP) of the subject.

3. A system for measuring blood pressure by the oscillometric technique, said system comprising:

a) a microprocessor;

b) a program memory accessible by said microprocessor;

c) a first software program component stored within said program memory for operating said microprocessor;

d) a data memory connected to said microprocessor for storing data from said microprocessor;

e) a blood pressure measurement subsystem acting under the control of said first software program component, said subsystem acquiring once per sample period, and providing to said microprocessor, an instantaneous pressure value representing the blood pressure within a blood pressure cuff placed on a subject;

f) a second software program component stored within said program memory for extracting, from said instantaneous pressure value, data relating to time T, cuff pressure C and a pulse amplitude A, said time, pressure and amplitude data stored by said microprocessor into said data memory;

g) a systolic blood pressure determiner comprising a third software program component for determining MAP from said time, pressure and amplitude data, for determining PIPs from said MAP, and for determining SBP and DBP values from said PIPs; and

h) a user interface allowing a user to provide input to said system and to receive output from said system.

4. The blood pressure measuring system of claim 3, wherein said first, second and third software program components are contained within a single software program.

5. A method for determining a blood pressure of a subject, the method comprising:

a) using an oscillometric technique to obtain oscillometric data;

b) estimating mean arterial pressure (MAP), or estimating systolic blood pressure (SBP) from said oscillometric data;

c) determining PIP_SBP, PIP_DBP, or both PIP_SBP, and PIP_DBP values as functions of estimated MAP or estimated SBP; and

d) using said PIP_SBP and/or PIP_DBP values in an oscillometric technique to determine SBP and/or DBP.

6. The method claimed in claim 5 wherein MAP is obtained by:

a) obtaining an oscillometric envelope from the oscillometric data;

b) finding a peak value A_max of said oscillometric envelope; and

c) obtaining an estimated mean arterial pressure (MAP) by determining a cuff pressure which corresponds in time with A_max.

7. The method claimed in claim 5 wherein the estimated SBP is obtained in a way in which systolic pressure is typically obtained in the standard oscillometric technique in which a fixed PIP is used.

8. A method for measuring blood pressure, comprising the steps of:

a) applying a blood pressure cuff around a limb of a subject, inflating said cuff to occlude the flow of blood in that limb, and then deflating the cuff while collecting Cuff Pressure Data;

b) extracting Pulse Amplitudes from said Cuff Pressure Data, the Pulse Amplitudes comprising the oscillating component due to the blood pressure pulse;

c) representing the sequence of said Pulse Amplitudes by an envelope;

d) obtaining a peak value of said envelope, A_max;

e) determining a cuff pressure which corresponds in time with A_max, this pressure being an estimate of the mean arterial pressure (MAP) of the subject;

f) determining the PIP_SBP, PIP_DBP, or both PIP_SBP and PIP_DBP values from said MAP pressure; and

g) determining the systolic blood pressure according to said PIP_SBP, or the diastolic pressure according to said PIP_DBP.

17. An apparatus for measuring blood pressure, said apparatus comprising:

a) a microprocessor;

b) a program memory accessible by said microprocessor;

c) a first software program component stored within said program memory;

d) a data memory connected to said microprocessor;

e) a blood pressure measurement subsystem acting under the control of said first software program component, said subsystem periodically acquiring, and providing to said microprocessor, instantaneous pressure values representing the pressure within a blood pressure cuff placed on a subject, and storing said values from said microprocessor in said data memory;

f) a second software program component stored within said program memory for extracting, from plurality of said instantaneous pressure values, data relating to pulse amplitudes A and their corresponding cuff pressures C, said A and C data stored by said microprocessor into said data memory;

g) a third software program component stored within said program memory for determining the MAP from said A and C data;

h) a fourth software program component stored within said program memory for determining the PIPs based on said MAP; and

i) a fifth software program component stored within said program memory for determining the SBP and DBP based on said PIPs and said A and C data.

18. The apparatus of claim 17, wherein said first, second, third, fourth and fifth software program components are contained within a single software program.

19. An apparatus for measuring blood pressure, said apparatus comprising:

a) means for collecting TAC data from a subject;

b) means for determining MAP of said subject from said TAC data;

c) means for determining PIP_SBP, and optionally PIP_DBP, as a function of said MAP; and

d) means for computing SBP, and optionally DBP, from said PIP_SBP and said PIP_DBP values, respectively.

20. A method for measuring blood pressure, comprising the steps of:

a) applying a blood pressure cuff around a limb of a subject, inflating said cuff to occlude the flow of blood in that limb, and then deflating the cuff while collecting Cuff Pressure Data;

b) extracting from said Cuff Pressure Data the Pulse Amplitudes, which are the oscillating component due to the blood pressure pulse;

c) representing the sequence of said discrete Pulse Amplitudes by an oscillometric envelope;

d) obtaining a reference point on said envelope;

e) computing PIP_SBP and, optionally, PIP_DBP values from said reference point; and

f) determining a reference time point corresponding to PIP_SBP and, optionally, PIP_DBP; and

g) determining a cuff pressure value corresponding to said reference time point.