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Non-invasive tissue glucose level monitoring

  • US 6,721,582 B2
  • Filed: 02/20/2001
  • Issued: 04/13/2004
  • Est. Priority Date: 04/06/1999
  • Status: Expired due to Fees
First Claim
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1. A non-invasive glucose monitoring instrument comprising:

  • a radiation source for directing excitation radiation to a portion of a tissue surface wherein said source emits excitation radiation at a plurality of different wavelengths of ultraviolet or visible light that excites a target to emit radiation, such that the radiation emitted from the excited target and received at the tissue surface correlates with a glucose level of the tissue;

    a radiation detector positioned to receive the radiation emitted from the tissue surface, wherein the radiation detector is configured to synchronously scan radiation emitted by the target with the excitation radiation; and

    analyzing means operatively connected to the radiation detector for analyzing radiation detected by the radiation detector and translating said detected radiation to an indication of the tissue glucose level, wherein the target is selected from the group consisting of a structural matrix tissue component, a cellular tissue component, a mitochondrial tissue component, a collagen cross link, a pepsin-digestible collagen cross link, a collagenase-digestible collagen cross link, a non-pepsin digestible collagen cross link, an elastin cross link, a tryptophan-containing protein, NADH, FAD a flavoprotein, and any combination thereof.

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