Method and apparatus for non-invasive analysis of blood glucose

• US 6,723,048 B2
• Filed: 06/24/2002
• Issued: 04/20/2004
• Est. Priority Date: 12/28/1999
• Status: Expired due to Term

• Current Assignee: RF Science & Technology, Inc.
• Original Assignee: Pindi Products, Inc.
• Inventors: Fuller, Milton E.
• Primary Examiner(s): Hindenburg, Max F.
• Assistant Examiner(s): Natnithithadha, Navin
• Application Number:
  US10/169,278
• Publication Number:
  US 20020193673A1
• Time in Patent Office: 666 Days
• Field of Search: 600/365, 600/407, 600/409, 600/410, 600/9, 600/10, 600/345, 600/347, 335/302, 335/209, 335/306, 340/854.6, 361/182, 607/101
• US Class Current: 600/365
• CPC Class Codes: A61B 5/05 Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves impedance plethysmography A61B5/0295; measuring movement of the entire body or parts thereof A61B5/11; detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof A61B5/24
• CPC Class Codes: A61B 5/055 involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/6826 Finger
• CPC Class Codes: A61B 5/6838 Clamps or clips
• CPC Class Codes: H01F 7/0273 Magnetic circuits with PM for magnetic field generation

Abstract

An apparatus for non-invasive detection and quantitation of analytes in a sample, such as blood glucose, employs a novel amplifier that uses high-gauss permanent magnets to permit an Rf signal to be transmitted through the sample. The concentration of the analyte can be determined from the magnitude of the reduction in the amplitude of the Rf signal at a characteristic frequency.

Claims

1. An apparatus for substantially noise-free transmission of an Rf signal comprising:

(a) a plurality of spaced-apart permanent magnets that generate a magnetic field;

(b) at least one transmission node, and at least one reflection node spaced apart from the transmission node with a gap therebetween, that are disposed within the magnetic field, the transmission and reflection nodes comprised of an electrically-conductive material;

(c) a source that generates an Rf signal having a selected frequency spectrum that is connected to the transmission node and reflection node, such that a detectable Rf signal is received by the reflection nodes;

(d) an analyzer connected to the transmission node and the reflection node that analyzes the Rf signal received by the reflection node; and

,

(e) a space between the transmission node and reflection node for receiving a sample comprising an analyte, such that an Rf signal having a magnitude at a characteristic frequency is detectable by the analyzer when the sample is placed in the space or receptacle, the magnitude at the characteristic frequency is reduced as a function of analyte concentration.

2. The apparatus of claim 1 wherein the permanent magnets are each grade 26 to grade 60 magnets.

3. The apparatus of claim 2 wherein the permanent magnets are each grade 36 to grade 41 magnets.

4. The apparatus of claim 2 wherein the permanent magnets are each NdFeB magnets.

5. The apparatus of claim 1 wherein the transmission node and reflection node are each in close proximity to one of the magnets.

6. The apparatus of claim 5 comprising a magnetically permeable and electrically insulating barrier disposed between each node and said magnet in close proximity thereto to prevent contact therebetween.

7. The apparatus of claim 1 wherein the source produces an Rf signal having a frequency of about 2 GHz to about 3 GHz.

8. The apparatus of claim 1 wherein the sample is a biological sample.

9. The apparatus of claim 8 wherein the sample is a bodily fluid, tissue, or body part.

10. The apparatus of claim 9 wherein the sample is a finger.

11. The apparatus of claim 1 wherein the analyte includes a biological molecule.

12. The apparatus of claim 11 wherein the analyte is glucose.

13. A method for detecting an analyte in a sample comprising:

(a) providing an apparatus comprising (i) a plurality of spaced-apart permanent magnets that generate a magnetic field;

(ii) at least one transmission node, and at least one reflection node spaced apart from the transmission node with a gap therebetween, that are disposed within the magnetic field, the transmission and reflection nodes comprised of an electrically-conductive material;

(iii) a source that generates an Rf signal having a selected frequency spectrum that is connected to the transmission node and reflection node; and

(iv) an analyzer connected to the transmission node and reflection node;

(b) disposing a sample comprising an analyte between the transmission node and reflection node; and

(c) using the analyzer to detect a reduction in the amplitude of the Rf signal at a frequency that is characteristic of the presence of the analyte.

14. The method of claim 13 further comprising (i) determining the reduction of the amplitude of the Rf signal at the frequency that is characteristic of the presence of the analyte, and (ii) determining the concentration of the analyte on the basis of said reduction of the amplitude.

15. An apparatus for substantially noise-free transmission of an Rf signal comprising:

(a) a plurality of spaced-apart permanent magnets that generate a magnetic field;

(b) at least one transmission node, and at least one reflection node spaced apart from the transmission node with a gap therebetween, that are disposed within the magnetic field, the transmission and reflection nodes comprised of an electrically-conductive material, wherein the transmission node and reflection node are each in close proximity to one of the magnets;

(c) a magnetically permeable and electrically insulating barrier disposed between each node and said magnet in close proximity thereto to prevent contact therebetween; and

,

(d) a source that generates an Rf signal having a selected frequency spectrum that is connected to the transmission node and reflection node, such that a detectable Rf signal is received by the reflection node.

16. The apparatus of claim 15 wherein the permanent magnets are each grade 26 to grade 60 magnets.

17. The apparatus of claim 16 wherein the permanent magnets are each grade 36 to grade 41 magnets.

18. The apparatus of claim 16 wherein the permanent magnets are each NdFeB magnets.

19. The apparatus of claim 15 wherein the source produces an Rf signal having a frequency of about 2 GHz to about 3 GHz.

20. The apparatus of claim 15 further comprising an analyzer connected to the transmission node and the reflection node that analyzes the RF signal received by the reflection node.

21. The apparatus of claim 20 further comprising a space between the transmission rode and reflection node for receiving a sample comprising an analyte, such that an Rf signal having a magnitude at a characteristic frequency is detectable by the analyzer when the sample is placed in the space or receptacle, the magnitude at the characteristic frequency is reduced as a function of analyte concentration.

22. The apparatus of claim 21 wherein the sample comprises a biological sample.

23. The apparatus of claim 22 wherein the sample comprises a bodily fluid, tissue, or body part.

24. The apparatus of claim 23 wherein the sample comprises a finger.

25. The apparatus of claim 21 wherein the analyte includes a biological molecule.

26. The apparatus of claim 25 wherein the analyte is glucose.

27. A detector, which comprises:

a base;

a body part receiver supported by the base;

a pair of nodes positioned at spaced apart locations in the body part receiver to contact a body part positioned in the body part receiver; and

,

a pair of permanent magnets supported by the base, one of said magnets being positioned adjacent one of said nodes, the other of said magnets being positioned adjacent the other of said nodes.

28. The detector as claimed in claim 27, wherein said body part receiver is sized to receive a human digit in contact with said nodes.

29. The detector as claimed in claim 28, wherein said human digit is a finger.

30. The detector as claimed in claim 27, including a magnetically permeable and electrically insulating barrier disposed between each node and said magnet adjacent thereto to prevent contact therebetween.

31. The detector as claimed in claim 27, wherein each node comprises an electrically conducting plate.

32. The detector as claimed in claim 31, wherein each node comprises a gold-plated copper plate.

33. The detector as claimed in claim 27, including a source that generates an Rf signal having a selected frequency spectrum that is coupled to each node.

34. The detector as claimed in claim 33, including an analyzer coupled to each node.

35. The detector as claimed in claim 27, wherein the detector is adapted to detect a characteristic.

36. The detector as claimed in claim 35, wherein the characteristic is an analyte concentration.

37. The detector as claimed in claim 36, wherein the analyte includes a biological molecule.

38. The detector as claimed in claim 36, wherein the analyte comprises glucose.

39. The detector as claimed in claim 36, wherein the analyte comprises a protein.

40. The detector as claimed in claim 36, wherein the analyte comprises hemoglobin Alc.

41. The detector as claimed in claim 36, wherein the analyte comprises a virus.

42. The detector as claimed in claim 36, wherein the analyte comprises an enzyme.

43. The detector as claimed in claim 36, wherein the analyte comprises cholesterol.

44. The detector as claimed in claim 27 wherein the permanent magnets are each grade 26 to grade 60 magnets.

45. The detector as claimed in claim 27 wherein the permanent magnets are each grade 36 to grade 41 magnets.

46. The detector as claimed in claim 27 wherein the permanent magnets are each NJFeB magnets.

47. A method of detecting a characteristic, which comprises:

positioning a body part in a magnetic field;

directing an RF signal having a selected frequency spectrum into said body part positioned in said magnetic field;

analyzing an RF signal received from said body part positioned in said magnetic field to detect a characteristic in said body part.

48. The method as claimed in claim 47, wherein said body part is a human digit.

49. The method as claimed in claim 48, wherein said human digit is a finger.

50. The method as claimed in claim 47, wherein said characteristic includes a concentration of an analyte.

51. The method as claimed in claim 50, wherein said analyte includes a biological molecule.

52. The method as claimed in claim 50, wherein the analyte comprises glucose.

53. The method as claimed in claim 50, wherein the analyte comprises a protein.

54. The method as claimed in claim 50, wherein the analyte comprises hemoglobin Alc.

55. The method as claimed in claim 50, wherein the analyte comprises a virus.

56. The method as claimed in claim 50, wherein the analyte comprises an enzyme.

57. The method as claimed in claim 50, wherein the analyte comprises cholesterol.