Systems and methods for assessing vascular health
First Claim
1. A method of assessing vascular health in a human or an animal, the method of assessing vascular health comprising the steps of:
- obtaining information concerning blood flow within a vessel;
calculating at least two of a mean flow velocity value, a systolic acceleration value, and a pulsatility index value, for the vessel;
correlating at least two of the calculated mean flow velocity value, the calculated systolic acceleration value, and the calculated pulsatility index value; and
assessing the subject'"'"'s vascular health based in part on the correlated values.
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Abstract
The present invention relates generally to systems and methods for assessing blood flow in blood vessels, for assessing vascular health, for conducting clinical trials, for screening therapeutic interventions for adverse effects, and for assessing the effects of risk factors, therapies and substances, including therapeutic substances, on blood vessels, especially cerebral blood vessels, all achieved by measuring various parameters of blood flow in one or more vessels and analyzing the results in a defined manner. The relevant parameters of blood flow include mean flow velocity, systolic acceleration, and pulsatility index. By measuring and analyzing these parameters, one can ascertain the vascular health of a particular vessel, multiple vessels and an individual. Such measurements can also determine whether a substance has an effect, either deleterious or advantageous, on vascular health. The present invention further provides an expert system for achieving the above.
79 Citations
34 Claims
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1. A method of assessing vascular health in a human or an animal, the method of assessing vascular health comprising the steps of:
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obtaining information concerning blood flow within a vessel;
calculating at least two of a mean flow velocity value, a systolic acceleration value, and a pulsatility index value, for the vessel;
correlating at least two of the calculated mean flow velocity value, the calculated systolic acceleration value, and the calculated pulsatility index value; and
assessing the subject'"'"'s vascular health based in part on the correlated values.- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 33)
plotting the pulsatility index value, plotting the systolic acceleration value, and plotting the mean flow velocity value, wherein the pulsatility index value, the systolic acceleration value, and the mean flow velocity value produce a first characteristic value for the vessel.
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3. The method of assessing vascular health in a human or an animal according to claim 1, further comprising the steps of:
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obtaining information concerning an additional variable;
transforming the information into a value, and combining the value with the pulsatility index value, the systolic acceleration value, and the mean flow velocity value, wherein the combined values produce a second characteristic value for the vessel.
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4. The method of assessing vascular health in a human or an animal according to claim 2, further comprising the step of:
comparing the first characteristic value for the vessel to other first characteristic values obtained from measurements of similar vessels in other humans or animals.
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5. The method of assessing vascular health in a human or an animal according to claim 3, further comprising the step of:
comparing the second characteristic value for the vessel to second characteristic values obtained from measurements of similar vessels in other humans or animals.
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6. The method of assessing vascular health in a human or an animal according to claim 1 wherein the vessel is an artery.
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7. The method of assessing vascular health in a human or an animal according to claim 6 wherein the artery supplies a central nervous system.
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8. The method of assessing vascular health in a human or an animal according to claim 6 wherein the artery is at least vessel one selected from the group consisting of common carotid, internal carotid, external carotid, middle cerebral, anterior cerebral, posterior cerebral, anterior communicating, posterior communicating, vertebral, basilar, ophthalmic artery, and branches thereof.
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9. The method of assessing vascular health in a human or an animal according to claim 1 wherein the vessel is an intracranial vessel.
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10. The method of assessing vascular health in a human or an animal according to claim 1, further comprising the steps of:
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using ultrasound energy to collect blood flow information, and using the blood flow information in performing the calculations.
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11. The method of assessing vascular health in a human or an animal according to claim 10, further comprising the step of using a Doppler probe to collect the blood flow information.
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12. The method of assessing vascular health in a human or an animal according to claim 1 wherein the human or the animal has an apparent or suspected vascular disease or a condition that affects vascular function.
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13. The method of assessing vascular health in a human or an animal according to claim 12 wherein the vascular disease or condition is at least one selected from the group consisting of stroke risk, stroke, sleep apnea, and hydrocephalus.
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14. The method of assessing vascular health in a human or an animal according to claim 9 wherein the human or animal has an apparent or suspected vascular disease or condition that affects vascular function.
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15. The method of assessing vascular health in a human or an animal according to claim 14 wherein the vascular disease or condition is at least one selected from the group of stroke risk, stroke, sleep apnea and hydrocephalus.
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16. The method of assessing vascular health in a human or an animal according to claim 1 wherein the human or the animal is analyzed at a time of normal and at a time of abnormal health.
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33. The method according to claim 1 wherein values are calculated with respect to at least three blood vessels in one subject.
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17. A method of assessing cerebrovascular health in a human or an animal, the method of assessing cerebrovascular health comprising the steps of:
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obtaining information concerning blood flow within a blood vessel;
calculating at least two of a mean flow velocity value, a systolic acceleration value, and a pulsatility index value, for the vessel;
inserting at least two of the calculated mean flow velocity value, the calculated systolic acceleration value, and the calculated pulsatility index value into a common schema; and
assessing a subject'"'"'s vascular health based in part on the common schema. - View Dependent Claims (18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 34)
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Specification