Polycarbonate-polyurethane dispersions for thrombo-resistant coatings

• US 6,723,121 B1
• Filed: 09/27/2000
• Issued: 04/20/2004
• Est. Priority Date: 06/18/1997
• Status: Expired due to Term

• Current Assignee: Boston Scientific Scimed (Boston Scientific Corporation)
• Original Assignee: Scimed Life Systems Incorporated (Boston Scientific Corporation)
• Inventors: Zhong, Sheng-Ping
• Primary Examiner(s): Prebilic, Paul B.
• Application Number:
  US09/671,418
• Time in Patent Office: 1,301 Days
• Field of Search: 623/1.46, 623/2.42, 623/66.1, 623/921, 623/926, 606/191, 606/198, 604/266, 427/2.25, 524/389
• US Class Current: 623/1.46
• CPC Class Codes: A61L 33/062 Mixtures of macromolecular compounds
• CPC Class Codes: C08L 75/04 Polyurethanes

Abstract

A coating for a medical device is described which enhances the bio-activity of the surface of a medical device, rendering the surface substantially bio-compatible. The bio-compatible coating is formed from a composition which includes an aqueous emulsion or dispersion of a polycarbonate-polyurethane composition and an excess of polyfunctional cross-linking agent.

Claims

1. A medical device having a surface, said surface having a biocompatible coating formed thereon, the coating having a polyurethane-polycarbonate composition free of organic solvent, the coating containing an internal emulsifying agent with one or more organic acid functional groups and an excess of a polyfunctional cross-linking agent, said medical device adapted for insertion into a mammalian body, said coating formed on an external surface of said medical device.

2. The medical device of claim 1, wherein said one or more organic acid functional groups are selected from the group consisting of fee carboxylic acid, free sulfonic acid, free phosphoric acid and combinations thereof.

3. The medical device of claim 1, wherein said polyfunctional cross-linking agent is selected from the group consisting of polyfunctional aziridines, polyfunctional carbodiimides and combinations thereof.

4. The medical device of claim 1, further comprising a bio-active agent selected from the group consisting of thrombo-resistant agents, anti-tumor agents, growth hormones, antiviral agents, anti-angiogenic agents, angiogenic agents, anti-mitotic agents, anti-inflammatory agents, cell cycle regulating agents, genetic agents, hormones, chemically modified equivalents and combinations thereof.

5. The medical device of claim 1, wherein said surface is selected from the group consisting of polymers, ceramics, metals, glasses and combinations thereof.

6. The medical device of claim 1, wherein said surface is selected from the group consisting of polyethylene, polypropylene, polyvinyl chloride, polytetrafluoroethylene, polyvinyl acetate, polystyrene, poly(ethylene terephthalate), polyurethane, polyurea, silicone rubbers, polyamides, polycarbonates, polyaldehydes, natural rubbers, polyether-ester copolymers, styrene-butadiene copolymers and combinations thereof.