Method and apparatus for detection of a bubble in a liquid

• US 6,723,216 B2
• Filed: 04/29/2002
• Issued: 04/20/2004
• Est. Priority Date: 10/29/1999
• Status: Expired due to Term

• Current Assignee: Radiometer Medical ApS (Danaher Corporation)
• Original Assignee: Radiometer Medical ApS (Danaher Corporation)
• Inventors: Larsen, Allan, Taagaard, Michael
• Primary Examiner(s): Tung, T.
• Application Number:
  US10/134,914
• Publication Number:
  US 20030080002A1
• Time in Patent Office: 722 Days
• Field of Search: 204/401, 204/415, 204/408, 204/400, 205/782, 205/782.5, 205/783, 205/775
• US Class Current: 204/401
• CPC Class Codes: A61M 2230/20 Blood composition characteristics
• CPC Class Codes: G01N 7/00 Analysing materials by measuring the pressure or volume of a gas or vapour

Abstract

A method for detection of a bubble in a liquid which is placed in a measuring chamber and is in contact with a sensor for measuring the partial pressure of a particular gas in a liquid is provided. The method includes performing a first measurement of the partial pressure of the particular gas in the liquid at a first pressure in the measuring chamber. Next, the pressure in the measuring chamber is changed to a second pressure. A second measurement of the partial pressure of the gas in the liquid at the second pressure in the measuring chamber is performed. An expected result of the second measurement based on the first measurement and assuming that no bubbles are present in the measuring chamber during any of the measurements is provided. The actual result of the second measurement is compared with the expected result and a conclusion is drawn on the presence of a gas bubble in the liquid based on the comparison. An apparatus for measuring the content of a particular gas in a liquid is also provided.

Claims

1. A method for detection of a bubble in a liquid which is placed in a measuring chamber and is in contact with a sensor for measuring the partial pressure of a particular gas in the liquid characterized in

(a) performing a first measurement of the partial pressure of the particular gas in the liquid at a first pressure in the measuring chamber,

(b) changing the pressure in the measuring chamber to a second pressure,

(c) performing a second measurement of the partial pressure of said gas in the liquid at the second pressure in the measuring chamber,

(d) providing an expected result of the second measurement based on the first measurement and assuming that no bubbles are present in the measuring chamber during any of the measurements, and

(e) comparing the actual result of the second measurement with the expected result and drawing a conclusion on the presence of a gas bubble in the liquid based on said comparison.

2. The method according to claim 1, characterized in that at least the first measurement is performed over a certain measuring period.

3. The method according to claim 1, characterized in that the expected result is a parameter of a measurement curve representing the signal from the gas measuring sensor during the first measurement.

4. The method according to claim 3, characterized in that the parameter is a slope of the measurement curve.

5. The method according to claim 3, characterized in that the parameter is a level of the measurement curve.

6. The method according to claim 1, characterized in that the expected result is estimated by means of a curve fit on a measurement curve representing the signal from the gas measuring sensor during the first measurement.

7. The method according to claim 1, characterized in that at least the first measurement comprises several distinct measurements performed over the measuring period or a continuous monitoring over said measuring period.

8. The method according to claim 1, characterized in that the pressure change between the first and the second measurement is in the range of 5%-100%.

9. The method according to claim 8, characterized in that the pressure change between the first and the second measurement is in the range of 10%-30%.

10. An apparatus for measuring the content of a particular gas in a liquid comprising a measuring chamber, a sensor connected to the measuring chamber for measuring the partial pressure of said gas in the liquid and for providing at least a first and a second measurement, and means for detecting a bubble in the liquid, characterized in that the means for detecting the bubble in the liquid comprises:

(a) means for changing the pressure in the measuring chamber,

(b) means for providing an expected result of the second measurement based on the first measurement and assuming that no bubbles are present in the measuring chamber during any of the measurements, and

(c) means for comparing an actual result of the second measurement with the expected result.

11. The apparatus according to claim 10, characterized in that the apparatus is an apparatus for blood gas analysis.

12. The apparatus according to claim 10, characterized in that the sensor for measurement of the content of a particular gas in the measuring chamber comprises a pO₂-electrode or a pCO₂-electrode.