Biomaterials for preventing post-surgical adhesions comprised of hyaluronic acid derivatives
First Claim
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1. A composite biomaterial comprised of:
- a benzyl ester of hyaluronic acid, wherein 80% of the carboxyl groups of hylauronic acid are esterified with a benzyl radical and up to 20% of the carboxyl groups are esterified with the alkyl radical of a C10 to C20 aliphatic alcohol, and wherein said biomaterial is in the form of a gel, a flat membrane or mesh, a woven or non-woven tissue, or combinations thereof and wherein said biomaterials prevent the surgical adhesion of tissue.
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Abstract
New biomaterials essentially constituted by esterified derivatives of hyaluronic acid or by cross-linked derivatives of hyaluronic acid for use in the surgical sector, particularly for use in the prevention of post-surgical adhesion.
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Citations
15 Claims
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1. A composite biomaterial comprised of:
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a benzyl ester of hyaluronic acid, wherein 80% of the carboxyl groups of hylauronic acid are esterified with a benzyl radical and up to 20% of the carboxyl groups are esterified with the alkyl radical of a C10 to C20 aliphatic alcohol, and wherein said biomaterial is in the form of a gel, a flat membrane or mesh, a woven or non-woven tissue, or combinations thereof and wherein said biomaterials prevent the surgical adhesion of tissue. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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9. A method for preventing surgical adhesions of tissue which comprises applying to tissue involved in surgery a biomaterial comprised of:
a benzyl ester of hyaluronic acid wherein 80% of the carboxyl groups of hyaluronic acid are esterified with a benzyl radical and up to 20% of the carboxyl groups are esterified with the alkyl radical of a C10 to C20 aliphatic alcohol. - View Dependent Claims (10, 11, 12, 13, 14, 15)
Specification