Method of treating rosacea

• US 6,723,755 B2
• Filed: 05/07/2003
• Issued: 04/20/2004
• Est. Priority Date: 06/12/2002
• Status: Expired due to Term

• Current Assignee: Piotr Chomczynski
• Original Assignee: Piotr Chomczynski
• Inventors: Chomczynski, Piotr
• Primary Examiner(s): Reamer, James H
• Application Number:
  US10/430,917
• Publication Number:
  US 20030232893A1
• Time in Patent Office: 349 Days
• Field of Search: 514/729
• US Class Current: 514/729
• CPC Class Codes: A61K 31/045 Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
• CPC Class Codes: A61K 31/047 having two or more hydroxy groups, e.g. sorbitol
• CPC Class Codes: A61P 17/02 for treating wounds, ulcers, burns, scars, keloids, or the like
• CPC Class Codes: A61P 17/10 Anti-acne agents
• CPC Class Codes: A61P 27/16 Otologicals
• CPC Class Codes: A61P 31/12 Antivirals
• CPC Class Codes: A61P 37/08 Antiallergic agents antiasthmatic agents A61P11/06; ophthalmic antiallergics A61P27/14

Abstract

A method for topically treating rosacea is disclosed. In this method, an active material having the formula given below is applied to the patient at the site of said rosacea:

wherein R¹ is selected from —OH and C₁-C₃ alkyl OH; and R², R³, R⁴, R⁵ and R⁶ are independently selected from —H, —OH, C₁-C₆ alkyl, and C₃-C₆ cycloalkyl. Preferred active materials include 1,2-cyclohexanediol, 1,3-cyclohexanediol, 1,4-cyclohexanediol, and mixtures of those materials. Methods for treating acne vulgaris, as well as colds, flu, sinusitis, and ear infections, using these actives are also disclosed.

Claims

1. A method of treating rosacea in humans comprising topically applying to a patient in need of such treatment a safe and effective amount of the active compound having the following formula, at the site of said rosacea or where said patient is prone to exhibit rosacea:

wherein R¹ is selected from —

OH, and C₁-C₃ alkyl OH; and

R², R³, R⁴, R⁵ and R⁶ are each independently selected from —

H, —

OH, C₁-C₆ alkyl and C₃-C₆ cycloalkyl.

2. The method according to claim 1 wherein the active compound is applied to the skin in an amount of from about 0.05 to about 1 mg/cm².

3. The method according to claim 2 wherein the active compound is applied to the skin in a pharmaceutically-acceptable carrier.

4. The method according to claim 3 wherein the active compound is selected from cyclohexanol, 2-cyclohexylethanol, cyclohexylmethanol, 3-cyclohexyl-1-propanol, 1,4-cyclohexanediol (cis and/or trans isomers), 1,3 cyclohexanediol (cis and/or trans isomers), 1,2-cyclohexanediol, 4-cyclohexylcyclohexanol, 4-methylcyclohexanol, and mixtures thereof.

5. The method according to claim 3 wherein the active compound contains no more than 2 hydroxyl groups.

6. The method according to claim 5 wherein the active compound is selected from 1,2-cyclohexanediol, 1,3-cyclohexanediol, 1,4-cyclohexanediol, and mixtures thereof.

7. The method according to claim 3 wherein R², R³, R⁴, R⁵ and R⁶ are independently selected from —

H and —

OH.

8. The method according to claim 3 wherein the pharmaceutical carrier is selected from propylene glycol, water, dimethylisosorbide, and mixtures thereof.

9. The method according to claim 6 wherein the pharmaceutical carrier is selected from propylene glycol, water, dimethylisosorbide, and mixtures thereof.

10. A method of treating acne vulgaris in humans comprising topically applying to a patient in need of such treatment a safe and effective amount of a compound selected from 1,3-cyclohexanediol, 1,4-cyclohexanediol, and mixtures thereof.

11. A method for treating conditions characterized by inflammation and allergy symptoms comprising topically applying to a patient in need of such treatment a safe and effective amount of a compound selected from cyclohexanol, 2-cyclohexylethanol, cyclohexylmethanol, 3-cyclohexyl-1-propanol, 1,4-cyclohexanediol (the cis and/or trans isomers), 1,3-cyclohexanediol (the cis and/or trans isomers), 1,2-cyclohexanediol (the cis and/or trans isomers), 4-cyclohexylcyclohexanol, and 4-methylcyclohexanol (the cis and/or trans isomers), and mixtures thereof.

12. The method according to claim 11 wherein the condition is selected from colds, flu, sinusitis, and ear infections.

13. The method according to claim 12 wherein the compound is selected from cyclohexanol, 1,3-cyclohexanediol, 1,4-cyclohexanediol, and mixtures thereof.