System combining proton beam irradiation and magnetic resonance imaging

• US 6,725,078 B2
• Filed: 01/04/2001
• Issued: 04/20/2004
• Est. Priority Date: 01/31/2000
• Status: Expired due to Term

• Current Assignee: St. Louis University, Viewray Technologies, Inc. (Viewray Incorporated)
• Original Assignee: St. Louis University
• Inventors: Miller, D. Douglas, Bucholz, Richard D.
• Primary Examiner(s): Denion, Thomas
• Assistant Examiner(s): ROBINSON, DANIEL LEON
• Application Number:
  US09/754,852
• Publication Number:
  US 20010049475A1
• Time in Patent Office: 1,202 Days
• Field of Search: 600/410, 600/411, 600/407, 324/307, 324/308, 324/309
• US Class Current: 600/410
• CPC Class Codes: A61B 5/055 involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
• CPC Class Codes: A61B 5/704 Tables
• CPC Class Codes: A61N 2005/1055 using magnetic resonance imaging [MRI]
• CPC Class Codes: A61N 2005/1087 Ions; Protons
• CPC Class Codes: A61N 5/1037 taking into account the movement of the target, e.g. 4D-image based planning
• CPC Class Codes: A61N 5/1049 for verifying the position of the patient with respect to the radiation beam
• CPC Class Codes: A61N 5/1064 for adjusting radiation treatment in response to monitoring
• CPC Class Codes: A61N 5/1067 in real time, i.e. during treatment
• CPC Class Codes: A61N 5/107 in real time, i.e. during treatment

Abstract

A system which coordinates proton beam irradiation with an open magnetic resonance imaging (MRI) unit to achieve near-simultaneous, noninvasive localization and radiotherapy of various cell lines in various anatomic locations. A reference image of the target aids in determining a treatment plan and repositioning the patient within the MRI unit for later treatments. The patient is located within the MRI unit so that the target and the proton beam are coincident. MRI monitors the location of the target. Target irradiation occurs when the target and the proton beam are coincident as indicated by the MRI monitoring. The patient rotates relative to the radiation source. The target again undergoes monitoring and selective irradiation. The rotation and selective irradiation during MRI monitoring repeats according to the treatment plan.

Claims

1. A system for treating a target within a body of a patient, said system comprising:

a radiating apparatus irradiating a treatment volume having a known position;

a patient support supporting the patient such that the target to be treated is located adjacent to the treatment volume;

a scanner scanning the body and creating body images of the body to monitor the position of the target; and

a controller responsive to the monitored position of the target for selectively activating the radiating apparatus to irradiate the target when the target is at least partially coincident with the treatment volume and selectively deactivating the radiating apparatus when the target is not at least partially coincident with the treatment volume.

2. The system of claim 1 wherein the controller selectively activates and deactivates the radiating apparatus in response to operator input.

3. The system of claim 1 wherein the radiating apparatus comprises a proton beam radiating apparatus irradiating with a proton beam the treatment volume.

4. The system of claim 3 wherein the known position of the treatment volume is the location of a Bragg peak for the proton beam.

5. The system of claim 3 wherein the scanner comprises a magnetic resonance imaging scanner.

6. The system of claim 5 wherein the scanner comprises a coil magnet and wherein the radiation is positioned to pass through the coil magnet so that the radiation is constrained by the coil magnet.

7. The system of claim 1 wherein the radiating apparatus includes a radiation source and an attenuator for adjusting the known position of the treatment volume relative to the radiation source.

8. The system of claim 7 wherein the attenuator is a water attenuator.

9. The system of claim 1 wherein the scanner comprises a magnetic resonance imaging scanner.

10. The system of claim 9 wherein the scanner comprises a coil magnet and wherein the radiation is positioned to pass through the coil magnet so that the radiation is constrained by the coil magnet.

11. The system of claim 1 further comprising a reference image indicative of the target to be treated and wherein the controller determines a position of the target by comparing the body images to the reference image, said controller activating the radiating apparatus to irradiate the target when the determined position of the target is at least partially coincident with or adjacent to the known position of the treatment volume.

12. The system of claim 1 wherein the controller includes a positioning device including a position control for moving the patient support and wherein the position control is responsive to the controller to move the patient support so that the time during which the treatment volume and target are at least partially coincident or adjacent is maximized.

13. The system of claim 1 further comprising a respiratory device for determining respiration onset in the patient and wherein the controller is responsive to the device for selectively activating the radiating apparatus in coordination with respiration onset as detected by the device.

14. The system of claim 1 wherein the patient support comprises:

a base frame supporting the patient support;

a pair of upright supporting mechanisms connected to the base frame;

a pair of patient rotation plates connected to the upright supporting mechanism, said patient rotation plates rotatable about a substantially horizontal rotational axis;

a pair of struts connected to the patient rotation plates, said struts adjustable relative to the patient rotation plates in a substantially vertical fashion; and

a platform adapted to support the body of the patient, said platform connected to the struts to rotate about the rotational axis, wherein the platform is adjustably spaced from the rotational axis by the struts such that the target is coaxial with or adjacent to the rotational axis when the body of the patient is on the platform.

15. A system for treating a target within a body of a patient, said system comprising:

a proton beam radiating apparatus having a Bragg peak irradiating a treatment volume having a known position;

a scanner scanning the body and creating body images of the body to determine the position of the target; and

a controller responsive to the scanner for activating the radiating apparatus to irradiate the target when the position of the target as determined by the scanner is at least partially coincident with the known position of the treatment volume and deactivating the radiating apparatus when the position of the target as determined by the scanner is not at least partially coincident with the known position of the treatment volume.

16. A system for treating a target within a body of a patient, said system comprising:

means for irradiating a treatment volume having a known position;

means for supporting the patient such that the target to be treated is located adjacent to the treatment volume;

means for scanning the body and creating body images of the body to monitor the position of the target; and

means responsive to the monitored position of the target for selectively activating the radiating apparatus to irradiate the target when the target is at least partially coincident with the treatment volume and selectively deactivating the radiating apparatus when the target is not at least partially coincident with the treatment volume.

17. A system for treating a target within a body of a patient, said system comprising:

means for radiating having a Bragg peak irradiating a treatment volume having a known position;

means for scanning the body and creating body images of the body to determine the position of the target; and

means, responsive to the means for scanning, for activating the radiating apparatus to irradiate the target when the position of the target, as determined by the means for scanning, is at least partially coincident with the known position of the treatment volume, and for deactivating the radiating apparatus when the position of the target as determined by the means for scanning is not at least coincident with the known position of the treatment volume.