Apparatus for delivering air-borne substances

• US 6,725,859 B1
• Filed: 01/14/1998
• Issued: 04/27/2004
• Est. Priority Date: 01/22/1997
• Status: Expired due to Fees

• Current Assignee: Charles River Laboratories Incorporated (Pathology Associates, Inc.)
• Original Assignee: Charles River Laboratories Incorporated (Pathology Associates, Inc.)
• Inventors: Yeh, Hsu Chi, Rothenberg, Simon J., Greenspan, Bernard J.
• Primary Examiner(s): WEISS JR, JOSEPH
• Application Number:
  US09/006,982
• Time in Patent Office: 2,295 Days
• Field of Search: 128/200.14, 128/207.18, 128/200.23, 128/200.17, 128/204.18, 604/140, 424/438, 119/420
• US Class Current: 128/200.23
• CPC Class Codes: A61M 15/0086 Inhalation chambers

Abstract

Apparatus and methods for delivery of air-borne materials from pulsatile delivery devices by passing the emissions from such devices and air in a coaxial manner through a suitable mixing chamber. Preferred apparatus include a chamber defining an axis of air flow, a plurality of pulsatile delivery devices, an actuator in communication with the devices for selective actuation thereof, and a device for introducing air at a first end of the chamber and for flowing that air substantially along the axis. The pulsatile delivery devices are positioned at the first end of the chamber such that actuation of the devices emits an air-borne substance substantially along the axis of air flow.

Claims

1. An apparatus for delivering air-borne substances, comprising:

a structure comprising a chamber, wherein said chamber defines an axis of air flow;

an air flow device at a first end of said chamber for introducing air and flowing air substantially along said axis;

a plurality of pulsatile delivery devices positioned at said first end of said chamber such that actuation of said devices emits an air-borne substance substantially along said axis; and

an actuator in communication with said delivery devices for selective actuation thereof;

 

wherein;

said pulsatile delivery devices are positioned within a plurality of cassettes;

or

said axis of air flow is substantially perpendicular to the forces of gravity and said apparatus can be rotated about said axis of air flow.

2. The apparatus of claim 1 wherein said chamber is cylindrical.

3. The apparatus of claim 1 wherein said chamber has a length that is about 3 to 20 times its inner diameter.

4. The apparatus of claim 1 wherein said chamber has a length that is about 4 to 10 times its inner diameter.

5. The apparatus of claim 1 wherein said chamber has a length that is about 4 to 6 times its inner diameter.

6. The apparatus of claim 1 wherein said chamber has a length of about 30 to 200 centimeters.

7. The apparatus of claim 1 wherein said chamber has a length of about 60 to 120 centimeters.

8. The apparatus of claim 1 comprising up to about 32 pulsatile delivery devices.

9. The apparatus of claim 1 comprising about 16 pulsatile delivery devices.

10. The apparatus of claim 1 wherein said pulsatile delivery devices are positioned in rows at said first end of said chamber.

11. The apparatus of claim 1 wherein said pulsatile delivery devices are positioned within a plurality of cassettes.

12. The apparatus of claim 1 wherein said air flow device comprises at least one port at said first end of said chamber.

13. The apparatus of claim 1 wherein said port is in communication with a source of air at a pressure that is equal to or greater than atmospheric pressure.

14. The apparatus of claim 1 further comprising a reducing adapter in fluid communication with said chamber at a second end thereof.

15. The apparatus of claim 14 wherein said reducing adapter is conical.

16. The apparatus of claim 14 wherein said chamber has an inner diameter and said reducing adapter effects approximately 2 to 40 fold reduction in the cross-sectional area of air flow with respect the to said chamber inner diameter.

17. The apparatus of claim 1 mounted upon a substantially planar base.

18. The apparatus of claim 17 which can be rotated about said axis of air flow.

19. A process for delivering air-borne substances, comprising the steps of:

providing an apparatus comprising;

a cylindrical chamber defining an axis of air flow; and

a plurality of pulsatile delivery devices positioned at said first end of said chamber such that actuation of said devices emits an air-borne substance substantially along said axis;

introducing air into said chamber at a first end thereof such that said air flows substantially along said axis; and

actuating at least one of said delivery devices;

 

wherein;

said delivery devices are actuated at fixed intervals;

or

a plurality of said delivery devices are actuated simultaneously, thereby defining a group and at least two groups are actuated sequentially with respect to each other.

20. The process of claim 19 wherein said air flows with a velocity of about 0.5 to 5 centimeters per second with a total air flow form about 10 to 200 LPM.

21. The process of claim 19 wherein said delivery devices are actuated at fixed intervals.

22. The process of claim 19 wherein said delivery devices are actuated simultaneously.

23. The process of claim 19 wherein a plurality of said delivery devices are actuated simultaneously, thereby defining a group.

24. The process of claim 23 wherein there are a plurality of said groups and said groups are actuated sequentially.

25. The process of claim 24 wherein said groups are actuated at fixed intervals.

26. The process of claim 25 wherein said intervals are about 2 to 180 seconds long.

27. The process of claim 25 wherein said air-borne substance has an average residence time in said chamber which is at least 5 times greater than said intervals.