System for controlling flow through a line during intravenous drug delivery

• US 6,726,656 B2
• Filed: 10/08/2002
• Issued: 04/27/2004
• Est. Priority Date: 08/22/1997
• Status: Expired due to Term

• Current Assignee: Deka Products Limited Partnership
• Original Assignee: Deka Products Limited Partnership
• Inventors: Demers, Jason A., Mandro, Marc A., Grant, Kevin, Manning, Robert, Grinnell, Charles M., Gilbreath, Dennis, Kamen, Dean L., Larkins, William T., Lanigan, Richard
• Primary Examiner(s): Gartenberg, Ehud
• Assistant Examiner(s): FASTOVSKY, LEONID M
• Application Number:
  US10/266,997
• Publication Number:
  US 20030060766A1
• Time in Patent Office: 567 Days
• Field of Search: 604/131, 604/82, 604/30, 604/31, 604/35, 604/65, 604/85, 604/86, 604/87, 604/130, 604/89-92, 604/246, 604/518-520, 604/257, 604/258, 604/262, 604/403, 604/408-410
• US Class Current: 604/131
• CPC Class Codes: A61M 2005/1402 Priming
• CPC Class Codes: A61M 2005/1403 Flushing or purging
• CPC Class Codes: A61M 2005/14208 with a programmable infusion control system, characterised by the infusion program
• CPC Class Codes: A61M 2205/123 with incorporated reservoirs
• CPC Class Codes: A61M 2205/128 with incorporated valves
• CPC Class Codes: A61M 2205/35 Communication
• CPC Class Codes: A61M 2205/8206 battery-operated
• CPC Class Codes: A61M 2206/22 eliminating pulsatile flows, e.g. by the provision of a dampening chamber
• CPC Class Codes: A61M 39/24 Check- or non-return valves
• CPC Class Codes: A61M 5/1409 in series, e.g. first substance passing through container holding second substance, e.g. reconstitution systems needle sets A61M5/162
• CPC Class Codes: A61M 5/1413 Modular systems comprising interconnecting elements
• CPC Class Codes: A61M 5/142 Pressure infusion, e.g. using pumps
• CPC Class Codes: A61M 5/14224 Diaphragm type
• CPC Class Codes: A61M 5/16809 by repeated filling and emptying of an intermediate volume pressure infusion using positive displacement pumps A61M5/142
• CPC Class Codes: A61M 5/16827 controlling delivery of multiple fluids, e.g. sequencing, mixing or via separate flow-paths infusion of multiple fluids without using a controller A61M5/1407
• CPC Class Codes: A61M 5/16831 Monitoring, detecting, signalling or eliminating infusion flow anomalies low-level float-valves causing cut-off A61M5/40; indicating or recording presence, absence or direction of flow in general G01P13/0066
• CPC Class Codes: A61M 5/16854 by monitoring line pressure
• CPC Class Codes: A61M 5/16877 Adjusting flow; Devices for setting a flow rate
• CPC Class Codes: A61M 5/365 Air detectors A61M5/1684 takes precedence; in extracorporeal blood circuits A61M1/3626
• CPC Class Codes: A61M 5/5086 for indicating if defective, used, tampered with or unsterile
• CPC Class Codes: F16K 5/0414 : Plug channel at 90 degrees to the inlet
• CPC Class Codes: F16K 5/0478 : on the plug

Abstract

A system and method for the preparation and delivery of intravenous drugs includes a liquid inlet for connection to a liquid supply and vial receptacles. The system may also include a liquid outlet for providing the intravenous drug in mixed, liquid form to the patient. The system may include a chamber having a variable volume, and a valve mechanism, which may be actuated to control flow between the liquid outlet, the variable-volume chamber, the vial receptacles and the liquid inlet. The liquid inlet, the vial receptacles, the variable-volume chamber, the liquid outlet and the valve mechanism may be located in a disposable cassette, which may be received in a control unit.

Claims

1. A system for controlling flow through an intravenous line, the system comprising:

a disposable cassette having a first valve chamber defined by a first rigid wall and a first flexible membrane, and a second valve chamber defined by a second rigid wall and a second flexible membrane; and

a control unit having a cam, a first actuator disposed adjacent the first flexible membrane so that movement of the first actuator causes a change in pressure on the first flexible membrane, and a second actuator disposed adjacent the second flexible membrane so that movement of the second actuator causes a change in pressure on the second flexible membrane, wherein the cam and actuators are disposed with respect to each other such that, as the cam is rotated, the actuator are moved.

2. The system of claim 1 wherein the cam is shaped so that at any time at least one actuator is urging the corresponding flexible membrane into a closed position.

3. The system of claim 2 wherein the cassette further includes a pressure-conduction chamber located in a fluid passageway between the first and second valve chambers.

4. A system for delivering a dose of medication to a patient, the system comprising:

a cassette having

a variable-volume chamber having an inlet leading from a medication supply and an outlet leading to the patient,

a manifold providing fluid communication between the medication supply and the chamber,

an air vent in fluid communication with the manifold,

an outlet valve controlling flow out of the chamber,

an inlet valve controlling flow between the chamber and the manifold, and

an air valve controlling flow between the air vent and the manifold; and

a control unit having

a device for inducing change in the volume of the chamber,

an apparatus for actuating the outlet valve, the inlet valve and the air valve, and

a controller for controlling the volume-changing device and the valve-actuating apparatus to move fluid back and forth between the supply and the chamber while delivering medication to the patient.

5. A system according to claim 4, wherein the controller includes means for determining whether any air has entered the chamber, and means for forcing the air from the chamber into the manifold.

6. A system according to claim 5, wherein the valve-actuating apparatus includes means for opening the inlet valve only part way.

7. A system for controlling flow through a fluid line, the system comprising:

a first valve chamber defined by a first rigid wall and a first flexible membrane, and a second valve chamber defined by a second rigid wall and a second flexible membrane; and

a control unit having a cam, a first actuator disposed adjacent the first flexible membrane so that movement of the first actuator causes a change in pressure on the first flexible membrane, and a second actuator disposed adjacent the second flexible membrane so that movement of the second actuator causes a change in pressure on the second flexible membrane, wherein the cam and actuators are disposed with respect to each other such that, as the cam is rotated, the actuators are moved.

8. A system according to claim 7 wherein the cam is shaped so that at any time at least one actuator is urging the corresponding flexible membrane into a closed position.

9. A system according to claim 7 further comprising a pressure-conduction chamber located in a fluid passageway between the first and second valve chambers.

10. A system for delivering a dose of medication to a patient, the system comprising:

a variable-volume chamber having an inlet leading from a medication supply and an outlet leading to the patient,

a manifold providing fluid communication between the medication supply and the chamber,

an air vent in fluid communication with the manifold,

an outlet valve controlling flow out of the chamber,

an inlet valve controlling flow between the chamber and the manifold, and

an air valve controlling flow between the air vent and the manifold; and

a control unit having

a device for inducing change in the volume of the chamber,

an apparatus for actuating the outlet valve, the inlet valve and the air valve, and

a controller for controlling the volume-changing device and the valve-actuating apparatus to move fluid back and forth between the supply and the chamber while delivering medication to the patient.

11. A system according to claim 10, wherein the control unit includes means for determining whether any air has entered the chamber, and means for forcing the air from the chamber the manifold.

12. A system according to claim 10, wherein the valve-actuating apparatus includes means for opening the inlet valve only part way.