Air shot mechanism for electronic injection devices

• US 6,726,661 B2
• Filed: 12/10/2002
• Issued: 04/27/2004
• Est. Priority Date: 10/12/1999
• Status: Expired due to Term

• Current Assignee: Novo Nordisk A/S
• Original Assignee: Novo Nordisk A/S
• Inventors: Munk, Jens, Christensen, Lars Hofmann, Aasmul, Denmark Denmark, Ljunggreen, Henrik
• Primary Examiner(s): Doerrler, William C.
• Assistant Examiner(s): Zec, Filip
• Application Number:
  US10/315,871
• Publication Number:
  US 20030083626A1
• Time in Patent Office: 504 Days
• Field of Search: 604/207, 604/208, 604/154, 604/186, 604/187, 604/191
• US Class Current: 604/207
• CPC Class Codes: A61M 2005/3125 specific display means, e.g. to indicate dose setting
• CPC Class Codes: A61M 2005/31588 electrically driven
• CPC Class Codes: A61M 2205/50 with microprocessors or computers
• CPC Class Codes: A61M 5/20 Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically A61M5/142 , A61M5/46 take precedence; hypodermic projectiles F42B12/54
• CPC Class Codes: A61M 5/24 Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic ampoules or carpules A61J1/06
• CPC Class Codes: A61M 5/3146 Priming, e.g. purging, reducing backlash or clearance
• CPC Class Codes: A61M 5/31525 Dosing burettes, pipettes B01L3/02
• CPC Class Codes: A61M 5/31546 Electrically operated dose setting, e.g. input via touch screen or plus/minus buttons
• CPC Class Codes: A61M 5/31566 Means improving security or handling thereof
• CPC Class Codes: A61M 5/31593 Multi-dose, i.e. individually set dose repeatedly administered from the same medicament reservoir
• CPC Class Codes: A61M 5/3202 Devices for protection of the needle before use, e.g. caps A61M5/50 takes precedence; for infusion spikes A61M5/1626; protectors for sharps A61B50/3001
• CPC Class Codes: Y10S 128/919 Syringe, means to protect user

Abstract

Described is an electronic injection device wherein an electronic circuit is designed to work in two alternative modes: an air shot mode and a dose injection mode. When working in the air shot mode a small predetermined air shot dose is pressed out from the ampule when the injection button is actuated. When working in the injection mode, a dose set by operation of the dose setting means is injected by operation of the injection button. The electronic injection device is normally working in the air shot mode but shifts to work in the dose injection mode when it receives a signal indicating that the dose setting means has been operated. The circuit returns to its air shot mode when receiving a signal indicating that the set dose has been injected. This signal can originate either from a switch indicating that the protection cap is mounted or from a switch indicating that the injection button has been pressed.

Claims

1. An electronic injection device, comprising:

a housing containing an electronic circuit into which the size of a set dose can be read by operation of dose setting means,

an injection button which can be operated to inject a set dose,

an ampoule from which the set of medicine can be pressed out through a needle mounted at the distal end of the ampoule by an electrical driven motor when the injection button is operated, and

an air-shot means that when actuated causes an air-shot signal to be sent to the electronic circuit, the electronic circuit actuating the motor to expel a pre-set, non adjustable small air shot dose from the cartridge.

2. The electronic injection device of claim 1, wherein the electronic circuit comprises a display driven by the electronic circuit to show the dose set by operation of the dose setting means.

3. The electronic injection device of claim 1, wherein the injection device further is provided with a cap switch which cap switch is coupled to the electronic circuit to bring information of the on or off condition of the cap switch.

4. The electronic injection device of claim 1, wherein a position indicator is provided which controls the electronic circuit to only perform the administration of an air-shot dose when the position indicator indicates that the device is held vertically with the needle pointing upward.

5. The electronic injection device of claims 1, 2, 3 or 4;

wherein the electronic circuit comprises a memory wherein historical information of doses are stored and which memory can discriminate between expelling of set doses and air-shot doses.

6. The electronic injection device of claim 5, wherein the size of all air shot doses and injection doses are summed in the memory and subtracted from the size of the total content of a new ampoule to leave the memory with an information of the size of the remaining amount of medicine in the ampoule.

7. The electronic injection device of claim 6, wherein the set dose is compared with the remaining amount of medicine in the ampoule.

8. An injection device comprising:

a cartridge of medicament;

a drive mechanism configured to expel medicament from the cartridge;

an electronic control unit that actuates the drive mechanism;

a means for setting a desired dose to be expelled from the cartridge; and

wherein the control mechanism is configured so that at the request of a user the drive mechanism is actuated to expel an a predetermined air shot dose from the cartridge, without the need for the user to select the size of the air shot dose.

9. The device of claim 8, further comprising a button that is electronically connected to the electronic control unit, the button being activate able byte user and upon activation by the user capable of sending the request for the air shot dose to the electronic control unit.

10. The device of claim 8, further comprising an orientation sensor means for sending a signal to the electronic control unit that the device is oriented in a predetermined manner and wherein the air shot dose is expelled only when the device is in the predetermined orientation.

11. The device of claim 9, further comprising an orientation sensor means for sending a signal to the electronic control unit that the device is oriented in a predetermined manner and wherein the air shot dose is expelled only when the device is in the predetermined orientation.

12. The device of claim 10 wherein the processor is configured to keep track of the total volume of medicament in the cartridge originally and to track the used volume from both user set doses and air shot doses, thereby tracking the remaining medicament in the cartridge.

13. A method for priming and injecting a dose of medication from an electronic injection device having an electronic control unit and a drive mechanism for expelling medicament contained within the device, the method comprising:

a. pressing a button to send a signal to an electronic control mechanism to prime the device by expelling a predetermined air-shot dose;

b. actuating the drive mechanism, upon receipt of the signal from step a, to expel a predetermined air shot dose from the cartridge, wherein the size of the dose is automatically, without user intervention, determined by the electronic control unit;

c. setting a predetermined dose of medication to inject;

d. injecting the predetermined dose of medication; and

wherein steps a and b may be performed before or after step c but wherein steps a-c are performed prior to step d; and

wherein the method of steps a-d are repeated.

14. The method of claim 13, further comprises checking whether the device is in a predetermined orientation prior to step b.

15. The method of claim 13, further comprising tracking the volume of medication remaining in the cartridge by substracting each air shot dose and each user selected dose from the original volume of medication.

16. A medication delivery device comprising:

a. a cartridge containing a medication;

b. an electronic control unit;

c. a plurality of buttons connected to the electronic control unit so that a user may interface with the electronic control unit;

d. a motorized drive mechanism for expelling medication from the cartridge;

e. wherein the electronic control unit is configured to accept a dose size from the user and to control the motorized drive mechanism to expel the dose from the cartridge upon receipt of a dosing instruction from the user; and

f. wherein the controller is configured to prime the device prior to injecting the user selected dose, by receiving a command from the user, wherein the command is sent to the control by the user pressing one of the buttons, and wherein the priming occurs by expelling a pro-selected non-user settable air shot dose.

17. The device of claim 16, wherein the controller is configured to prime the device only when the device is in a predetermined orientation.

18. An electronic injection device, comprising:

a housing containing an electronic circuit into which the size of a set dose can be inputted by operation of dose setting means,

an injection button that can be operated to inject a set dose,

an ampoule from which the set of medicine can be pressed out through a needle mounted at the distal end of the ampoule by an electrical driven motor when the injection button is operated,

further comprising a means for driving out a pre-set small air-shot dose from the cartridge with the aid of the motor upon receipt of an air-shot signal from said circuit.

19. The electronic injection device of claim 18, wherein the electronic circuit comprises a display driven by the electronic circuit to show the dose set by operation of the dose setting means.

20. The electronic injection device of claim 18, wherein the injection device further is provided with a cap switch which cap switch is coupled to the electronic circuit to bring information of the on or off condition of the cap switch.

21. The electronic injection device of claim 18, wherein a position indicator is provided which controls the electronic control to only perform the administration of an air-shot dose when the position indicator indicates that the device is held vertically with the needle pointing upward.

22. The electronic injection device of claim 18, 19, 20 or 21, wherein the electronic control comprises a memory wherein historical information of doses are stored and which memory can discriminate between expelling of set doses and air-shot doses.

23. The electronic injection device of claim 22, wherein the size of all air shot doses and injection doses are summed in the memory and subtracted from the size of the total content of a new ampoule to leave the memory with an information of the size of the remaining amount of medicine in the ampoule.

24. The electronic injection device of claim 23, wherein the set dose is compared with the remaining amount of medicine in the ampoule.

25. A method of performing an air-shot in an electronic injection device comprising an electrical motor wherein the method comprises the step of energizing the motor such that the motor drives a mechanical injection mechanism forward to press out a pre-set, non-adjustable air-shot dose from the cartridge.

26. An electronically controlled motorized injection device comprising:

a motorized drive means for expelling medication from the device;

a first circuit for inputting a user selected dose size to be expelled;

a second circuit for priming the device to expel a small predetermined non-adjustable air shot dose;

a third circuit for driving the motorized drive means to expel either the air shot dose or the user selected dose.

27. The device of claim 26, further comprising a fourth circuit for determining whether the device is oriented in a predetermined position and wherein the fourth circuit prevents priming of the device unless the device is oriented in the predetermined position.