Methods and compositions for healing and repair of articular cartilage

• US 6,727,224 B1
• Filed: 01/28/2000
• Issued: 04/27/2004
• Est. Priority Date: 02/01/1999
• Status: Expired due to Term

• Current Assignee: Genetics Institute LLC (Pfizer Inc.)
• Original Assignee: Genetics Institute LLC (Pfizer Inc.)
• Inventors: Zhang, Renwen, Peluso, Diane, Morris, Elisabeth
• Primary Examiner(s): Low, Christopher S. F.
• Assistant Examiner(s): Robinson, Hope A.
• Application Number:
  US09/493,545
• Time in Patent Office: 1,551 Days
• Field of Search: 514/2, 514/12, 514/44, 128/898, 424/93.7, 424/93.21, 424/423, 424/422, 435/402, 435/320.1, 623/11, 606/152
• US Class Current: 514/8.8
• CPC Class Codes: A61K 38/00 Medicinal preparations containing peptides peptides containing beta-lactam rings A61K31/00; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, A61K31/00; ergot alkaloids of the cyclic peptide type A61K31/48; containing macromolecular compounds having statistically distributed amino acid units A61K31/74; medicinal preparations containing antigens or antibodies A61K39/00; medicinal preparations characterised by the non-active ingredients, e.g. peptides as drug carriers, A61K47/00
• CPC Class Codes: A61K 38/1875 Bone morphogenic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
• CPC Class Codes: A61L 2430/06 for cartilage reconstruction, e.g. meniscus
• CPC Class Codes: A61L 27/227 Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
• CPC Class Codes: A61L 27/3608 Bone, e.g. demineralised bone matrix [DBM], bone powder
• CPC Class Codes: A61L 27/3612 Cartilage, synovial fluid
• CPC Class Codes: A61L 27/3654 Cartilage, e.g. meniscus
• CPC Class Codes: A61P 19/00 Drugs for skeletal disorders
• CPC Class Codes: A61P 19/02 for joint disorders, e.g. arthritis, arthrosis
• CPC Class Codes: A61P 19/04 for non-specific disorders of the connective tissue
• CPC Class Codes: C07K 14/51 Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor

Abstract

Methods and compositions are provided for the treatment of articular cartilage defects and disease involving the combination of tissue, such as osteochondral grafts, with active growth factor. The active growth factor is preferably a composition containing at least one bone morphogenetic protein and a suitable carrier. The method results in the regeneration of functional repair of articular cartilage tissue.

Claims

1. A method for regeneration of articular cartilage comprising administering to an area in need of regeneration of said articular cartilage an osteochondral graft having applied thereto a composition consisting essentially of an amount of at least one purified bone morphogenetic protein (BMP) effective for the regeneration of said articular cartilage.

2. The method of claim 1 wherein said BMP is BMP-2.

3. The method of claim 1 further comprising a protein which induces the formation of tendon or ligament tissue.

4. The method of claim 3 wherein said protein which induces the formation of tendon or ligament tissue is selected from the group consisting of BMP-12, BMP-13, members of the BMP-12 subfamily, and MP52.

5. The method of claim 1 wherein said osteochondral graft is osteochondral allograft.

6. The method of claim 1 wherein said osteochondral graft is osteochondral autograft.

7. A composition for regeneration of articular cartilage consisting essentially of an osteochondral graft having applied thereto an amount of at least one purified bone morphogenetic protein (BMP) effective for the regeneration of said articular cartilage.

8. The composition of claim 7 wherein said BMP is BMP-2.

9. The composition of claim 7 further comprising a protein which induces the formation of tendon or ligament-like tissue.

10. The composition of claim 7 wherein said protein which induces the formation of tendon or ligament-like tissue is selected from the group consisting of BMP-12, BMP-13, members of the BMP-12 subfamily, and MP52.

11. The composition of claim 7 wherein said osteochondral graft is osteochondral allograft.

12. The composition of claim 7 wherein said osteochondral graft is osteochondral autograft.

13. A composition for the regeneration of articular cartilage said composition comprising an osteochondral graft having applied thereto an amount of BMP-2 effective for the regeneration of said articular cartilage.