Ultrasonic apparatus and method for providing quantitative indication of risk of coronary heart disease

• US 6,730,035 B2
• Filed: 11/07/2002
• Issued: 05/04/2004
• Est. Priority Date: 06/05/2002
• Status: Expired due to Term

• Current Assignee: Wisconsin Alumni Research Foundation (University of Wisconsin System)
• Original Assignee: Wisconsin Alumni Research Foundation (University of Wisconsin System)
• Inventors: Stein, James H.
• Primary Examiner(s): Jaworski, Francis J.
• Application Number:
  US10/290,421
• Publication Number:
  US 20030229284A1
• Time in Patent Office: 544 Days
• Field of Search: 600/437, 600/443, 600/449, 600/453-456, 128/921-924
• US Class Current: 600/449
• CPC Class Codes: A61B 5/02007 Evaluating blood vessel condition, e.g. elasticity, compliance
• CPC Class Codes: A61B 8/0858 involving measuring tissue layers, e.g. skin, interfaces

Abstract

An ultrasound machine measures coronary intima-medial thickness and relates it to a statistically derived vascular age. Quantitative risk of coronary heart disease may be calculated using vascular age to substitute for chronological age in publicly available risk assessment data.

Claims

1. A diagnostic ultrasound machine comprising:

an ultrasonic transducer positionable near the carotid artery to obtain echo signals from the carotid artery;

a processing circuit communicating with the ultrasonic transducer and operating to;

(i) process the echo signal to reveal carotid intima-medial thickness (CIMT);

(ii) apply the revealed CIMT to stored first data relating the CIMT to vascular age to determine vascular age

(iii) apply the determined vascular age to stored second data relating vascular age to the quantified risk of heart disease, and

(iv) output the quantified of risk of heart disease.

2. The diagnostic ultrasonic machine of claim 1 wherein the first data is derived from data relating age to CIMT in a study population.

3. The diagnostic ultrasonic machine of claim 2 wherein the data relating age to CIMT is ARIC data.

4. The diagnostic ultrasonic machine of claim 2 wherein multiple CIMT values related to a single age are combined by curve fitting to yield a single vascular age for a single CIMT value.

5. The diagnostic ultrasonic machine of claim 1 wherein the second data is data relating chronological age to quantified risk of heart disease and wherein the first and second data are combined by taking vascular age deduced from the first data set and inputting it as chronological age into the second data set.

6. The diagnostic ultrasonic machine of claim 5 wherein the second data is Framingham data.

7. The diagnostic ultrasonic machine of claim 1 wherein the processing circuit further provides for input of patient data selected from the group consisting of:

chronological age, gender, race and body size and wherein at least one of these patient data are also applied to at least one of the first and second data sets.

8. The diagnostic ultrasonic machine of claim 1 wherein the measure of risk of heart disease is expressed in percent chance of heart disease within ten years.

9. The diagnostic ultrasonic machine of claim 1 wherein the measure of CIMT is an average of carotid intima-medial thickness over a predetermined region of the carotid artery.

10. The diagnostic ultrasonic machine of claim 9 wherein the predetermined region is near the carotid bifurcation.

11. The diagnostic ultrasonic machine of claim 9 wherein the predetermined region is an axial line along the carotid artery.

12. The diagnostic ultrasonic machine of claim 1 wherein the processing circuitry collects a three-dimensional image set of the carotid artery and wherein the predetermined region is a circumferential ring of the carotid artery.

13. The diagnostic ultrasonic machine of claim 1 wherein the processing circuitry provides automatic measurement of the CIMT.

14. The diagnostic ultrasonic machine of claim 1 wherein the processing circuitry further output an image of the carotid artery and accepts user input locating points on the image for the automatic measurement.

15. A diagnostic ultrasound machine comprising:

an ultrasonic transducer positionable near the carotid artery to obtain echo signals from the carotid artery;

a processing circuit communicating with the ultrasonic transducer and operating to;

(i) process the echo signal to reveal carotid intima-medial thickness (CIMT);

(ii) apply the revealed CIMT to stored data relating CIMT of a population to a vascular age indicating statistical derived age of an individual having the revealed CIMT in a standard population; and

(iii) output the vascular age.

16. The diagnostic ultrasonic machine of claim 15 wherein the stored data is derived from data relating age to CIMT in a study population.

17. The diagnostic ultrasonic machine of claim 16 wherein the data relating age to CIMT is ARIC data.

18. The diagnostic ultrasonic machine of claim 16 wherein multiple CIMT values related to a single age are combined by curve fitting to yield a single vascular age for a single CIMT value.

19. The diagnostic ultrasonic machine of claim 15 wherein the processing circuit further provides for input of patient data selected from the group consisting of:

chronological age, gender, race and body size and wherein at least one of these patient data are also applied to the stored data.

20. A method of deducing a quantified risk of heart disease for an individual having a given chronological age and a given carotid intima-medial thickness (CIMT) comprising the steps of:

(a) deducing a vascular age of the individual differing from the given chronological age such as would place the individual'"'"'s given CIMT in a median of CIMT for that vascular age for a standard population;

(b) using the vascular age as an input for chronological age in a Framingham model of heart disease to provide an estimate of cardiac heart disease; and

(c) providing the individual with the vascular age and estimate of cardiac heart disease.