Blood collection systems and methods that derive estimated effects upon the donor's blood volume and hematocrit

• US 6,730,054 B2
• Filed: 02/20/2001
• Issued: 05/04/2004
• Est. Priority Date: 10/16/1999
• Status: Expired due to Term

• Current Assignee: Fenwal Incorporated (Fresenius SE & Co. KGaA)
• Original Assignee: Baxter International Inc.
• Inventors: Pierce, Jennifer A, Foley, John T, Cairone, Robert, Patno, Timothy J
• Primary Examiner(s): Sykes, Angela D.
• Assistant Examiner(s): Deak, Leslie R.
• Application Number:
  US09/789,183
• Publication Number:
  US 20020062100A1
• Time in Patent Office: 1,169 Days
• Field of Search: 210/646, 210/781, 210/782, 604/4.01, 604/5.01, 604/6-1-, 604/6.11
• US Class Current: 604/6.01
• CPC Class Codes: A61M 1/02 Blood transfusion apparatus blood infusion by syringes A61M5/14
• CPC Class Codes: A61M 1/0209 Multiple bag systems for separating or storing blood components
• CPC Class Codes: A61M 1/0222 and filter bypass
• CPC Class Codes: A61M 1/302 having a reservoir for withdrawn untreated blood
• CPC Class Codes: A61M 1/303 having a reservoir for treated blood to be returned
• CPC Class Codes: A61M 1/308 Volume control, e.g. with open or flexible containers, by counting the number of pump revolutions, weighing
• CPC Class Codes: A61M 1/3603 in the same direction
• CPC Class Codes: A61M 1/3633 Blood component filters, e.g. leukocyte filters
• CPC Class Codes: A61M 1/3693 using separation based on different densities of components, e.g. centrifuging
• CPC Class Codes: A61M 1/3696 with means for adding or withdrawing liquid substances during the centrifugation, e.g. continuous centrifugation
• CPC Class Codes: A61M 1/385 taking into account of the patient characteristics
• CPC Class Codes: A61M 2202/0014 removed from the body
• CPC Class Codes: A61M 2202/0021 removed from and reintroduced into the body, e.g. after treatment
• CPC Class Codes: A61M 2202/0427 Platelets; Thrombocytes
• CPC Class Codes: A61M 2202/0429 Red blood cells; Erythrocytes
• CPC Class Codes: A61M 2205/33 Controlling, regulating or measuring
• CPC Class Codes: A61M 2205/3393 by weighing the reservoir
• CPC Class Codes: A61M 2205/60 with identification means
• CPC Class Codes: A61M 2230/207 hematocrit

Abstract

Blood processing systems and methods convey blood drawn from a donor through a blood processing circuit to separate the blood into at least one targeted blood component for collection. The systems and methods derive an estimated effect of the procedure upon the donor. The estimated effect can be expressed in terms of a net blood fluid volume loss, or as a hematocrit of the donor after completion of the desired blood collection procedure. The systems and methods present the estimated effect to an operator for viewing, reading, or offloading.

Claims

1. A blood processing system comprising

a blood processing circuit including an element to separate blood drawn from a donor into at least one targeted blood component, a first container to collect a volume of the targeted blood component, and a second container to dispense a volume of a fluid,

a controller including an input to receive from an operator a desired collection volume for the first container and a desired dispensing volume for the second container, the controller including a first utility function operating to perform a desired blood collection procedure including the steps of conveying blood from the donor through the blood processing circuit, separating the targeted blood component from the blood, collecting a volume of the targeted blood component in the first container, and conveying a volume the fluid from the second container to the donor, the controller including a second utility function operating to derive an estimated effect of the procedure upon the donor by calculating an estimated post-procedure intravascular blood volume deficit for the donor as a function of the desired collection volume for the first container and the desired dispensing volume for the second container, and

an output to present the estimated effect to an operator.

4. A blood processing system according to claim 1 or 3

wherein the fluid dispensed from the second container includes an anticoagulant.

5. A blood processing system according to claim 1 or 3

wherein the fluid dispensed from the second container includes fluid conveyed to the donor as a result of priming the blood processing circuit.

6. A blood processing system according to claim 1 or 2 or 3

wherein the second utility function operates by dividing the calculated estimated post-procedure intravascular blood volume deficit by a blood volume of the donor that existed prior to the desired blood processing procedure.

7. A blood processing system according to claim 1 or 2 or 3

wherein the second utility function operates by dividing the calculated estimated post-procedure intravascular blood volume deficit by weight of the donor.

8. A blood processing system according to claim 1 or 2 or 3

wherein the second utility function operates by calculating a post-procedure hematocrit of the donor as a function of the calculated estimated post-procedure intravascular blood volume deficit.

9. A blood processing system according to claim 1 or 2 or 3

wherein the desired collection volume comprises a volume of red blood cells.

10. A blood processing system according to claim 1 or 2 or 3

wherein the desired collection volume comprises a volume of platelets.

11. A blood processing system according to claim 1 or 2 or 3

wherein the desired collection volume comprises a volume of plasma.

12. A blood processing system according to claim 1 or 2 or 3

wherein the desired collection volume comprises a volume of platelets and a volume of red blood cells.

13. A system according to claim 1 or 2 or 3

wherein the output presents the estimated effect in a visual display.

14. A system according to claim 1 or 2 or 3

wherein the output presents the estimated effect in printed form.

15. A system according to claim 1 or 2 or 3

wherein the output presents the estimated effect in a data form suitable for offloading.

2. A blood processing system comprising

a blood processing circuit having a residual fluid volume and including an element to separate blood drawn from a donor into at least one targeted blood component and a container to collect a volume of the targeted blood component,

a controller including an input to receive from an operator a desired collection volume for the container, the controller including a first utility function operating to perform a desired blood collection procedure including the steps of conveying blood from the donor through the blood processing circuit separating the targeted blood component from the blood, collecting a volume of the targeted blood component in the first container, and conveying a volume the replacement fluid from the second container to the donor, the controller including a second utility function operating to derive an estimated effect of the procedure upon the donor by calculating an estimated post-procedure intravascular blood volume deficit for the donor as a function of the desired collection volume for the container and the residual fluid volume of the blood processing circuit, and

an output to present the estimated effect to an operator.

3. A blood processing system comprising

a blood processing circuit having a residual fluid volume and including an element to separate blood drawn from a donor into at least one targeted blood component, a first container to collect a volume of the targeted blood component, and a second container to dispense a volume of a fluid,

a controller including an input to receive from an operator a desired collection volume for the first container and a desired dispensing volume for the second container, the controller including a first utility function operating to perform a desired blood collection procedure including the steps of conveying blood from the donor through the blood processing circuit, separating the targeted blood component from the blood, collecting a volume of the targeted blood component in the first container, and conveying a volume the fluid from the second container to the donor, the controller including a second utility function operating to derive an estimated effect of the procedure upon the donor by calculating an estimated post-procedure intravascular blood volume deficit for the donor as a function of the desired collection volume for the first container, the desired dispensing volume for the second container, and the residual fluid volume of the blood processing circuit, and

an output to present the estimated effect to an operator.

16. A blood processing method comprising the steps

establishing a blood processing circuit including an element to separate blood drawn from a donor into at least one targeted blood component, a first container to collect a volume of the targeted blood component, and a second container to dispense a volume of a fluid,

designating a desired collection volume for the first container,

designating a desired dispensing volume for the second container,

performing a desired blood collection procedure by conveying blood from the donor through the blood processing circuit, separating the targeted blood component from the blood, collecting a volume of the targeted blood component in the first container, and conveying a volume the fluid from the second container to the donor,

deriving an estimated effect of the procedure upon the donor by calculating an estimated post-procedure intravascular blood volume deficit for the donor as a function of the desired collection volume for the first container and the desired dispensing volume for the second container, and

presenting the estimated effect to an operator.

19. A method according to claim 16 or 18

wherein the fluid conveyed from the second container includes an anticoagulant.

20. A method according to claim 16 or 18

wherein the fluid conveyed from the second container includes a volume of priming fluid conveyed to the donor as a result of priming the blood processing circuit.

21. A method according to claim 16 or 17 or 18

wherein the deriving step includes the step of dividing the calculated estimated post-procedure intravascular blood volume deficit by a blood volume of the donor that existed prior to the desired blood processing procedure.

22. A method according to claim 16 or 17 or 18

wherein the deriving step includes the step of dividing the calculated estimated post-procedure intravascular blood volume deficit by weight of the donor.

23. A blood processing method according to claim 16 or 17 or 18

wherein the deriving step includes the step of calculating a post-procedure hematocrit of the donor as a function of the calculated estimated post-procedure intravascular blood volume deficit.

24. A method according to claim 16 or 17 or 18

wherein the desired collection volume comprises a volume of red blood cells.

25. A method according to claim 16 or 17 or 18

wherein the desired collection volume comprises a volume of platelets.

26. A method according to claim 16 or 17 or 18

wherein the desired collection volume comprises a volume of plasma.

27. A method according to claim 16 or 17 or 18

wherein the desired collection volume comprises a volume of red blood cells and a volume of platelets.

28. A method according to claim 16 or 17 or 18

wherein the presenting step comprises presenting the estimated effect in a visual display.

29. A method according to claim 16 or 17 or 18

wherein the presenting step comprises presenting the estimated effect in printed form.

30. A method according to claim 16 or 17 or 18

wherein the presenting step comprises presenting the estimated effect in a data form suitable for offloading.

17. A blood processing method comprising the steps of

establishing a blood processing circuit having a residual volume and including an element to separate blood drawn from a donor into at least one targeted blood component and a container to collect a volume of the targeted blood component,

designating a desired collection volume for the first container,

performing a desired blood collection procedure by conveying blood from the donor through the blood processing circuit, separating the targeted blood component from the blood, and collecting a volume of the targeted blood component in the container,

deriving an estimated effect of the procedure upon the donor by calculating an estimated post-procedure intravascular blood volume deficit for the donor as a function of the desired collection volume for the first container and the residual fluid volume of the blood processing circuit, and

presenting the estimated effect to an operator.

18. A blood processing method according to claim comprising the steps of

establishing a blood processing circuit having a residual fluid volume and including an element to separate blood drawn from a donor into at least one targeted blood component, a first container to collect a volume of the targeted blood component, and a second container to dispense a volume of a fluid,

designating a desired collection volume for the first container,

designating a desired dispensing volume for the second container,

performing a desired blood collection procedure by conveying blood from the donor through the blood processing circuit, separating the targeted blood component from the blood, collecting a volume of the targeted blood component in the first container, and conveying a volume of the fluid from the second container to the donor, and

deriving an estimated effect of the procedure upon the donor by calculating an estimated post-procedure intravascular blood volume deficit for the donor as a function of the desired collection volume for the first container, the desired dispensing volume of the second container and the residual fluid volume of the blood processing circuit, and

presenting the estimated effect to an operator.