Methods and devices for sealing microchip reservoir devices

• US 6,730,072 B2
• Filed: 05/30/2001
• Issued: 05/04/2004
• Est. Priority Date: 05/30/2000
• Status: Expired due to Fees

• Current Assignee: Massachusetts Institute of Technology
• Original Assignee: Massachusetts Institute of Technology
• Inventors: Santini, John T. Jr., Sheppard, Norman F. Jr., Uhland, Scott A., Herman, Stephen J., Polito, Benjamin F., Shawgo, Rebecca S., Cima, Michael J.
• Primary Examiner(s): Mendez, Manuel
• Assistant Examiner(s): Thompson, Michael M
• Application Number:
  US09/867,976
• Publication Number:
  US 20020151776A1
• Time in Patent Office: 1,070 Days
• Field of Search: 604/890.1, 604/891.1, 604/93.01, 604/20, 604/131, 128/898
• US Class Current: 604/890.1
• CPC Class Codes: A61B 5/03 Detecting, measuring or recording fluid pressure within the body other than blood pressure, e.g. cerebral pressure; Measuring pressure in body tissues or organs A61B5/205 takes precedence
• CPC Class Codes: A61B 5/145 Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissuemeasuring of blood pressure or blood flow A61B5/02; non-radiation detecting or locating of foreign bodies in blood A61B5/06
• CPC Class Codes: A61B 5/14539 for measuring pH
• CPC Class Codes: A61K 9/0009 involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis microelectromechanical systems A61K9/0097
• CPC Class Codes: A61K 9/0097 Micromachined devices; Microelectromechanical systems [MEMS]; Devices obtained by lithographic treatment of silicon; Devices comprising chips intradermal microneedle arrays A61K9/0021; MEMS in general B81B7/02
• CPC Class Codes: A61N 1/303 Constructional details electrodes for external use A61N1/0428
• CPC Class Codes: B01L 2300/0819 Microarrays; Biochips
• CPC Class Codes: B01L 3/50853 with covers or lids

Abstract

Methods and devices are provided for mechanically sealing the reservoirs of microchip devices to prevent leakage from or between any of the reservoirs. In one embodiment, the method includes sandwiching a microchip device and a gasket material covering the reservoir openings between a front sealing frame and a backplate, such that the gasket material is compressed against the back side of the microchip device by the back plate. The front sealing frame is secured to the back sealing plate using fasteners or welding. The gasket material is preferably a flexible polymeric sheet, which is biocompatible and compatible with the reservoir contents. In another embodiment, a composite backplate is used in place of the back sealing plate and separate gasket material. The composite backplate can include a substrate having sealing plugs defined thereon. The composite backplate also can be designed to hold the drug, thereby combining the assembly steps of reservoir filling and sealing.

Claims

1. A microchip device for the release or exposure of molecules or devices, comprising:

a substrate having a front side, a back side, and at least two reservoirs which contain said molecules or devices, the reservoirs having reservoir openings on the back side of the substrate;

a reservoir cap positioned on the front side of the substrate on each reservoir over the molecules or devices, wherein release or exposure of the molecules or devices from the reservoir is controlled by diffusion through or disintegration of the reservoir cap;

a gasket material positioned over the reservoir openings; and

one or more backplates secured over the gasket material to compress the gasket material to the back side of the microchip device to seal the reservoir openings.

2. The device of claim 1, wherein the one or more backplates are secured by mechanical means.

3. The device of claim 1, wherein the one or more backplates are secured with a chemical adhesive, and the gasket material is interposed between the reservoir openings and the chemical adhesive.

4. The device of claim 2, further comprising a front sealing frame secured to the backplate, wherein the substrate and the gasket material are secured between the front sealing frame and the backplate.

5. The device of claim 1, wherein the gasket material is a flexible polymeric sheet.

6. The device of claim 4, wherein the front sealing frame is attached to the back sealing plate with fasteners, crimping, pins/holes, soldering, or welding.

7. The device of claim 6, wherein the fasteners are selected from the group consisting of bolts, rivets, screws, bending tabs, and spring clips.

8. The device of claim 4, wherein the front sealing frame comprises a slotted frame having a slot into which the substrate, the gasket material, and the backplate are secured.

9. The device of claim 1, wherein a two or more substrates are secured between a front sealing frame and said one or more backplate.

10. The device of claim 1, further comprising a barrier layer interposed between the molecules or devices and the gasket material.

11. The device of claim 10, wherein the barrier layer comprises polyethylene glycol.

13. A method for the release or exposure of molecules or devices, comprising:

providing at a site where the molecules or devices are to be delivered the microchip device of claim 1, and

controlling the release or exposure of the molecules or devices from the reservoir by diffusion through or disintegration of the reservoir cap.

12. A microchip device for the release or exposure of molecules or devices, comprising:

a substrate having a front side, a back side, and at least two reservoirs which contain said molecules or devices, the reservoirs having reservoir openings on the back side of the substrate;

a reservoir cap positioned on the front side of the substrate on each reservoir over the molecules or devices, wherein release or exposure of the molecules or devices from the reservoir is controlled by diffusion through or disintegration of the reservoir cap;

one or more backplates secured to the back side of the microchip device; and

a barrier layer positioned between the backplates and the molecules or devices, wherein the backplates and barrier layer cooperate to seal the reservoir openings.

14. A method for sealing reservoirs containing molecules or devices in a microchip device, the method comprising:

providing a microchip device having a front side and a back side, wherein the back side has a plurality of reservoir openings in need of sealing;

positioning a gasket material over the reservoir openings; and

securing one or more backplates over the gasket material to compress the gasket material to the back side of the microchip device so as to seal the reservoir openings.

15. The method of claim 14, wherein the one or more backplates are secured by mechanical means.

16. The method of claim 14, wherein a chemical adhesive is used to secure the one or more backplates, and the gasket material is interposed between the reservoir openings and the chemical adhesive.

17. The method of claim 15, wherein the mechanical means comprises securing the microchip device and the gasket material between a front sealing frame and the backplate.

18. The method of claim 14, wherein the gasket material is a flexible polymeric sheet.

19. The method of claim 17, wherein the front sealing frame is attached to the back sealing plate using fasteners, crimping, pins/holes, soldering, or welding.

20. The method of claim 19, wherein the fasteners are selected from the group consisting of bolts, rivets, screws, bending tabs, and spring clips.

21. The method of claim 19, wherein the welding is selected from the group consisting of laser welding, ultrasonic welding, and solvent welding.

22. The method of claim 17, wherein the front sealing frame comprises a slotted frame having a slot into which the microchip device, the gasket material, and the backplate are secured.

23. The method of claim 17, wherein a plurality of microchip devices are secured within a single front sealing frame.

24. The method of claim 14, further comprising applying a liquid barrier material into the reservoirs which solidifies to form a barrier layer interposed between the molecules or devices and the gasket material.

25. The method of claim 24, wherein the barrier layer comprises polyethylene glycol.