Electronic tongue

• US 6,730,201 B1
• Filed: 09/28/2000
• Issued: 05/04/2004
• Est. Priority Date: 09/28/1999
• Status: Expired due to Fees

• Current Assignee: California Institute of Technology
• Original Assignee: California Institute of Technology
• Inventors: Kuhlman, Kimberly, Buehler, Martin G.
• Primary Examiner(s): Noguerola, Alex
• Application Number:
  US09/670,902
• Time in Patent Office: 1,314 Days
• Field of Search: 204/403.05, 204/403.03, 204/416, 204/418, 204/409, 204/419, 427/2.13
• US Class Current: 204/416
• CPC Class Codes: G01N 27/27 Association of two or more measuring systems or cells, each measuring a different parameter, where the measurement results may be either used independently, the systems or cells being physically associated, or combined to produce a value for a further parameter
• CPC Class Codes: G01N 27/3335 the membrane containing at least one organic component G01N27/3271 takes precedence; aspects concerning the enzyme reagent in enzyme electrodes C12Q1/001

Abstract

An ion selective electrode (ISE) array is described, as well as methods for producing the same. The array can contain multiple ISE which are individually electronically addressed. The addressing allows simplified preparation of the array. The array can be used for water quality monitoring, for example.

Claims

1. A sensor array for the determination of at least one analyte in a liquid sample, the array comprising:

a substrate, comprising a plurality of reference electrodes and a plurality of qel-coated electrodes, each of the gel-coated electrodes coated with a gel layer, the gel layer at least partially coated with a polymer layer, wherein each gel layer comprises a first ionophore and each polymer layer comprises a second ionophore and a protective layer at least partially coating the polymer layer.

2. The array of claim 1, wherein the ionophore in each gel layer and each polymer layer of one gel-coated electrode is different from any other ionophore in the array of gel-coated electrodes.

3. A water quality sensor comprising:

the array of claim 1 in fluid communication with the liquid sample, and wherein the electrodes are in electrical communication with circuitry for determination of a property of at least one analyte present in the liquid sample.

4. The sensor of claim 3, wherein the property determined by the sensor is the presence of at least one analyte.

5. The sensor of claim 3, wherein the sensor determines properties of at least 10 analytes in a fluid sample.

6. The sensor of claim 3, wherein the sensor determines properties of at least 40 analytes in a fluid sample.

7. The sensor array of claim 1, wherein the first ionophore and the second ionophore are the same.

8. The sensor array of claim 1, wherein the first ionophore and second ionophore are different.

9. A sensor array made by a process comprising:

providing a substrate comprising a plurality of reference electrodes and a plurality of gel-coated electrodes, wherein each of the gel-coated electrodes are coated with a gel layer;

contacting each Of the gel layers with a different charged or polarizable ionophore;

applying an electric field to each gel layer sufficient to migrate the ionophore into the gel layer;

coating each gel layer comprising the ionophore with a polymer layer comprising the same or a different ionophore; and

coating each polymer layer with a protective layer.

10. The sensor array of claim 9, wherein each gel layer is contacted simultaneously with the different charged or polarizable ionophore.

11. The sensor array of claim 9, wherein the electric field is simultaneously applied to each gel layer.