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Nanoparticles having oligonucleotides attached thereto and uses therefor

  • US 6,730,269 B2
  • Filed: 10/12/2001
  • Issued: 05/04/2004
  • Est. Priority Date: 07/29/1996
  • Status: Expired due to Term
First Claim
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1. A method of nanofabrication comprisingproviding at least one type of linking oligonucleotide having a selected sequence, the sequence of each type of linking oligonucleotide having at least two portions;

  • providing one or more types of nanoparticles having oligonucleotides bound thereto, wherein the oligonucleotides are present on a surface of the nanoparticles at a surface density of at least 10 picomoles/cm2, at least some of the oligonucleotides on each type of nanoparticles comprise at least one type of recognition oligonucleotides, each type of recognition oligonucleotides comprises a spacer portion and a recognition portion, the spacer portion being designed so that it is bound to the nanoparticles, the recognition portion comprises a sequence complementary to at least a portion of the sequence of a specific type of linking oligonucleotide; and

    contacting the linking oligonucleotides and nanoparticles under conditions effective to allow hybridization of at least a portion of the oligonucleotides on the nanoparticles to the linking oligonucleotides so that a desired nanomaterial or nanostructure is formed.

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