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Stable protein and nucleic acid formulations using non-aqueous, anhydrous, aprotic, hydrophobic, non-polar vehicles with low reactivity

  • US 6,730,328 B2
  • Filed: 05/04/2001
  • Issued: 05/04/2004
  • Est. Priority Date: 10/16/1996
  • Status: Expired due to Term
First Claim
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1. A stable non-aqueous composition of a biologically active agent comprising:

  • a) a biologically active agent containing powder wherein the biologically active agent hydration in said powder is less than 10%; and

    b) at least one anhydrous, aprotic, hydrophobic, non-polar, low-reactivity vehicle, wherein at least one said vehicle is selected from the group consisting of perfluorodecalin, methoxyflurane, and perfluorotributylamine, and wherein said biologically active agent is selected from the group consisting of beta- and gamma-interferon.

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