Degradable polymers from derivatized ring-opened epoxides
First Claim
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1. A copolymer comprising randomly distributed units of a ring-opened functionalized epoxide and a ring-opened cyclic ester, wherein the functionalized epoxide is an epoxide having the composition E-CH2—
- CHR—
C(O)—
X-G, wherein E=R is hydrogen or alkyl, X is oxygen or nitrogen, and G comprises a derivatizable group.
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Abstract
A polymer of a ring-opened functionalized epoxide is formed by the polymerization of a functionalized epoxide monomer having the structure E-CHR-G wherein E represents an epoxide group, R is hydrogen or an alkyl group, and G is a derivatizable group such as an unsaturated functionality or ester substituent.
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Citations
36 Claims
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1. A copolymer comprising randomly distributed units of a ring-opened functionalized epoxide and a ring-opened cyclic ester, wherein the functionalized epoxide is an epoxide having the composition E-CH2—
- CHR—
C(O)—
X-G, wherein E=R is hydrogen or alkyl, X is oxygen or nitrogen, and G comprises a derivatizable group. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 31, 32, 33, 34, 35, 36)
- CHR—
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11. A method of making a copolymer comprising randomly polymerizing a functionalized epoxide and a cyclic ester, wherein the functionalized epoxide is an epoxide having the composition E-CH2—
- CHR—
C(O)—
X-G, wherein E=R is hydrogen or alkyl, X is oxygen or nitrogen, and G comprises a derivatizable group. - View Dependent Claims (12, 13, 14, 15, 16)
- CHR—
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17. The method of claim wherein the temperature is less than about 90°
- C.
- 18. A degradable polymer comprising a backbone comprised of randomly distributed ether and ester linkages, having the formula:
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25. A degradable polymer comprising a backbone of randomly distributed ether and ester linkages, wherein the ether linkages comprise a functionalized ring-opened epoxide, wherein the functionalized epoxide has the composition E-CH2—
- CHR—
C(O)—
X-G, wherein E=R is hydrogen or alkyl, X is oxygen or nitrogen, and G comprises a derivatizable group and the ester linkages are derived from one or more of the group consisting of lactide, glycolide, caprolactone, 1,4-dioxan-2-one, and cyclic carbonates. - View Dependent Claims (26, 27, 28, 29)
- CHR—
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30. A copolymer comprising randomly distributed units of a ring-opened functionalized epoxide and a ring-opened cyclic ester, wherein the ratio of an average ring-opened cyclic ester unit block length to a theoretical minimum block length, when no two ring-opened functionalized epoxide units are bound to each other, is approximately one.
Specification