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Liquid polymeric compositions for controlled release of bioactive substances

  • US 6,733,767 B2
  • Filed: 03/18/1999
  • Issued: 05/11/2004
  • Est. Priority Date: 03/19/1998
  • Status: Expired due to Term
First Claim
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1. A liquid polymeric composition for controlled release of eprinomectin consisting essentially of:

  • (a) 1 to 10% of eprinomectin;

    (b) 1 to 10% of a poly(lactide-co-glycolide) copolymer;

    wherein the weight ratio of the poly(lactide-co-glycolide) copolymer to the eprinomectin is 1;

    1 or less and the ratio of lactide;

    glycolide of the poly(lactide-co-glycolide) copolymer is from about 75;

    25 to about 65;

    35; and

    (c) at least one lipophilic solvent or a mixture of hydrophilic and lipophilic solvents, wherein the volume ratio of the hydrophilic and lipophilic solvents is from about 80;

    20 to about 5;

    95.

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