Focused ultrasound system with MRI synchronization

• US 6,735,461 B2
• Filed: 06/19/2001
• Issued: 05/11/2004
• Est. Priority Date: 06/19/2001
• Status: Expired due to Term

• Current Assignee: InSightec Ltd.
• Original Assignee: Insightec-Txsonics Limited
• Inventors: Vitek, Shuki, Freundlich, David, Ezion, Avner
• Primary Examiner(s): Ruhl, Dennis W.
• Assistant Examiner(s): QADERI, RUNA S
• Application Number:
  US09/884,206
• Publication Number:
  US 20020193681A1
• Time in Patent Office: 1,057 Days
• Field of Search: 600/411, 600/427, 600/439, 600/413, 600/428, 601/2-4
• US Class Current: 600/411
• CPC Class Codes: G01R 33/28 Details of apparatus provided for in groups G01R33/44 - G01R33/64
• CPC Class Codes: G01R 33/4804 Spatially selective measurement of temperature or pH

Abstract

Systems and methods for performing a focused ultrasound procedure monitored using magnetic resonance imaging (MRI) is provided. An MRI system uses a timing sequence for transmitting radio frequency (RF) signals and detecting magnetic resonance (MR) response signals from a patient'"'"'s body in response to the RF pulse sequences. A piezoelectric transducer is driven with drive signals such that the transducer emits acoustic energy towards a target tissue region within the patient'"'"'s body. Parameters of the drive signals are changed at times during the timing sequence that minimize interference with the MRI system detecting MR response signals, e.g., during transmission of RF signals by the MRI system.

Claims

1. A method for performing a focused ultrasound procedure being monitored using a magnetic resonance imaging (MRI) system, the MRI system using a timing sequence for transmitting radio frequency (RF) pulse sequences and detecting magnetic resonance (MR) response signals from a patient'"'"'s body in response to the RF pulse sequences, the method comprising:

driving a piezoelectric transducer with electrical drive signals such that the transducer emits acoustic energy towards a target tissue region within the patient'"'"'s body while the MRI system is detecting MR response signals;

changing parameters of the drive signals only at one or more times during the timing sequence that minimize interference with the MRI system detecting MR response signals; and

determining the timing sequence of the MRI system, wherein determining the timing sequence of the MRI system comprises

synchronizing a clock driving the MRI system with a clock driving the transducer to obtain a synchronization constant relating clock speeds of the clocks;

determining a delay between when the MRI system is initially activated and when the MRI system begins transmitting RF pulse sequences; and

determining the timing sequence of the MRI system by adjusting a predetermined cycle period of the MRI system by the delay and the synchronization constant.

2. The method of claim 1, wherein determining the timing sequence of the MRI system further comprises determining when the MRI system is transmitting RF pulse sequences, and wherein the changing parameters step comprises changing parameters of the drive signals only during times when the MRI system is transmitting RF pulse sequences.

3. The method of claim 1, wherein the changing parameters step comprises changing the parameters of the drive signals during a predetermined time interval after the MRI system transmits RF pulse sequences.

4. The method of claim 3, wherein the predetermined time interval corresponds to one or more time intervals between expected MR responses of tissue within the patient'"'"'s body.

5. The method of claim 1, wherein the changing parameters step comprises sampling drive signals driving the transducer at one or more times during the timing sequence that minimize interference with the MRI system detecting MR response signals.

6. The method of claim 1, wherein determining the timing sequence of the MRI system further comprises sampling timing signals generated by the MRI system to instruct the MRI system to transmit RF pulse sequences or to detect MR response signals.

7. The method of claim 1, wherein determining the timing sequence of the MRI system further comprises sensing when RF transmissions by the MRI system begin or end.

8. The method of claim 1, wherein the changing parameters step comprises changing at least one of amplitude, frequency and phase shift of the drive signals.

9. A system for performing a focused ultrasound procedure being monitored using a magnetic resonance imaging (MRI) system, the MRI system using a timing sequence to control transmitting radio frequency (RF) signals and detecting magnetic resonance (MR) response signals from a patient'"'"'s body in response to the RF signals, comprising:

a piezoelectric transducer;

drive circuitry coupled to the transducer, the drive circuitry configured for providing drive signals to the transducer such that the transducer emits acoustic energy towards a target tissue region within the patient'"'"'s body;

a controller coupled to the drive circuitry for activating the transducer simultaneously with the MRI system, the controller configured for controlling the drive circuitry to change parameters of the drive signals at one or more times during the timing sequence that substantially minimize interference with the MRI system detecting MR response signals generated by the patient'"'"'s body; and

means coupled to the controller for determining the timing sequence of the MRI system, comprising

means for synchronizing a clock driving the MRI system with a clock driving the transducer to obtain a synchronization constant relating clock speeds of the clocks; and

means for determining a delay between when the MRI system is initially activated and when the MRI system begins transmitting RF signals;

wherein the controller is configured for determining the timing sequence of the MRI system by adjusting a predetermined cycle period of the MRI system by the delay and by the synchronization constant.

10. The system of claim 9, wherein the controller is configured for controlling the drive circuitry to change parameters based upon the timing sequence of the MRI system.

11. The system of claim 9, wherein the controller is configured for changing parameters of the drive signals only when the MRI system transmits RF signals.

12. The system of claim 9, wherein the means for determining the timing sequence of the MRI system further comprises an interface for sampling timing signals generated by the MRI system to instruct the MRI system to transmit RF signals or to detect MR response signals.

13. The system of claim 12, wherein the interface comprises a cable for connecting to a timing sequence sampling port of the MRI system.

14. The system of claim 9, wherein the means for determining the timing sequence of the MRI system further comprises means for determining when RF signals are being transmitted by the MRI system.

15. The system of claim 14, wherein the means for determining when RF signals are being transmitted by the MRI system comprises an antenna coupled to the controller for detecting the RF signals transmitted by the MRI system.

16. The system of claim 9, wherein the controller is configured for controlling at least one of amplitude, frequency and phase shift of the respective drive signals for focusing the acoustic energy at the target tissue region.

17. The system of claim 16, wherein the controller is configured for maintaining at least one of the amplitude, frequency, and phase shift of the respective drive signals substantially constant when the MRI system is detecting MR response signals emitted by the patient'"'"'s body.

18. A method for performing a procedure being monitored using magnetic resonance imaging (MRI), the method comprising:

transmitting radio frequency (RF) pulse sequences over the patient'"'"'s body;

operating a therapeutic or diagnostic device using electrical signals to perform a therapeutic or diagnostic procedure at a target tissue region within the patient'"'"'s body;

detecting MR response signals generated by tissue within the patient'"'"'s body in response to the RF pulse sequences while the therapeutic or diagnostic device is being operated;

maintaining the electrical signals substantially constant during the detecting step, thereby substantially minimizing interference with detecting MR response signals; and

determining the timing sequence of the MRI system by

synchronizing a clock driving the MRI system with a clock controlling the electrical signals to obtain a synchronization constant relating clock speeds of the clocks;

determining a delay between when the MRI system is initially activated and when the MRI system begins transmitting RF pulse sequences; and

determining the timing sequence of the MRI system by adjusting a predetermined cycle period of the MRI system by the delay and the synchronization constant.

19. The method of claim 18, wherein the therapeutic or diagnostic device comprises a piezoelectric transducer, wherein the operating step comprises driving the transducer with electrical drive signals to direct acoustic energy towards the target tissue region, and wherein the maintaining step comprises changing parameters of the drive signals only when the RF pulse sequences are being transmitted.

20. The method of claim 19, wherein the changing parameters step comprises changing parameters of the drive signals only at one or more times during the timing sequence that substantially minimize interference with detecting the MR response signals.

21. The method of claim 20, wherein the MRI system uses a timing sequence to control when the RF sequences are transmitted and when the MR response signals are detected, and wherein the changing parameters step comprises sampling drive signals driving the transducer at one or more times during the timing sequence that minimize interference with the MRI system detecting MR response signals.

22. The method of claim 20, wherein determining the timing sequence of the MRI system further comprises sampling timing signals generated by the MRI system.

23. The method of claim 20, wherein determining the timing sequence of the MRI system further comprises sensing when the transmitting RF pulse sequences step begins or ends.

24. The method of claim 19, wherein the changing parameters step comprises changing at least one of amplitude, frequency and phase shift of the drive signals.

25. The method of claim 18, wherein the step of transmitting RF pulse sequences is synchronized with the operating step to minimize interference of the MRI system with operation of the therapeutic or diagnostic device.