Method and system for selective or isolated integrate cerebral perfusion and cooling

• US 6,736,790 B2
• Filed: 07/11/2001
• Issued: 05/18/2004
• Est. Priority Date: 02/25/1998
• Status: Expired due to Fees

• Current Assignee: Zoll Circulation Incorporated (Asahi Kasei Corporation)
• Original Assignee: Barbut Denise and Patterson Russel
• Inventors: Barbut, Denise R., Patterson, Russel H.
• Primary Examiner(s): BIANCO, PATRICIA
• Application Number:
  US09/904,016
• Publication Number:
  US 20010038807A1
• Time in Patent Office: 1,042 Days
• Field of Search: 422/44, 422/45, 422/61, 604/4.01, 604/6.01, 604/6.13, 604/6.14, 604/8, 604/19, 604/27, 604/28, 604/500, 604/506-509, 604/113, 604/164.11, 604/96.01, 604/98.01, 604/101.04, 604/102-1-1, 604/104, 604/907, 604/912, 604/915, 604/919, 604/921, 435/1.1, 435/1.2, 435/2, 435/284.1, 435/283.1, 128/898, 128/DIG.13, 128/DIG.12, 128/DIG.27, 128/DIG.913, 261/DIG.28, 606/191-195, 606/198, 606/200, 607/96, 607/104-106
• US Class Current: 604/6.13
• CPC Class Codes: A61M 1/3603 in the same direction
• CPC Class Codes: A61M 1/3613 Reperfusion, e.g. of the coronary vessels, e.g. retroperfusion
• CPC Class Codes: A61M 1/3621 Extra-corporeal blood circuits single-needle circuits A61M1/30

Abstract

Patients having diminished circulation in the cerebral vasculature as a result of cardiac arrest or from other causes are treated by flowing an oxygenated medium through an arterial access site into the cerebral vasculature and collecting the medium through an access site in the venous site of the cerebral vasculature. In addition to oxygenation, the recirculating blood may also be cooled to hypothermically treat and preserve brain tissue. Isolation and cooling of cerebral vasculature in patients undergoing aortic and other procedures is achieved by internally occluding at least the right common carotid artery above the aortic arch. Blood or other oxygenated medium is perfused through the occluded common carotid artery(ies) and into the arterial cerebral vasculature. Usually, oxygen depleted blood or other medium leaving the cerebral vasculature is collected, oxygenated, and cooled in an extracorporeal circuit so that it may be returned to the patient.

Claims

1. A method for cerebral cooling, comprising the steps of:

providing a catheter having a proximal end, a distal end, and a lumen therebetween, the distal end having a first expandable occlusive member, a second expandable occlusive member, and one or more ports therebetween and communicating with the lumen;

inserting the catheter into a right subclavian artery;

positioning the first expandable occlusive member in the right brachiocephalic artery upstream of the right common carotid artery;

positioning the second expandable occlusive member in the right subclavian artery downstream of the right common carotid artery; and

flowing hypothermic medium from the catheter into at least one of the right common carotid artery or the right vertebral artery.

2. The method of claim 1, further comprising the step of stopping blood flow within the aorta.

3. The method of claim 1, further comprising the step of performing a diagnostic or interventional procedure on the aorta.

4. The method of claim 1, further comprising the step of performing an open surgical interventional procedure on the aorta.

5. The method of claim 1, further comprising the step of positioning the second expandable occlusive member in the right subclavian artery downstream of the right vertebral artery.

6. A method for cerebral cooling, comprising the steps of:

inserting a first catheter into a right common carotid artery and expanding an occlusion member disposed about the first catheter;

inserting a second catheter into a left common carotid artery and expanding an occlusion member disposed about the second catheter;

inserting a third catheter into a descending aorta and expanding an occlusion member disposed about the third catheter;

inserting a fourth catheter into an inferior vena cava and expanding an occlusion member disposed about the fourth catheter;

flowing oxygenated medium from the first catheter into the right common carotid artery;

flowing oxygenated medium from the second catheter into the left common carotid artery;

flowing oxygenated medium from the third catheter into the descending aorta; and

withdrawing medium from the inferior vena cava.

7. The method of claim 6, further comprising the step of stopping blood flow within the aorta.

8. The method of claim 6, further comprising the step of performing a diagnostic or interventional procedure on the aorta.

9. The method of claim 6, further comprising the step of performing an open surgical interventional procedure on the aorta.

10. The method of claim 6, further comprising the step of performing repair of an aortic aneurysm, repair of an aortic dissection, reconstruction of the aorta, or endarterectomy.