Delivery device for biological composites and method of preparation thereof

• US 6,736,799 B1
• Filed: 08/24/2001
• Issued: 05/18/2004
• Est. Priority Date: 10/24/2000
• Status: Expired due to Term

• Current Assignee: Orthovita Inc. (Stryker Corporation)
• Original Assignee: Vita Licencing, Inc.
• Inventors: Marx, Jeffrey G., Erbe, Erik M., Bagga, Charanpreet S.
• Primary Examiner(s): KENNEDY, SHARON E
• Application Number:
  US09/939,505
• Time in Patent Office: 998 Days
• Field of Search: 604/181, 623/23.51, 623/23.55, 623/23.56, 623/23.58, 623/23.61, 623/23.62, 523/115, 523/116, 428/404, 427/2.26, 427/2.27, 423/305, 423/311
• US Class Current: 604/181
• CPC Class Codes: A61B 17/8816 characterised by the conduit, e.g. tube, along which fluid flows into the body or by conduit connections
• CPC Class Codes: A61B 17/8825 characterised by syringe details A61B17/8822, A61B17/8827 take precedence
• CPC Class Codes: A61L 2300/00 Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
• CPC Class Codes: A61L 27/46 with phosphorus-containing inorganic fillers
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence
• CPC Class Codes: A61L 27/56 Porous materials, e.g. foams or sponges
• CPC Class Codes: A61M 25/0097 characterised by the hub connectors A61M39/10
• CPC Class Codes: A61M 5/34 Constructions for connecting the needle , e.g. to syringe nozzle or needle hub connecting catheter tubes to hubs A61M25/0014

Abstract

An apparatus for the delivery of a biological composite and a method, kit, and system for preparing a biological composite is described herein. The biological composite includes both inorganic and biological materials.

Claims

1. An apparatus for preparing a biological composite, comprising:

a) a material chamber, having a proximal end and a distal end, and comprising a calcium phosphate material having macro-, meso- and micro-porosity, the proximal end being sealingly closed by a movable plunger; and

b) the distal end of the chamber being closed by a dismountable end cap, the end cap being provided with a point for attachment of an aspiration needle.

2. The apparatus of claim 1 further comprising a closed end cap that is interchangeable with the dismountable end cap for sealing the material chamber between the plunger and the closed end cap.

3. The apparatus of claim 1 wherein the material chamber further comprises bone marrow aspirate.

4. The apparatus of claim 1 wherein said calcium phosphate material has a porosity of at least 85%.

5. The apparatus of claim 1 wherein said calcium phosphate material has a porosity of at least 88%.

6. The apparatus of claim 1 wherein said calcium phosphate material has a porosity of at least 90%.

7. The apparatus of claim 6 wherein said calcium phosphate comprises β

-tricalcium phosphate.

8. The apparatus of claim 1 wherein the point for attachment is a Luer lock connector.

9. A kit for preparation and delivery of biologically active composites comprising:

an instrument for the injection and the withdrawal of one or more biological fluids; and

a porous, biocompatible material wherein the porous, biocompatible material comprises interconnected micro-, meso- and macro-porosity.

10. A kit of claim 9 wherein the instrument for said injection and said withdrawal of said fluids is a syringe.

11. The kit of claim 9 wherein a pre-evacuated tube is the instrument for said withdrawal of said fluids.

12. The kit of claim 9 wherein the porous, biocompatible material comprises a beta-tri-calcium phosphate.

13. The kit of claim 9 wherein the porous, biocompatible material is at least 90% porous.

14. The kit of claim 9 wherein said porous, biocompatible material is in morsel form.

15. The kit of claim 9 wherein said porous, biocompatible material is in block form.

16. The kit of claim 9 further comprising a cutting instrument.

17. The kit of claim 9 further comprising a spatula.