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Polypeptide variants with altered effector function

  • US 6,737,056 B1
  • Filed: 01/14/2000
  • Issued: 05/18/2004
  • Est. Priority Date: 01/15/1999
  • Status: Expired due to Term
First Claim
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1. A variant of a parent polypeptide comprising a human IgG1 Fc region, which variant mediates antibody-dependent cell-mediated cytotoxicity (ADCC) in the presence of human effector cells more effectively, or binds an Fc gamma receptor III (Fcγ

  • RIII) with better affinity, than the parent polypeptide and comprises two or more amino acid substitutions in the Fc region.

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