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Stable shaped particles of crystalline organic compounds

  • US 6,737,081 B2
  • Filed: 02/26/2003
  • Issued: 05/18/2004
  • Est. Priority Date: 02/25/1998
  • Status: Expired due to Term
First Claim
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1. A method for effecting a solid state crystallization of an allotropic molecular organic compound in a particle of uniform size and shape comprising:

  • a. creating a formulation comprising a pharmacotherapeutic molecular allotropic organic compound in a mixed crystalline, amorphous, or both crystalline and amorphous forms;

    b. melt congealing said formulation into a plurality of particles of uniform shape;

    c. exposing said microspheres to an atmosphere saturated with vapors of a solvent for said allotropic organic compound for a time sufficient to effect a solid state crystallization of said particles; and

    d. recovering said crystallized particles, wherein said allotropic organic compound in said recovered particles is of a uniform crystalline structure, said recovered particles have the same shape as the melt congealed particles of step (b), and said particles retain said same shape on storage in aqueous media for at least about one month.

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