Compositions containing and methods of using N-acyl-1H-aminoindenes
First Claim
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1. A pharmaceutical composition comprising a compound having the structure:
- wherein n is 1 or 2, R1 is hydrogen, a linear or branched chain C1-C8 alkyl or a linear or branched chain C1-C8 alkoxy and R2 is hydrogen or a halogen and a pharmaceutically acceptable carrier selected for a particular route of administration, the administration being selected from the group consisting of oral, intravenous, intraperitoneal, intramuscular, subcutaneous, intra-articular, intra-nasal, intra-thecal, intra-dermal, transdermal and inhalation.
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Abstract
The present invention provides novel aminoindenes having the structure:
wherein n is 1 or 2, R1 is hydrogen, linear or branched chain C1-C8 alkyl or linear or branched chain C1-C8 alkoxy and R2 is hydrogen or a halogen. Such compounds may be used to treat neurodegenerative conditions such as Alzheimer'"'"'s disease, head trauma, stroke, hypoxia, anoxia, epilepsy, convulsions, seizures.
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Citations
35 Claims
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1. A pharmaceutical composition comprising a compound having the structure:
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wherein n is 1 or 2, R1 is hydrogen, a linear or branched chain C1-C8 alkyl or a linear or branched chain C1-C8 alkoxy and R2 is hydrogen or a halogen and a pharmaceutically acceptable carrier selected for a particular route of administration, the administration being selected from the group consisting of oral, intravenous, intraperitoneal, intramuscular, subcutaneous, intra-articular, intra-nasal, intra-thecal, intra-dermal, transdermal and inhalation. - View Dependent Claims (2, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 22, 32, 33)
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3. A compound having the structure:
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wherein n is 1 or 2, R1 is hydrogen, a linear or branched chain C1-C8 alkyl or a linear or branched chain C1-C8 alkoxy and R2 is hydrogen or a halogen;
provided that when n is 1 and R1 is isobutyl, R2 cannot be H, and that when n is 2, R1 and R2 both cannot be hydrogen.- View Dependent Claims (4, 5, 23, 24, 25, 34, 35)
N-formyl-3-amino-1H-indene;
N-acetyl-3-amino-6-chloro-1H-indene;
N-formyl-6-chloro-3-amino-1H-indene; and
N-methoxycarbonyl-3-amino-1H-indene.
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23. A pharmaceutical composition comprising a therapeutically effective amount of the compound of claim 3 and a pharmaceutically acceptable carrier.
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24. A pharmaceutical composition comprising a therapeutically effective amount of the compound of claim 4 and a pharmaceutically acceptable carrier.
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25. A pharmaceutical composition comprising a therapeutically effective amount of the compound of claim 5 and a pharmaceutically acceptable carrier.
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34. The compound of claim 3 having the structure:
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35. A pharmaceutical composition comprising a therapeutically effective amount of the compound of claim 34 and a pharmaceutically acceptable carrier.
- 6. The compound of 3 claim having the structure:
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17. A compound having the structure:
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wherein n is 1 or 2, R1 is hydrogen, a linear or branched chain C1-C8 alkyl or a linear or branched chain C1-C8 alkoxy and R2 is hydrogen or a halogen;
provided that when n is 1 and R1 is isobutyl, R2 cannot be H, that when n is 2, R1 and R2 both cannot be hydrogen, and that when R1 is a methyl group, R2 cannot be hydrogen.- View Dependent Claims (18, 19, 20, 21, 27, 28, 29, 30, 31)
N-formyl-3-amino-1H-indene;
N-acetyl-3-amino-6-chloro-1H-indene;
N-formyl-6-chloro-3-amino-1H-indene; and
N-methoxycarbonyl-3-amino-1H-indene.
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19. The compound of claim 17 having the structure:
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20. The compound of claim 17 having the structure:
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21. The compound of claim 17 having the structure:
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27. A pharmaceutical composition comprising a therapeutically effective amount of the compound of claim 17 and a pharmaceutically acceptable carrier.
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28. A pharmaceutical composition comprising a therapeutically effective amount of the compound of claim 18 and a pharmaceutically acceptable carrier.
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29. A pharmaceutical composition comprising a therapeutically effective amount of the compound of claim 19 and a pharmaceutically acceptable carrier.
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30. A pharmaceutical composition comprising a therapeutically effective amount of the compound of claim 20 and a pharmaceutically acceptable carrier.
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31. A pharmaceutical composition comprising a therapeutically effective amount of the compound of claim 21 and a pharmaceutically acceptable carrier.
Specification