Catheter based probe and method of using same for detecting chemical analytes

• US 6,738,651 B1
• Filed: 07/11/2002
• Issued: 05/18/2004
• Est. Priority Date: 03/09/2000
• Status: Expired due to Term

• Current Assignee: Advanced Cardiovascular Systems Incorporated
• Original Assignee: Advanced Cardiovascular Systems Incorporated
• Inventors: Jackson, Gregg A.
• Primary Examiner(s): Hindenburg, Max F.
• Assistant Examiner(s): Kremer, Matthew J
• Application Number:
  US10/194,111
• Time in Patent Office: 677 Days
• Field of Search: 600/309-312, 600/317, 600/337, 600/322-27, 600/329, 600/332, 600/339, 600/508-510, 600/585, 600/433-435
• US Class Current: 600/310
• CPC Class Codes: A61B 1/042 characterised by a proximal camera, e.g. a CCD camera
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/1459 invasive, e.g. introduced into the body by a catheter A61B5/1464 takes precedence

Abstract

A medical diagnostic apparatus including a catheter and a probe assembly coupled to the catheter and a method involving the use of a catheter and a probe assembly coupled to the catheter. The probe assembly is capable of detecting a chemical analyte. The probe assembly includes a detection probe located within the catheter. The detection probe can be fixedly attached to the catheter or slideable within the catheter.

Claims

1. A medical diagnostic apparatus comprising:

a catheter having a first end and a second end and a lumen;

a detection probe insertable in said catheter near said first end and slidable through said lumen toward said second end, said detection probe capable of detecting a chemical analyte; and

a data processing system coupled to said detection probe,

wherein the detection probe further comprises;

a main housing having a optically clear cover positioned along the length thereof;

a fiber optic bundle housed freely within the housing; and

a membrane embedded with a fluorophore and attached to an inner surface of the optically clear cover.

2. The apparatus of claim 1, wherein the detection probe may be removed from the catheter, the optically clear cover replaced, and the probe inserted into the same or a different catheter.

3. A medical diagnostic apparatus comprising:

a catheter having a first end and a second end and a lumen;

a detection probe insertable in said catheter near said first end and slidable through said lumen toward said second end, said detection probe capable of detecting a chemical analyte; and

a data processing system coupled to said detection probe,

wherein the detection probe is for use with glutamate or glutamate dehydrogenase to diagnose one of a stroke, a neurodegenerative disorder, Huntington'"'"'s Disease, or epilepsy.

4. A medical diagnostic apparatus comprising:

a catheter having a first end and a second end and a lumen;

a detection probe insertable in said catheter near said first end and slidable through said lumen toward said second end, said detection probe capable of detecting a chemical analyte; and

a data processing system coupled to said detection probe,

wherein the detection probe is to diagnose one of a cancer cell and a vascular cell adhesion molecule.

5. A medical diagnostic apparatus comprising:

a catheter having a first end and a second end and a lumen;

a detection probe insertable in said catheter near said first end and slidable through said lumen toward said second end, said detection probe capable of detecting a chemical analyte; and

a data processing system coupled to said detection probe,

wherein the detection probe includes a fluorescent nucleic acid to detect a presence at least one of white blood cells and red blood cells.