Microfluidic flow control device with floating element

• US 6,739,576 B2
• Filed: 12/20/2001
• Issued: 05/25/2004
• Est. Priority Date: 12/20/2001
• Status: Active Grant

• Current Assignee: Agilent Technologies, Inc.
• Original Assignee: Nanostream, Inc.
• Inventors: Dantsker, Eugene, Hightower, Adrian, OʼConnor, Stephen D.
• Primary Examiner(s): Hirsch, Paul J.
• Application Number:
  US10/026,380
• Publication Number:
  US 20030116738A1
• Time in Patent Office: 887 Days
• Field of Search: 251/30-1-, 251/129-1-1, 137/827
• US Class Current: 251/129.14
• CPC Class Codes: F15C 5/00 Manufacture of fluid circuit elements; Manufacture of assemblages of such elements integrated circuits
• CPC Class Codes: F16K 2099/0076 using electrical discharge machining [EDM], milling or drilling
• CPC Class Codes: F16K 2099/008 Multi-layer fabrications
• CPC Class Codes: F16K 99/0001 Microvalves microdevices B81B1/00; manufacture or treatment of devices or systems in or on a substrate B81C1/00; microfluidic structures B01L3/5027; micropumps F04B19/006
• CPC Class Codes: F16K 99/0011 Gate valves or sliding valves
• CPC Class Codes: F16K 99/0023 with ball-shaped valve members
• CPC Class Codes: F16K 99/0046 using magnets
• CPC Class Codes: F16K 99/0057 the fluid being the circulating fluid itself, e.g. check valves
• CPC Class Codes: H01H 2029/008 using micromechanics, e.g. micromechanical liquid contact switches or [LIMMS]
• CPC Class Codes: Y10T 137/2191 By non-fluid energy field affecting input [e.g., transducer]

Abstract

A microfluidic flow control device includes a fluidic chamber, a first and a second microfluidic channel, at least one sealing surface between the first and the second channels, and a floating element disposed within the chamber. The floating element is capable of intermittently engaging the sealing surface, and movement of the floating element affects fluid flow between the first channel and the second channel. The floating element may be moved by fluid pressure, gravity, or an applied force such as a magnetic field. Multiple flow control regions may be integrated into a flow control system.

Claims

1. A microfluidic flow control device comprising:

a fluidic chamber having an associated first microfluidic channel, an associated second microfluidic channel, and at least one sealing surface disposed between the first channel and the second channel; and

a floating element disposed within the chamber, the floating element capable of intermittently engaging the at least one sealing surface;

wherein movement of the floating element affects fluid flow between the first microfluidic channel and the second microfluidic channel.

2. The microfluidic flow control device of claim 1 wherein the device is fabricated from multiple layers, the first microfluidic channel being defined in a first device layer and the second microfluidic channel being defined in a second device layer.

3. The microfluidic flow control device of claim 2 wherein the first device layer and the second device layer are stencil layers, the first channel being defined through the entire thickness of the first device layer and the second channel being defined through the entire thickness of the second device layer.

4. The microfluidic flow control device of claim 2, further comprising a third device layer disposed between the first device layer and the second device layer, wherein the third device layer defines at least a portion of the sealing surface.

5. The microfluidic flow control device of claim 1 wherein the at least one sealing surface defines an aperture that is smaller than at least one dimension of the floating element.

6. The microfluidic flow control device of claim 1 wherein the floating element is substantially non-porous.

7. The microfluidic flow control device of claim 1 wherein the floating element moves in response to a pressure differential within the device.

8. The microfluidic flow control device of claim 1 wherein the floating element moves in response to an applied external force.

9. The microfluidic flow control device of claim 8 wherein the external force is a magnetic field.

10. The microfluidic flow control device of claim 1 wherein the floating element is substantially spherical in shape.

11. The microfluidic flow control device of claim 1 wherein the floating element is fabricated with a magnetic or magnetizable material.

12. The microfluidic flow control device of claim 1, further comprising a third microfluidic channel associated with the fluidic chamber, wherein movement of the floating element selectively diverts fluid flow from the first channel to either the second channel or the third channel.

13. The microfluidic flow control device of claim 2 wherein any of the first channel or the second channel are surface micromachined.

14. The microfluidic flow control device of claim 1 wherein fluid flow is permitted in one direction through the flow control device, but is substantially blocked in the opposite direction.

15. The microfluidic flow control device of claim 1 wherein fluid flow through the device is allowed above a first threshold fluid pressure but disallowed above a second threshold fluid pressure.

16. A microfluidic flow control system comprising a plurality of interconnected microfluidic flow control devices according to claim 15.

17. A microfluidic flow control system comprising:

a microfluidic flow control device according to claim 9;

at least one magnetic actuator to generate a magnetic field; and

a controller coupled to the at least one magnetic actuator.

18. The microfluidic flow control system of claim 17, further comprising at least one field concentrating element.

19. The flow control system of claim 17 wherein the controller is programmable.