Systems and methods for assessing vascular effects of a treatment
First Claim
1. A method of assaying the efficacy of a treatment, the method of assaying comprising the steps of:
- collecting physiological information regarding cerebrovascular health status of a number of individuals serving as patients in a clinical trial before application of a treatment;
grouping the patients into at least two groups of patients such that patients with a similar cerebrovascular health status are grouped together;
applying a treatment to the at least two groups of patients;
monitoring outcomes of the treatment for each of the at least two groups of patients;
collecting physiological information regarding cerebrovascular health status of the number of individuals serving as patients in the clinical trial after application of the treatment;
correlating the physiological information regarding cerebrovascular health status of the number of individuals serving as patients in the clinical trial collected before application of the treatment;
correlating said physiological information regarding cerebrovascular health status of the number of individuals serving as patients in the clinical trial collected after application of the treatment; and
determining the efficacy of the treatment based on the outcomes of the treatment for each of the at least two groups of patients based at least on a comparison of the correlated said physiological information regarding cerebrovascular health status of the number of individuals serving as patients in a clinical trial collected before application of the treatment with the correlated said physiological information regarding cerebrovascular health status of the number of individuals serving as patients in a clinical trial collected after application of the treatment.
1 Assignment
0 Petitions
Accused Products
Abstract
The present invention relates generally to systems and methods for assessing blood flow in blood vessels, for assessing vascular health, for conducting clinical trials, for screening therapeutic interventions for adverse effects, and for assessing the effects of risk factors, therapies and substances, including therapeutic substances, on blood vessels, especially cerebral blood vessels, all achieved by measuring various parameters of blood flow in one or more vessels and analyzing the results in a defined matter. The relevant parameters of blood flow include mean flow velocity, systolic acceleration, and pulsatility index. By measuring and analyzing these parameters, one can ascertain the vascular health of a particular vessel, multiple vessels and an individual. Such measurements can also determine whether a substance has an effect, either deleterious or advantageous, on vascular health. In one of many embodiments, the present invention further provides an expert system for achieving the above.
-
Citations
27 Claims
-
1. A method of assaying the efficacy of a treatment, the method of assaying comprising the steps of:
-
collecting physiological information regarding cerebrovascular health status of a number of individuals serving as patients in a clinical trial before application of a treatment;
grouping the patients into at least two groups of patients such that patients with a similar cerebrovascular health status are grouped together;
applying a treatment to the at least two groups of patients;
monitoring outcomes of the treatment for each of the at least two groups of patients;
collecting physiological information regarding cerebrovascular health status of the number of individuals serving as patients in the clinical trial after application of the treatment;
correlating the physiological information regarding cerebrovascular health status of the number of individuals serving as patients in the clinical trial collected before application of the treatment;
correlating said physiological information regarding cerebrovascular health status of the number of individuals serving as patients in the clinical trial collected after application of the treatment; and
determining the efficacy of the treatment based on the outcomes of the treatment for each of the at least two groups of patients based at least on a comparison of the correlated said physiological information regarding cerebrovascular health status of the number of individuals serving as patients in a clinical trial collected before application of the treatment with the correlated said physiological information regarding cerebrovascular health status of the number of individuals serving as patients in a clinical trial collected after application of the treatment. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
-
-
23. A method of selecting subjects for a clinical trial comprising the steps of:
-
collecting physiological information regarding cerebrovascular health status of a number of individuals being considered as subjects for a clinical trial;
correlating the collected physiological information regarding cerebrovascular health status of the individuals being considered for the clinical trial; and
selecting subjects for the clinical trial based at least on the correlated physiological information regarding cerebrovascular health;
wherein subjects selected for participation in the clinical trial have no more than statistically insignificant variations in cerebrovascular health status; and
wherein the data regarding cerebrovascular health status comprises multi-vessel, multi-parameter measurements of cerebral blood flow. - View Dependent Claims (24, 25, 26, 27)
-
Specification