Motility analysis, display, and interpretation system

• US 6,740,047 B2
• Filed: 01/25/2002
• Issued: 05/25/2004
• Est. Priority Date: 01/25/2002
• Status: Expired due to Fees

• Current Assignee: Domenic A. Bellino, Harlan K. Holmes, Ray E. Clouse
• Original Assignee: Domenic A. Bellino, Harlan K. Holmes, Ray E. Clouse
• Inventors: Clouse, Ray E., Holmes, Harlan K., Bellino, Domenic A.
• Primary Examiner(s): Hindenburg, Max F.
• Assistant Examiner(s): FOREMAN, JONATHAN M
• Application Number:
  US10/054,791
• Publication Number:
  US 20030144604A1
• Time in Patent Office: 851 Days
• Field of Search: 128/920, 128/922-925, 600/300, 600/480, 600/485, 600/561, 600/585, 600/593, 600/587, 385/12
• US Class Current: 600/561
• CPC Class Codes: A61B 2562/0247 Pressure sensors
• CPC Class Codes: A61B 2562/043 in a linear array
• CPC Class Codes: A61B 5/036 by means introduced into body tracts A61B5/032 and A61B5/035 take precedence

Abstract

The system includes an array of transducers that simultaneously senses multiple intralumenal pressures, a data acquisition module that acquires and stores samples of the measured pressures, software routines for signal analysis, a software module for multi-dimensional data display presentations, and a software module to perform pattern recognition on the acquired data set to identify potential maladies that may be indicated by the analysis. The transduction elements are cylindrical segments that deform according to the circumferential pressures encountered. Distributing a quantity of these sensor segments at desired locations along a flexible support structure and providing a flexible sheath over the entire length forms the sensor array. Measuring the sensor deformation provides an electrical analog of the pressure causing the deformation. Acquiring these measurements in a suitable data acquisition and processing unit, including a display, printing, and plotting capability, completes the hardware elements. Integrated software modules complete the system.

Claims

1. A system for providing a probabilistic diagnosis of physiological dysfunction present in a tubular cavity within a living body, comprising:

a catheter for obtaining circumferential pressure measurements at discrete locations along the body of the catheter and presenting analog representations of the circumferential pressure measurements;

means for acquiring the analog representations and storing them to make them available for processing;

means communicating with the means for acquiring the analog representations for generating descriptive graphical displays to facilitate visualization of physiological phenomena; and

means communicating with the means for processing the analog representations and communicating with the means for generating descriptive graphical displays for interpreting physiological data obtained from within the tubular cavity within the living body and providing a probabilistic diagnosis based on the physiological data,

wherein the catheter comprises a plurality of measuring segments, each measuring segment being maximally responsive to encountered circumferential pressure, each measuring segment communicating with signal conditioning circuitry by means of an optical fiber, wherein light is transmitted to the measuring segment from a light source at the proximal end of the optical fiber to a mirror assembly located in the segment and positioned opposite the optical fiber at the distal end of the optical fiber, so that encountered circumferential pressure deforms the segment, causing a misalignment of the position of the mirror assembly vis-a-vis the distal end of the optical fiber, resulting in a modulation of reflected light strength.

2. The system of claim 1, wherein the light source at the proximal end of the optical fiber is coupled to a 2×

2 optical coupler, so that emitted light is split equally, half thereof being sensed by a reference detector and half thereof being directed toward the distal end of the optical fiber where it is modulated by encountered circumferential pressure and reflected back to the optical coupler where it is again split in half, one half being optically coupled to a signal detector and the output combined with the reference signal in an instrument amplifier where output is a replica of the modulated signal compensated for variations in emitted power.

3. The system of claim 1, wherein the means for acquiring the analog representations and storing them to make them available for processing provides for analog output of a plurality of signal channels to be sampled, with samples being stored in a mass storage device for subsequent availability for processing.

4. The system of claim 1, wherein the means for processing the analog representations is a central processing unit, where stored data is scaled, and is subjected to engineering unit conversion and signal processing routines.

5. The system of claim 1, wherein the means for generating descriptive graphical displays is a graphics generation program, wherein acquired data is presented in a graphical format providing a space-time-amplitude description of a studied event.

6. The system of claim 1, wherein the means for interpreting physiological data is a system program routine, which provides interpretation of data received and presents a most probable descriptor of any malady present.