Delivery of antihistamines through an inhalation route
First Claim
1. A composition for delivery of an antihistamine comprising a condensation aerosola) formed by volatilizing an antihistamine under conditions effective to produce a heated vapor of the antihistamine and condensing the heated vapor of the antihistamine to form condensation aerosol particles, b) wherein said condensation aerosol particles are characterized by less than 5% antihistamine degradation products, and c) wherein the aerosol MMAD is less than 3 microns.
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Accused Products
Abstract
The present invention relates to the delivery of antihistamines through an inhalation route. Specifically, it relates to aerosols containing antihistamines that are used in inhalation therapy. In a composition aspect of the present invention, the aerosol comprises particles comprising at least 5 percent by weight of an antihistamine. In a method aspect of the present invention, an antihistamine is delivered to a mammal through an inhalation route. The method comprises: a) heating a composition, wherein the composition comprises at least 5 percent by weight of an antihistamine, to form a vapor; and, b) allowing the vapor to cool, thereby forming a condensation aerosol comprising particles, which is inhaled by the mammal. In a kit aspect of the present invention, a kit for delivering an antihistamine through an inhalation route to a mammal is provided which comprises: a) a composition comprising at least 5 percent by weight of an antihistamine; and, b) a device that forms an antihistamine containing aerosol from the composition, for inhalation by the mammal.
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Citations
16 Claims
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1. A composition for delivery of an antihistamine comprising a condensation aerosol
a) formed by volatilizing an antihistamine under conditions effective to produce a heated vapor of the antihistamine and condensing the heated vapor of the antihistamine to form condensation aerosol particles, b) wherein said condensation aerosol particles are characterized by less than 5% antihistamine degradation products, and c) wherein the aerosol MMAD is less than 3 microns.
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7. A method of producing an antihistamine in an aerosol form comprising:
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a) volatilizing an antihistamine under conditions effective to produce a heated vapor of the antihistamine, and b) during said volatilizing, passing air through the heated vapor to produce aerosol particles of the antihistamine comprising less than 5% drug degradation products and an aerosol having an MMAD less than 3 μ
m.- View Dependent Claims (8, 9, 10, 11, 12, 13, 14, 15, 16)
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Specification