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Delivery of compounds for the treatment of migraine through an inhalation route

  • US 6,740,309 B2
  • Filed: 05/23/2002
  • Issued: 05/25/2004
  • Est. Priority Date: 05/24/2001
  • Status: Expired due to Fees
First Claim
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1. A composition for delivery of a migraine headache drug comprising a condensation aerosol,a) formed by volatilizing rizatriptan, zolmitriptan, sumatriptan, frovatriptan or naratriptan under conditions effective to produce a heated vapor of rizatriptan, zolmitriptan, sumatriptan, frovatriptan or naratriptan and condensing the heated vapor of rizatriptan, zolmitriptan, sumatriptan, frovatriptan or naratriptan to form condensation aerosol particles, and b) wherein said condensation aerosol particles are characterized by less than 5% rizatriptan, zolmitriptan, sumatriptan, frovatriptan or naratriptan degradation products, and c) wherein the aerosol MMAD is less than 3 microns.

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