Signal detection techniques for the detection of analytes
First Claim
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1. A method of determining the presence of target analytes in a sample comprising:
- a) applying said sample to an array comprising a plurality of electrodes, wherein at least one electrode comprises an assay complex comprising;
i) a capture binding ligand covalently attached to said electrode;
ii) a target analyte; and
iii) an electron transfer moiety;
b) applying an input waveform to said electrode to generate an output waveform comprising at least one harmonic component, having a harmonic number greater than or equal to two;
c) detecting said output waveform at said electrode;
d) analyzing said harmonic component with harmonic number greater than or equal to two to determine the presence of said target analytes.
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Abstract
The invention relates to the use of signal processing methods in order to acheive higher signal to noise ratios, to increase the detection limits of target analytes. These techniques include the monitoring of the output signal at higher harmonic frequencies.
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Citations
27 Claims
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1. A method of determining the presence of target analytes in a sample comprising:
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a) applying said sample to an array comprising a plurality of electrodes, wherein at least one electrode comprises an assay complex comprising;
i) a capture binding ligand covalently attached to said electrode;
ii) a target analyte; and
iii) an electron transfer moiety;
b) applying an input waveform to said electrode to generate an output waveform comprising at least one harmonic component, having a harmonic number greater than or equal to two;
c) detecting said output waveform at said electrode;
d) analyzing said harmonic component with harmonic number greater than or equal to two to determine the presence of said target analytes. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27)
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Specification