Method and apparatus for magnetic resonance imaging of arteries using a magnetic resonance contrast agent

• US 6,741,881 B2
• Filed: 08/05/2002
• Issued: 05/25/2004
• Est. Priority Date: 06/07/1993
• Status: Expired due to Fees

• Current Assignee: Martin R. Prince
• Original Assignee: Martin R. Prince
• Inventors: Prince, Martin R.
• Primary Examiner(s): Smith, Ruth S.
• Application Number:
  US10/212,527
• Publication Number:
  US 20030047083A1
• Time in Patent Office: 659 Days
• Field of Search: 600/410, 600/419, 600/420, 324/306, 324/307, 324/309
• US Class Current: 600/420
• CPC Class Codes: A61B 5/201 Assessing renal or kidney functions
• CPC Class Codes: A61B 5/411 Detecting or monitoring allergy or intolerance reactions to an allergenic agent or substance
• CPC Class Codes: A61B 5/416 the spleen
• CPC Class Codes: A61K 49/18 characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
• CPC Class Codes: A61M 5/007 for contrast media
• CPC Class Codes: A61M 5/1456 with a replaceable reservoir comprising a piston rod to be moved into the reservoir, e.g. the piston rod is part of the removable reservoir
• CPC Class Codes: A61M 5/16827 controlling delivery of multiple fluids, e.g. sequencing, mixing or via separate flow-paths infusion of multiple fluids without using a controller A61M5/1407
• CPC Class Codes: G01R 33/281 Means for the use of in vitro contrast agents G01R33/282 takes precedence; involving use of a contrast agent in MR imaging G01R33/5601; in vivo contrast agents A61K49/0002
• CPC Class Codes: G01R 33/5601 involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent
• CPC Class Codes: G01R 33/5619 by temporal sharing of data, e.g. keyhole, block regional interpolation scheme for k-Space [BRISK]
• CPC Class Codes: G01R 33/563 of moving material, e.g. flow contrast angiography
• CPC Class Codes: G01R 33/56308 Characterization of motion or flow; Dynamic imaging
• CPC Class Codes: G01R 33/5635 Angiography, e.g. contrast-enhanced angiography [CE-MRA] or time-of-flight angiography [TOF-MRA]

Abstract

The present invention is a technique and apparatus for providing preferential enhancement of an artery of interest relative to adjacent veins and background tissue by correlating the collection of a predetermined portion of data of a magnetic resonance contrast image during the arterial phase of the magnetic resonance contrast enhancement. The arterial phase of the contrast enhancement may be described as a period of a maximum, substantially elevated, or elevated contrast concentration in the artery of interest relative to adjacent veins. The present invention includes a detection system for monitoring and detecting the arrival of the contrast agent in the artery and tissues of interest. When the concentration of contrast agent in the artery of the region of interest is maximum, substantially elevated or elevated (e.g., about 20-50% greater than the response of the region of interest to a series of magnetic resonance pulses before administration of a magnetic resonance contrast agent), a predetermined portion of the magnetic resonance image data (e.g., data which is representative of the center of k-space) may be acquired. Thus, the present invention facilitates synchronization between collecting the central portion of k-space image data with the arterial phase of contrast enhancement. The center of k-space corresponds to the lowest spatial frequency data which dominates image contrast.

Claims

1. A magnetic resonance imaging system for imaging an artery of a patient using an administered magnetic resonance contrast agent, the magnetic resonance imaging system comprising:

a monitor unit to allow an operator to observe a change in the concentration of the contrast agent in a region of interest;

an operator interface to generate an image acquisition signal in response to an input from an operator wherein the operator generates the input after observing a change in the concentration of the contrast agent in the region of interest; and

magnetic resonance imaging unit to collect image data of an imaging sequence to image the artery, wherein the magnetic resonance imaging unit, in response to the image acquisition signal, collects image data which is representative of the central portion of k-space near the beginning of the imaging sequence and a portion of the periphery of k-space thereafter.

2. The magnetic resonance imaging system of claim 1 wherein the magnetic resonance imaging unit generates a series of images and wherein the monitor unit receives the images and depicts the images as a temporal pattern of the arrival of the contrast agent in the region of interest.

3. The magnetic resonance imaging system of claim 1 wherein the magnetic resonance imaging unit continuously or periodically generates images of the region of interest and wherein the monitoring unit displays the images of the region of interest.

4. The magnetic resonance imaging system of claim 1 further including a magnetic resonance injection unit to inject the contrast agent into the patient before or while the magnetic resonance imaging unit continuously or periodically generates images of the region of interest that are displayed by the monitoring unit.

5. A method of imaging an artery of a patient using magnetic resonance imaging and an administered magnetic resonance contrast agent, the method comprising:

monitoring a region of interest to observe a change in the concentration of the contrast agent in a region of interest;

collecting image data of a magnetic resonance imaging sequence wherein the image data which is representative of the central portion of k-space is collected near the beginning of the imaging sequence and while the concentration of contrast agent in the artery is substantially greater than a concentration of contrast agent in veins adjacent to the artery.

6. The method of claim 5 wherein the imaging sequence is a 3D imaging sequence.

7. The method of claim 5 wherein monitoring the region of interest includes continuously or periodically monitoring the region of interest to detect the arrival of the contrast agent in the region of interest.

8. The method of claim 5 further including administering the magnetic resonance contrast agent to the patient as a bolus type injection.

9. The method of claim 8 wherein a substantial portion of the peripheral portion of k-space is collected after collecting the image data which is representative of the central portion of k-space.

10. The method of claim 8 further including instructing the patient to hold his breath before collecting image data which is representative of the central portion of k-space.

11. The method of claim 8 wherein monitoring the region of interest includes periodically measuring the response of the region of interest to magnetic resonance pulses.

12. The method of claim 8 wherein monitoring the region of interest includes visually displaying the region of interest to detect the onset of arterial phase of contrast enhancement in the artery.

13. The method of claim 8 wherein monitoring the region of interest includes visually displaying the region of interest to detect the arrival of the administered magnetic resonance contrast agent in the artery.

15. The method of claim 8 wherein the imaging sequence is a 3D imaging sequence.

16. The method of claim 15 wherein collecting image data of the magnetic resonance imaging sequence includes collecting the image data after visually detecting the arrival of the administered magnetic resonance contrast agent in the region of interest.

17. The method of claim 15 wherein a substantial portion of the image data which is representative of the peripheral portion of k-space is collected after collecting the image data which is representative of the central portion of k-space.

14. A method of imaging an artery of a patient using magnetic resonance imaging and an administered magnetic resonance contrast agent, the method comprising:

monitoring a region of interest by generating a series of images depicting the temporal pattern of the arrival of the contrast agent in the region of interest;

collecting image data of a magnetic resonance imaging sequence wherein the image data which is representative of the central portion of k-space is collected near the beginning of the sequence and while the concentration of contrast agent in the artery is substantially greater than a concentration of contrast agent in veins adjacent to the artery.

18. The method of claim 14 further including instructing the patient to hold his breath before collecting image data which is representative of the central portion of k-space.

19. The method of claim 14 wherein the central portion of the k-space is collected in response to detecting the arrival of the contrast agent in the region of interest.

20. The method of claim 14 wherein a substantial portion of the image data which is representative of the peripheral portion of k-space is collected after collecting the image data which is representative of the central portion of k-space.