Flow cytometer shunt

• US 6,743,190 B2
• Filed: 07/30/2001
• Issued: 06/01/2004
• Est. Priority Date: 05/07/2001
• Status: Expired due to Fees

• Current Assignee: Biomed Solutions, LLC
• Original Assignee: Biomed Solutions, LLC
• Inventors: Gebert, Carol, Gray, Robert W., MacDonald, Stuart G., Connelly, Patrick R.
• Primary Examiner(s): Sykes, Angela D.
• Assistant Examiner(s): DEAK, LESLIE R
• Application Number:
  US09/918,078
• Publication Number:
  US 20020182738A1
• Time in Patent Office: 1,037 Days
• Field of Search: 604/4.01, 604/5.01, 604/6.08, 604/6.09, 604/265, 604/6.1, 604/6.15, 210/668, 210/669, 422/82.09, 422/44, 600/309, 600/310, 600/342, 600/407, 600/473, 600/476, 356/335-338, 435/4, 435/283.1, 424/489, 436/518, 436/63
• US Class Current: 604/4.01
• CPC Class Codes: A61B 5/0071 by measuring fluorescence emission
• CPC Class Codes: A61B 5/0084 for introduction into the body, e.g. by catheters A61B5/1459 takes precedence
• CPC Class Codes: A61B 5/076 Permanent implantations telemetry using implanted circuitry A61B5/0031; implanted stimulators for therapy A61N1/3605, A61N1/362, A61N1/372
• CPC Class Codes: A61B 5/145 Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissuemeasuring of blood pressure or blood flow A61B5/02; non-radiation detecting or locating of foreign bodies in blood A61B5/06
• CPC Class Codes: A61B 5/15003 for venous or arterial blood
• CPC Class Codes: A61B 5/155 Devices specially adapted for continuous or multiple sampling, e.g. at predetermined intervals devices loaded with multiple lancets simultaneously A61B5/15146
• CPC Class Codes: A61F 2/82 Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents stent-grafts for tubular structures of the body other than blood vessels A61F2/04; stent-grafts for blood vessels A61F2/07; instruments specially adapted for placement or removal of stents or stent-grafts A61F2/95; for closing wounds, or holding wounds closed A61B17/04 - A61B17/115; dilators A61M29/00
• CPC Class Codes: A61M 1/3621 Extra-corporeal blood circuits single-needle circuits A61M1/30
• CPC Class Codes: A61M 1/3679 by absorption A61M1/3675 takes precedence
• CPC Class Codes: A61M 1/3687 Chemical treatment A61M1/3675 takes precedence
• CPC Class Codes: A61M 1/38 Removing constituents from donor blood and storing or returning remainder to body , e.g. for transfusion
• CPC Class Codes: G01N 15/1456 without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
• CPC Class Codes: G01N 15/149 specially adapted for sorting particles, e.g. by their size or optical properties
• CPC Class Codes: G01N 2015/1006 for cytology

Abstract

A flow cytometer containg a device for sampling cellular material within a body. The flow cytometer is adapted to mark cells within bodily fluid with a marker to produce marked cells, to analyze the marked cells, to sort the cells within the bodily fluid to produce sorted cells, to maintain the sorted cells cells in a viable state, and to remove the marker from the marked cells. Two marker removal devices are used in the flow cytomter.

Claims

1. An implantable flow cytometer comprising means for sampling cellular material within a body comprised of bodily fluid, means for marking cells within said bodily fluid with a marker to produced marked cells, an analyzer for analyzing said marked cell, a first marker stripper for removing said marker from said marked cell, a second marker stripper for removing said marker from said marked cells, a cell sorter for sorting said cells within said bodily fluid to produce sorted cells, and a reservoir for maintaining said sorted cells in a viable state.

2. The flow cytometer as recited in claim 1, wherein bodily fluid is blood.

3. The flow cytometer as recited in claim 2, wherein said flow cytometer comprises a first control valve operatively connected to said first marker stripper ,and a second marker stripper.

4. The flow cytometer as recited in claim 3, wherein said first valve is connected to a controller.

5. The flow cytometer as recited in claim 1, wherein said first marker stripper is a first dye separator.

6. The flow cytometer as recited in claim 5, wherein said second marker stripper is a second dye separator.

7. The flow cytometer as recited in claim 6, further comprising a tester for testing the purity of said blood.

8. The flow cytometer as recited in claim 7, comprising means for feeding blood from said tester to said first dye separator.

9. The flow cytometer as recited in claim 8, comprising means for feeding blood from said tester to said second dye separator.

10. The flow cytometer as recited in claim 9, comprising means for feeding blood from said tester to said body.