Interface for iontophoresis

• US 6,743,432 B1
• Filed: 06/06/1996
• Issued: 06/01/2004
• Est. Priority Date: 06/14/1995
• Status: Expired due to Fees

• Current Assignee: Hisamitsu Pharmaceutical Company Incorporated
• Original Assignee: Hisamitsu Pharmaceutical Company Incorporated
• Inventors: Higo, Naruhito, Matsumoto, Yukihiro, Yanai, Shigeo, Iga, Katsumi
• Primary Examiner(s): Webman, Edward J.
• Application Number:
  US08/659,370
• Time in Patent Office: 2,917 Days
• Field of Search: 424/486, 424/400, 424/449, 428/305.5, 428/421, 604/20
• US Class Current: 424/400
• CPC Class Codes: A61N 1/0444 Membrane
• CPC Class Codes: A61N 1/0448 Drug reservoir
• CPC Class Codes: Y10T 428/249954 With chemically effective material or specified gas other than air, N, or carbon dioxide in void-containing component
• CPC Class Codes: Y10T 428/3154 Of fluorinated addition polymer from unsaturated monomers

Abstract

A hydrophilic membrane having a low adsorptivity for a protein is disposed, as an interface, on a side to be contacted with a skin, and a drug such as a physiologically active peptide is transdermally delivered by iontophoresis. The membrane has an adsorptivity for a protein of not greater than 10 μg/cm². The thickness of the membrane is about 10 to 200 μm, and the porosity of the membrane is about 60 to 90%. Such membrane includes a hydrophilized fluororesin membrane, a hydrophilized polysulfone membrane and a hydrophilized cellulose derivative membrane.

Claims

1. An interface for iontophoresis which comprises a membrane having a low adsorptivity for a protein, wherein the membrane is (1) a hydrophilized fluororesin membrane of a homo- or co-polymer composed of a fluorine-containing monomer having a hydrophilic group as a constitutive unit, (2) a hydrophilized polysulfone membrane incorporating a wetting agent or (3) a hydrophilized cellulose derivative membrane.

2. The interface as claimed in claim 1, wherein the fluorine-containing monomer is a fluoroethylene having a hydrophilic group or a vinylidene fluoride having a hydrophilic group.

3. The interface as claimed in claim 1, wherein the hydrophilized fluororesin is at least one member selected from the group consisting of a polyfluoroethylene, a fluoroethylene-tetrafluoroethylene copolymer, a fluoroethylene-hexafluoropropylene copolymer, an ethylene-fluoroethylene copolymer, an ethylene-chlorotrifluoroethylene copolymer, a poly(vinylidene flouride, a fluoroethylene-vinylidene fluoride copolymer and an ethylene-vinylidene fluoride copolymer, and is introduced with a hydrophilic group.

4. The interface as claimed in claim 1, wherein the hydrophilic group is at least one member selected from the group consisting of a hydroxyl group, a carboxyl group, an amino group, a mono- or di-C_1-4 alkylamino group, an ether group, a hydroxy-C_1-4 alkyl group, a carboxy-C_1-4 alkyl group, an amino-C_1-4 alkyl group and a mono- or di-C_1-4 alkylamino-C_1-4 alkyl group.

5. The interface as claimed in claim 1, wherein the hydrophilic group is a hydroxy-C_2-3 alkyl group or a (poly)oxyalkylene group.

6. The interface as claimed in claim 1, wherein the membrane has an adsorptivity for a protein of 0 to 10 μ

g per 1 cm².

7. The interface as claimed in claim 1, wherein the membrane has a thickness of 1 to 300 μ

m.

8. The interface as claimed in claim 1, wherein the membrane is a porous membrane having pores with a mean pore size of 0.01 to 20 μ

m.

9. The interface as claimed in claim 1, wherein the membrane has a porosity of 60 to 90%.

10. The interface as claimed in claim 1, wherein the ionic surfactant is a cationic surfactant.

11. The interface as claimed in claim 1, wherein the ionic surfactant is a quaternary ammonium salt.

12. The interface as claimed in claim 1, wherein the ionic surfactant is an alkylbenzyldimethylammonium halide shown by the following formula

13. The interface as claimed in claim 1, wherein the membrane has a thickness of 10 to 200 μ

m and an area of 1 to 10 cm².

14. The interface as claimed in claim 1, wherein the hydrophilized fluororesin membrane is a poly(vinylidene flouride) and wherein the hydrophilic group is a hydroxy-C_2-3 alkyl group.