Death domain containing receptor 5
First Claim
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1. An isolated TRAIL receptor DNA, wherein said DNA comprises the nucleotide sequence presented in SEQ ID NO:
- 1.
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Abstract
The present invention relates to novel Death Domain Containing Receptor-5 (DR5) proteins which are members of the tumor necrosis factor (TNF) receptor family, and have now been shown to bind TRAIL. In particular, isolated nucleic acid molecules are provided encoding the human DR5 proteins. DR5 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying antagonists and antagonists of DR5 activity.
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48 Claims
- 1. An isolated TRAIL receptor DNA, wherein said DNA comprises the nucleotide sequence presented in SEQ ID NO:
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14. An isolated TRAIL receptor DNA, wherein said DNA encodes a polypeptide comprising amino acids −
- 51 to 360 of SEQ ID NO;
2. - View Dependent Claims (15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25)
- 51 to 360 of SEQ ID NO;
- 26. An isolated TRAIL receptor DNA that encodes a polypeptide capable of binding TRAIL, wherein said polypeptide comprises amino acids 1 to 360 of SEQ ID NO:
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38. An isolated TRAIL receptor DNA, wherein said DNA encodes a polypeptide comprising amino acids −
- 51 to 133 of SEQ ID NO;
2. - View Dependent Claims (39, 40, 41, 42, 43, 44, 45, 46, 47, 48)
- 51 to 133 of SEQ ID NO;
Specification