Magnetizable bead detector

• US 6,743,639 B1
• Filed: 10/13/2000
• Issued: 06/01/2004
• Est. Priority Date: 10/13/2000
• Status: Active Grant

• Current Assignee: NVE Corporation
• Original Assignee: NVE Corporation
• Inventors: Tondra, Mark C., Anderson, John M.
• Primary Examiner(s): Chin, Christopher L.
• Assistant Examiner(s): Do, Pensee T.
• Application Number:
  US09/687,791
• Time in Patent Office: 1,327 Days
• Field of Search: 324/252, 360/324, 360/313, 360/314, 360/316, 338/32, 338/32.H, 365/158, 436/518, 436/525, 436/526, 436/149, 436/150, 436/151, 436/806, 422/50, 422/68.1, 435/4, 435/7.7, 435/7, 435/7.9 D, 435/7-3-
• US Class Current: 436/518
• CPC Class Codes: G01N 27/745 for detecting magnetic beads used in biochemical assays concerning the assays G01N33/54326; sensors therefor G01R33/1269; automatic analysers therefor G01N35/0098
• CPC Class Codes: G01R 33/09 Magnetoresistive devices

Abstract

A ferromagnetic thin-film based magnetic field detection system used for detecting the presence of selected molecular species. A magnetic field sensor supported on a substrate has a binding molecule layer positioned on a side thereof capable of selectively binding to the selected molecular species. The magnetic field sensor can be substantially covered by an electrical insulating layer having a recess therein adjacent to the sensor in which the binding molecule layer is provided. An electrical interconnection conductor can be supported on the substrate at least in part between the sensor and the substrate, and is electrically connected to the sensor. The magnetic field sensor can be provided in a bridge circuit, and can be formed by a number of interconnected individual sensors.

Claims

1. A ferromagnetic thin-film based magnetic field detection system, said system comprising:

a substrate;

a magnetic field sensor supported on said substrate having a pair of terminating regions between which occurs an electrical resistance having magnitudes dependent on magnetic fields occurring about said magnetic field sensor;

an electrical interconnection conductor supported on said substrate at least in part between said magnetic field sensor and said substrate, and electrically connected to one of said terminating regions of said magnetic field sensor; and

a binding molecule layer positioned on that side of said magnetic field sensor opposite said substrate, said binding molecule layer selectively binds to selected molecular species.

2. The system of claim 1 wherein said magnetic field sensor is substantially covered by an electrical insulating layer having a recess therein adjacent to said magnetic field sensor in which said binding molecule layer is provided.

3. A ferromagnetic thin-film based magnetic field detection system, said system comprising:

a substrate;

a magnetic field sensor supported on said substrate;

an electrical insulating layer substantially covering said magnetic field sensor having a recess therein adjacent to said magnetic field sensor; and

a binding molecule layer positioned in said recess, said binding molecule layer selectively binds to selected molecular species.

4. The system of claim 3 wherein said magnetic field sensor is formed of at least a pair of electronically interconnected individual magnetic sensors all located across a portion of said electrical insulating layer from said binding molecule layer.

5. The system of claim 3 wherein said recess extends into said substrate.