Estrogen mimetics lacking reproductive tract effects
First Claim
1. A method for treating extra-reproductive tract tissues that are responsive to treatment with estrogen comprising administering to a patient an effective amount of a nonuterotrophic compound having the structure wherein R1 is —
- O(CH2)mR3 or —
(CH2)nR3;
R3 is an anionic substituent;
m is 1, 2, 3 or 4;
n is 0, 1, 2, 3 or 4; and
R2 is para —
OH.
1 Assignment
0 Petitions
Accused Products
Abstract
A method for treating symptoms, diseases and conditions in extra-reproductive tract tissues that are responsive to treatment with estrogen, using triarylethanes of formula (I)
wherein R1 is —O(CH2)mR3 or —(CH2)nR3; wherein R3 is an anionic substituent; m is an integer from 1 to 4; and n is an integer from 0 to 4; and wherein R2 is either H or —OH. Each of R1 and R2 can be either meta or para to its respective phenyl ethyl linkage. Compounds having the formula (I) wherein R1 is —O(CH2)mR3 or —(CH2)nR3; R3 is an anionic substituent; m is 1, 2, 3 or 4; n is 0, 1, 2, 3 or 4; R2 is H or —OH; and wherein each of R1 and R2 is independently meta or para to its respective phenyl ethyl linkage are also provided, with the proviso that R2 is not para —OH when m is 1 and R3 is —COOH.
11 Citations
10 Claims
-
1. A method for treating extra-reproductive tract tissues that are responsive to treatment with estrogen comprising administering to a patient an effective amount of a nonuterotrophic compound having the structure
wherein R1 is — - O(CH2)mR3 or —
(CH2)nR3;
R3 is an anionic substituent;
m is 1, 2, 3 or 4;
n is 0, 1, 2, 3 or 4; and
R2 is para —
OH. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
- O(CH2)mR3 or —
-
10. A pharmaceutical composition comprising a compound having the structure
wherein R1 is — - (CH2)nR3;
R3 is an anionic substituent;
n is 0, 1, 2, 3 or 4; and
R2 is para —
OH;
or a pharmaceutically acceptable salt thereof; and
a pharmaceutically acceptable carrier.
- (CH2)nR3;
Specification