Method and system for low-dose three-dimensional imaging of a scene

• US 6,744,848 B2
• Filed: 02/12/2001
• Issued: 06/01/2004
• Est. Priority Date: 02/11/2000
• Status: Active Grant

• Current Assignee: Brandeis University
• Original Assignee: Brandeis University
• Inventors: Stanton, Martin, Phillips, Walter, Stewart, Alexander
• Primary Examiner(s): Bruce, David V.
• Assistant Examiner(s): THOMAS, COURTNEY D
• Application Number:
  US09/781,787
• Publication Number:
  US 20010038681A1
• Time in Patent Office: 1,205 Days
• Field of Search: 378/37, 378/55, 378/62, 378/64, 378/98.8, 378/98.9, 378/98.12
• US Class Current: 378/55
• CPC Class Codes: A61B 6/032 Transmission computed tomography [CT]
• CPC Class Codes: A61B 6/4085 Cone-beams
• CPC Class Codes: A61B 6/4488 Means for cooling A61B6/045 takes precedence
• CPC Class Codes: A61B 6/466 adapted to display 3D data
• CPC Class Codes: A61B 6/502 for diagnosis of breast, i.e. mammography
• CPC Class Codes: G01B 15/025 by measuring absorption
• CPC Class Codes: G01N 2223/419 computed tomograph
• CPC Class Codes: G01N 23/046 using tomography, e.g. computed tomography [CT]
• CPC Class Codes: G06T 11/006 Inverse problem, transformation from projection-space into object-space, e.g. transform methods, back-projection, algebraic methods
• CPC Class Codes: G06T 2211/436 Limited angle

Abstract

The present invention provides a system for imaging an object by irradiating it with low doses of radiation, such as x-ray, from a plurality of positions angularly distributed about the object, and analyzing the intensity of the radiation transmitted through the object. A system according to the invention can include a radiation source, a low noise detector, and an image processor. The radiation source emits radiation toward a target scene, containing an object to be imaged, from a plurality of angular positions. In one embodiment, the plurality of angular positions defines an arc about the target scene. In another embodiment, the radiation source moves in a series of steps of varying angular spacing along the arc to generate the multiple images of the scene. The detector is positioned to detect radiation transmitted through the scene and produces radiation transmission data representing the intensity of the radiation transmitted through the scene. The image processor receives the radiation transmission data from the detector and produces a three-dimensional image of the scene. In some embodiments of the invention, the resolution of the detector can be varied. In such embodiments, the system of the invention further includes a resolution controller that varies the spatial resolution of the detector in response to the angular position from which radiation is emitted toward the scene.

Claims

1. A method for imaging a scene, comprising the steps of

irradiating a scene from a plurality of angular positions,

detecting radiation transmitted through the scene at a plurality of different spatial resolutions corresponding to the plurality of angular positions;

producing two-dimensional transmission data representative of the intensity of the radiation transmitted through the scene at each of the plurality of angular positions; and

producing a three-dimensional image of the scene based on said two-dimensional transmission data.

2. The method of claim 1, wherein the step of irradiating the scene further comprises the step of irradiating the scene using x-ray radiation.

3. The method of claim 2, wherein the step of irradiating the scene further comprises the step of irradiating the scene using a total radiation dose which is less than or approximately equal to a dose of a standard screening mammogram.

4. The method of claim 3, wherein said standard dose is approximately 80 mrad per image.

5. The method of claim 1, wherein the plurality of angular positions forms an arc about the scene.

6. The method of claim 5, wherein the arc spans a plane and has an axis of rotation on a line in the plane that is perpendicular to the scene and that extends through approximately the center of the scene.

7. The method of claim 1, wherein the step of irradiating the scene further comprises the step of varying the angular spacing between the plurality of angular positions.

8. The method of claim 1, wherein the scene is a three-dimensional scene and wherein the step of producing radiation transmission data further comprises the steps of:

producing high resolution radiation transmission data for two dimensions of the scene; and

producing low resolution radiation transmission data for a third dimension of the scene.

9. A method of imaging an object, comprising the steps of:

irradiating the object from a plurality of non-uniformly distributed angular positions;

detecting radiation transmitted through the object for each of said angular positions to create two-dimensional transmission data; and

constructing a three-dimensional image of the object by analyzing said radiation transmission data;

wherein the step of irradiating includes irradiating the object with a first radiation dose at one angular position of the source and irradiating the object with a second radiation dose at another angular position, said second radiation dose being different from said first radiation dose.

10. A method of imaging an object, comprising the steps of:

irradiating the object from a plurality of non-uniformly distributed angular positions,

detecting radiation transmitted through the object for each of said angular positions to create two-dimensional transmission data; and

constructing a three-dimensional image of the object by analyzing said radiation transmission data;

wherein the step of irradiating the object comprises selecting a sufficiently low dose of radiation for each angular irradiation such that a total dose of radiation per three-dimensional image is approximately 80 mrad.

11. A method of imaging an object, the method comprising the steps of:

irradiating the object multiple times, each irradiation being performed at a position angularly displaced from a previous irradiation position, said annular positions being non-uniformly distributed about the object;

detecting radiation transmitted through the object at each of said angular positions to create two-dimensional radiation transmission data; and

constructing a three dimensional image of the object by analyzing said transmission data;

wherein the step of irradiating the object comprises selecting each irradiation dose to be sufficiently low such that total dose of radiation per three-dimensional image is approximately 80 mrad.

12. A method of imaging an object, comprising the steps of:

irradiating the object from a plurality of non-uniformly distributed angular positions;

detecting radiation transmitted through the object for each of said angular positions at a different spatial resolution to create a two-dimensional radiation transmission data; and

constructing a three-dimensional image of the object by analyzing said transmission data.

13. A method of imaging an object, the method comprising the steps of:

irradiating the object multiple times, each irradiation being performed at a position angularly displaced from a previous irradiation position, said angular positions being non-uniformly distributed about the object;

detecting radiation transmitted through the object at each of said angular positions at a different spatial resolution to create a two-dimensional radiation transmission data; and

constructing a three-dimensional image of the object by analyzing said radiation transmission data.