Iontophoretic drug delivery system
First Claim
1. A self-contained, wearable, pre-packaged iontophoretic drug delivery system comprising:
- (a) a removable substrate;
(b) an aqueous anode matrix removably carried on said substrate and isolated by a water impermeable release membrane;
(c) an aqueous cathode matrix removably carried on said substrate and isolated by a water impermeable release membrane;
(d) an iontophoresis device including an anode electrode and a cathode electrode and a source of electric power carried on said substrate;
(e) wherein said iontophoresis device includes shaped recesses associated with said anode and said cathode configured to receive said aqueous anode matrix and said aqueous cathode matrix, respectively, in conductive relation;
(f) at least one fold line on said removable substrate to enable the pre-packaged system to fold on itself to thereby associate said anode matrix and said cathode matrix with said anode electrode and said cathode electrode; and
(g) an amount of a therapeutic ion species to be delivered transdermally by iontophoresis located in at least one of said anode matrix, said cathode matrix and said iontophoresis device.
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Accused Products
Abstract
A reliable, self-contained iontophoretic drug delivery system is disclosed which enjoys a long stable shelf life and which is easy for the user to activate and employ. This system includes a wearable iontophoretic device that is prepackaged as a complete self-contained unit which includes the active species or drug to be administered and counter ions. The system includes a provision for isolating moisture sources from the electrodes and from the power source during storage and provides a simple, user-friendly mechanism to connect the drug to be administered and counter ion reservoirs to the electrodes and the device to the skin of a user in order to activate the device circuit. All elements of the device are contained in a single outer package.
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Citations
17 Claims
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1. A self-contained, wearable, pre-packaged iontophoretic drug delivery system comprising:
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(a) a removable substrate;
(b) an aqueous anode matrix removably carried on said substrate and isolated by a water impermeable release membrane;
(c) an aqueous cathode matrix removably carried on said substrate and isolated by a water impermeable release membrane;
(d) an iontophoresis device including an anode electrode and a cathode electrode and a source of electric power carried on said substrate;
(e) wherein said iontophoresis device includes shaped recesses associated with said anode and said cathode configured to receive said aqueous anode matrix and said aqueous cathode matrix, respectively, in conductive relation;
(f) at least one fold line on said removable substrate to enable the pre-packaged system to fold on itself to thereby associate said anode matrix and said cathode matrix with said anode electrode and said cathode electrode; and
(g) an amount of a therapeutic ion species to be delivered transdermally by iontophoresis located in at least one of said anode matrix, said cathode matrix and said iontophoresis device. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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Specification