Electrodes with multilayer membranes and methods of making the electrodes
First Claim
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1. A sensor, comprising:
- a sensing layer comprising an osmium redox polymer disposed on a substrate;
a multilayer flux-limiting membrane comprising a first layer, any subsequent layers, and a polyanionic last layer disposed over the sensing layer, the first layer disposed on and binding to the sensing layer, at least one of the first layer and any subsequent layer being polycationic and comprising pyridine, each layer disposed on and bound to the immediately preceding layer of the membrane.
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Abstract
A sensor including a sensing layer is disposed over an electrode or an optode and a layer-by-layer assembled mass transport limiting membrane disposed over the sensing layer. The membrane includes at least one layer of a polyanionic or polycationic material. The assembled layers of the membrane are typically disposed in an alternating manner. The sensor also optionally includes a biocompatible membrane.
1107 Citations
23 Claims
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1. A sensor, comprising:
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a sensing layer comprising an osmium redox polymer disposed on a substrate;
a multilayer flux-limiting membrane comprising a first layer, any subsequent layers, and a polyanionic last layer disposed over the sensing layer, the first layer disposed on and binding to the sensing layer, at least one of the first layer and any subsequent layer being polycationic and comprising pyridine, each layer disposed on and bound to the immediately preceding layer of the membrane. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 10, 11, 12, 13, 14, 15, 16, 17, 18)
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9. The sensor of clam 1, wherein the osmium redox polymer comprises a non-leachable redox compound.
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19. A method of making a sensor, the method comprising steps of:
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disposing a sensing layer on a surface; and
forming a membrane over the sensing layer by chemisorbing, in an alternating and binding manner, at least three layers alternating between polyanionic layers and polycationic layers comprising pyridine, with a last layer being a polyanionic layer. - View Dependent Claims (20)
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21. A method of making a sensor, the method comprising steps of:
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disposing a sensing layer on a substrate;
disposing and binding a first membrane layer on the sensing layer;
optionally disposing one or more subsequent membrane layers on the first membrane layer; and
disposing a polyanionic last membrane layer, wherein at least one of the first membrane layer and any optional subsequent membrane layer is polycationic and comprises pyridine. - View Dependent Claims (22, 23)
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Specification