Proteins with insulin-like activity useful in the treatment of diabetes
First Claim
Patent Images
1. A protein having insulin activity comprising an amino acid sequence of SEQ ID NO:
- 2, wherein said protein has at least one substitution selected from B4-Y and B4F.
1 Assignment
0 Petitions
Accused Products
Abstract
The invention relates to novel insulin activity (IA) proteins and nucleic acids. The Invention further relates to the use of the IA proteins in the treatment of insulin related disorders such as type 1 diabetes and type 2 diabetes.
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Citations
14 Claims
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1. A protein having insulin activity comprising an amino acid sequence of SEQ ID NO:
- 2, wherein said protein has at least one substitution selected from B4-Y and B4F.
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2. A protein having insulin activity comprising an amino acid sequence of SEQ ID NO:
- 2 wherein said protein has at least one substitution selected from the group of B5-F, B5-W, B14-F, B14-W, B14-Y, and B14-L.
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3. A protein having insulin activity comprising an amino acid sequence selected from the group of amino acid sequence shown in SEQ ID NO:
- 7, SEQ ID NO;
8, SEQ ID NO;
9, SEQ ID NO;
10, SEQ ID NO;
11, SEQ ID NO;
12, SEQ ID NO;
13, SEQ ID NO;
14, SEQ ID NO;
15, SEQ ID NO;
16, SEQ ID NO;
17, SEQ ID NO;
18, SEQ ID NO;
19, SEQ ID NO;
20, SEQ ID NO;
21, SEQ ID NO;
22, SEQ SEQ ID NO;
23. - View Dependent Claims (4, 5, 6, 7, 8, 9, 10, 11)
- 7, SEQ ID NO;
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12. A protein having insulin activity comprising an amino acid sequence of SEQ ID NO:
- 2, wherein said protein comprises an least 2 amino acid substitutions from the A-chain and at least 5 amino acid substitutions from the B-chain and said substitutions are selected from the group consisting of A1N, A10Q, A16Y, A17Y, A17L, A17W, A17Q, A19F, B1D, B2E, B2T, B2K, B2Q, B2D, B2R, B2N, B2F, B4Y, B4F, B4E, B4K, B4R, B8L, B8L, B8K, B8E, B11I, B12R, B12K, B14F, B14W, B14Y, B14I, B14B, B14R, B14K, B14L, B25N, B26F, B27D, B28N, and B28F.
- View Dependent Claims (13)
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14. A recombinant nucleic acid encoding the non-naturally occurring IA protein selected from the group consisting of:
- SEQ ID NO;
7, SEQ ID NO;
8, SEQ ID NO;
9, SEQ ID NO;
10, SEQ ID NO;
11, SEQ ID NO;
12, SEQ ID NO;
13, SEQ ID NO;
14, SEQ ID NO;
15, SEQ ID NO;
16, SEQ ID NO;
17, SEQ ID NO;
18, SEQ ID NO;
19, SEQ ID NO;
20, SEQ ID NO;
21, SEQ ID NO;
22, and SEQ ID NO;
23.
- SEQ ID NO;
Specification