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Atrial interval based heart rate variability diagnostic for cardiac rhythm management system

  • US 6,748,272 B2
  • Filed: 05/18/2001
  • Issued: 06/08/2004
  • Est. Priority Date: 03/08/2001
  • Status: Expired due to Term
First Claim
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1. A method including:

  • detecting, over a time period, intrinsic atrial heart contractions;

    sampling P-P intervals between the intrinsic atrial heart contractions to obtain a time-domain P-P interval signal;

    filtering the P-P interval signal to obtain a time-domain second signal including frequency components substantially in a first frequency band, wherein the second signal is influenced by both sympathetic and parasympathetic components of the autonomic nervous system;

    filtering the P-P interval signal to obtain a time-domain third signal including frequency components substantially in a second frequency band, wherein the third signal is influenced by the parasympathetic component of the autonomic nervous system and not substantially influenced by the sympathetic component of the autonomic nervous system;

    determining a time domain variance of each of the second and third signals; and

    providing an indication associated with a balance between sympathetic and parasympathetic components of the autonomic nervous system based on the variances of the time-domain second and third signals.

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