Method for blood infrared spectroscopy diagnosing of inner organs pathology
First Claim
1. A method for rapid diagnosis of an organ specific disease state of a subject, using an infrared spectroscopy of a blood sample of said subject, said method comprising the steps of:
- irradiating said blood sample with an infrared light, obtaining an infrared absorbance spectra of said blood sample in a frequency ranging from about 400 cm−
1 to about 2000 cm−
1 and further from about 3000 cm−
1 to about 3100 cm−
1, comparing said infrared absorbance spectra with a normal infrared absorbance spectra correspondingly obtained from blood of known healthy subjects, identifying deviations of said infrared absorbance spectra from said normal infrared absorbance spectra in predetermined organ specific regions of said frequency range, and providing a diagnosis for an organ specific disease state based on the presence of said deviations.
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Abstract
A rapid diagnosis method for organ specific disease state is based on obtaining an infrared absorbance spectra of a patient'"'"'s blood at a frequency range from about 400 cm−1 to about 2000 cm−1 and further from about 3000 cm−1 to about 3100 cm−1. Comparing it with the predetermined normal infrared absorbance spectra of known healthy subjects for the presence or absence of predetermined features such as increase or decrease of infrared absorbance, peaks at particular frequencies allows for accurate diagnosis of a disease of an organ, including most major organs such as a heart, lungs, stomach, liver, kidneys, brain, etc.
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Citations
85 Claims
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1. A method for rapid diagnosis of an organ specific disease state of a subject, using an infrared spectroscopy of a blood sample of said subject, said method comprising the steps of:
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irradiating said blood sample with an infrared light, obtaining an infrared absorbance spectra of said blood sample in a frequency ranging from about 400 cm−
1 to about 2000 cm−
1 and further from about 3000 cm−
1 to about 3100 cm−
1,comparing said infrared absorbance spectra with a normal infrared absorbance spectra correspondingly obtained from blood of known healthy subjects, identifying deviations of said infrared absorbance spectra from said normal infrared absorbance spectra in predetermined organ specific regions of said frequency range, and providing a diagnosis for an organ specific disease state based on the presence of said deviations. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85)
three large peaks at the frequencies of about 1590 cm−
1-1610 cm−
1, 1640 cm−
1-1650 cm−
1and 1660 cm−
1-1680 cm−
1 on the top of a big peak at a frequency of about 1650 cm−
1 (instead a normally presented peak at a frequency of about 1650 cm−
1),total lack of a peak at a frequency of about 1550 cm−
1 (instead a normally presented peak at a frequency of about 1550 cm−
1),the lack of peaks at the frequencies of about 1460 cm−
1 and 1410 cm−
1 with transformation into a “
saw”
-shaped line with a multitude of smaller peaks in a frequency range from about 1380 cm−
1 to about 1460 cm−
1 (instead the normally presented peaks at the frequencies of about 1460 cm−
1 and 1410 cm−
1),whereby such presence indicating a state of severe hypoxic ischemic perinatal enceplopathy with intracranial intraventricular hemorrhage.
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76. The method as in claim 68, further including a step of examining said region of said infrared absorbance spectra for the presence of:
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two small peaks of the same elevation at the frequencies of about 1630 cm−
1 and 1665 cm−
1 on the top of a big peak at a frequency of about 1650 cm−
1 (instead a normally presented peak at a frequency of about 1650 cm−
1),a “
terrace”
-like descendent line in a frequency range from about 1500 cm−
1 to about 1600 cm−
1 (instead a normally presented peak at a frequency of about 1550 cm−
1),a short and wide “
trapezium”
-like peak with a cut top at a frequency range from about 1450 cm−
1 to about 1480 cm−
1 (instead a normally presented peak at a frequency of about 1460 cm−
1),a short and wide “
trapezium”
-shaped peak with a cut top at a frequency range from about 1390 cm−
1 to about 1410 cm−
1 (instead a normally presented peak at a frequency of about 1410 cm−
1),whereby such presence indicating a state of hypoxic ischemic perinatal encephalopathy of a moderate degree.
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77. The method as in claim 68, further including a step of examining said region of said infrared absorbance spectra for the presence of:
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two small peaks with different elevation;
a higher peak at a frequency of about 1670 cm−
1 and a lower peak at a frequency of about 1645 cm−
1 on the top of a big peak at a frequency of about 1650 cm−
1 (instead a normally presented peak at a frequency of about 1650 cm−
1),a “
saw”
-like horizontal line with a multitude of smaller peaks in a frequency range from about 1540 cm−
1 to about 1610 cm−
1 (instead a normally presented peak at a frequency of about 1550 cm−
1),a widened and flattened peak at a frequency of about 1460 cm−
1, which is normally higher and narrower,a slightly widened and flattened peak at a frequency of about 1400 cm−
1,whereby such presence indicating a state of hypoxic ischemic perinatal encephalopathy of a mild degree.
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78. The method as in claim 68, further including a step of examining said region of said infrared absorbance spectra for the presence of:
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a small elongated “
rectangular”
-shaped peak at a frequency range from about 1660 cm−
1 to about 1670 cm−
1 and a small flat “
tent”
-like peak at a frequency of about 1650 cm−
1 on the top of a big peak at a frequency of about 1650 cm−
1 (instead a normally presented peak at a frequency of about 1650 cm−
1),three small peaks at the same elevation at the frequencies of about 1510 cm−
1, 1530 cm−
1 and 1550 cm−
1 on the top of a big peak at a frequency of about 1550 cm−
1 (instead a normally presented peak at a frequency of about 1650 cm−
1),an elongated peak at a frequency of about 1450 cm−
1 which splits on the top into two smaller peaks at frequencies of about 1440 cm−
1 and 1455 cm−
1,an elongated peak at a frequency range from about 1390 cm−
1 to about 1410 cm−
1 with a little sharp peak on the top at a frequency of about 1390 cm−
1,whereby such presence indicating a state of brain injury of a minor degree.
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79. The method as in claim 68, further including a step of examining said region of said infrared absorbance spectra for the presence of:
-
two large widened and flattened peaks at the frequencies of about 1620 cm−
1 and 1640 cm−
1 on the top of a big peak at a frequency of about 1650 cm−
1 (instead a normally presented peak at a frequency of about 1650 cm−
1),a “
wave”
-like horizontal line in a frequency range from about 1510 cm−
1 to about 1600 cm−
1 (instead a normally presented peak at a frequency of about 1550 cm−
1),a peak at a frequency of about 1430 cm−
1 (instead a normally presented peak at a frequency of about 1460 cm−
1),a flattened rounded peak at a frequency of about 1390 cm−
1 (instead a normally presented peak at a frequency of about 1410 cm−
1),reduction of the ratio of the peak at about 1390 cm−
1 to the peak at about 1430 cm−
1 to about 0.4 (in norm-1.0),whereby such presence indicating a state of postnatal head injury of a moderate degree.
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80. The method as in claim 68, further including a step of examining said region of said infrared absorbance spectra for the presence of:
-
two bulky peaks (on the top of a big peak at a frequency of about 1650 cm−
1) at the frequencies of about 1640 cm−
1 and 1660 cm−
1-1680 cm−
1,three pronounced peaks of the different elevation (on the top of a big peak at a frequency of about 1550 cm−
1) at the frequencies of about 1510 cm−
1, 1530 cm−
1-1540 cm−
1 and 1560 cm−
1,two peaks at the frequencies of about 1450 cm−
1 and 1470 cm−
1 (instead a normally presented peak at a frequency of about 1460 cm−
1),a dramatically enlarged peak at a frequency of about 1390 cm−
1 (instead a normally presented a peak at a frequency of about 1410 cm−
1),whereby such presence indicating a state of severe acute bacterial meningitis.
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81. The method as in claim 68, further including a step of examining said region of said infrared absorbance spectra for the presence of:
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a dramatically enlarged and much sharper than the more rounded in norm peaks at the frequencies of about 1650 cm−
1, 1550 cm−
1, 1450 cm−
1 and 1390 cm−
1,increase of the ratio of the peak at about 1390 cm−
1 to the peak at about 1450 cm−
1 up to about 1.2-1.3 (in norm-1.0),whereby such presence indicating a state of cerebrosclerosis.
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82. The method as in claim 68, further including a step of examining said region of said infrared absorbance spectra for the presence of:
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a split without divergence on the top of a peak at a frequency of about 1650 cm−
1 with a transformation into two elongated peaks at frequencies of about 1640 cm−
1 and 1660 cm−
1,a similar split without divergence on the top of a peak at a frequency of about 1550 cm−
1 with a transformation into two elongated peaks at frequencies of about 1540 cm−
1 and 1560 cm−
1,a new peak at a frequency of about 1580 cm−
1, which is absent in norm,a dramatically enlarged peak at a frequency of about 1450 cm−
1 with a vertical line on the top (instead a normally presented peak at a frequency of about 1460 cm−
1),a sharp absorbance drop at a frequency of about 1480 cm−
1,a dramatically elongated peak at a frequency of about 1390 cm−
1 (instead a normally presented peak at a frequency of about 1410 cm−
1),whereby such presence indicating a state of rheumatic chorea.
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83. The method as in claim 68, further including a step of examining said region of said infrared absorbance spectra for the presence of:
-
a very elongated “
trapezium”
-like peak with a hollow cut top at a frequency range from about 1670 cm−
1 to about 1690 cm−
1 with a widened base, occupying the range from about 1600 cm−
1 to about 1740 cm−
1,a wide “
rectangular-trapezium”
-like peak with a “
wave”
-shaped top at a frequency range from about 1500 cm−
1 to about 1570 cm−
1 with a small peak on the top at a frequency of about 1545 cm−
1 and a wide base, occupying the range from about 1480 cm−
1 to about 1580 cm−
1,a small peak at a frequency of about 1450 cm−
1 and a little peak at a frequency of about 1470 cm−
1 (instead a normally presented peak at a frequency of about 1460 cm−
1),a flattened and widened peak at a frequency of about 1390 cm−
1 with a wide base, occupying the range from about 1390 cm−
1 to about 1400 cm−
1,a reduction of the ratio of the peak at about 1390 cm−
1 to the peak at about 1460 cm−
1 to about 0.4 (in norm-1.0),whereby such presence indicating a state of severe brain damage in a developmentally disabled blind infant with physical and mental retardation in one year after a postnatal head injury.
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84. The method as in claim 2, further including a step of examining a region of said infrared absorbance spectra in a frequency range from about 3000 cm−
- 1 to about 3100 cm−
1, especially of a peak at a frequency of about 3060 cm−
1, for a presence of deviations from said normal infrared absorbance spectra, said presence indicating a state of chronic infection.
- 1 to about 3100 cm−
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85. The method as in claim 84, further including a step of examining said region of said infrared absorbance spectra for a presence of reduction in the infrared absorbance in the range from about 3000 cm−
- 1 to about 3100 cm−
1, especially of a peak at a frequency of about 3060 cm−
1, in such a way that the ratio of the height for the rising line to that of a subsequently declining line drops to about 2 (in norm-5;
for other chronic infections 2.5-4.5), whereby such reduction indicating a state of pulmonary tuberculosis.
- 1 to about 3100 cm−
Specification