Apparatus and method for eliminating dislodged thrombus

• US 6,749,619 B2
• Filed: 11/20/2001
• Issued: 06/15/2004
• Est. Priority Date: 11/20/2001
• Status: Expired due to Fees

• Current Assignee: Cleveland Clinic Foundation
• Original Assignee: Cleveland Clinic Foundation
• Inventors: Greenberg, Roy K., Goodson, Harry B., Ouriel, Kenneth
• Primary Examiner(s): Casler, Brian L.
• Assistant Examiner(s): Kontos, Lina R
• Application Number:
  US09/989,813
• Publication Number:
  US 20030097094A1
• Time in Patent Office: 938 Days
• Field of Search: 604/96.01, 604/104, 604/107, 604/105, 604/106, 604/108
• US Class Current: 606/200
• CPC Class Codes: A61F 2/013 Distal protection devices, i.e. devices placed distally in combination with another endovascular procedure, e.g. angioplasty or stenting
• CPC Class Codes: A61F 2002/016 made from wire-like elements
• CPC Class Codes: A61F 2002/018 made from tubes or sheets of material, e.g. by etching or laser-cutting
• CPC Class Codes: A61F 2230/0067 conical
• CPC Class Codes: A61F 2230/0076 ellipsoidal or ovoid
• CPC Class Codes: A61F 2230/008 paraboloidal
• CPC Class Codes: A61F 2230/0091 helically-coiled or spirally-coiled, i.e. having a 2-D spiral cross-section
• CPC Class Codes: A61F 2230/0093 Umbrella-shaped, e.g. mushroom-shaped
• CPC Class Codes: A61M 25/007 Side holes, e.g. their profiles or arrangements; Provisions to keep side holes unblocked

Abstract

An apparatus (10) for eliminating dislodged thrombus (78) in a blood vessel (12) comprises a catheter (72) having a plurality of infusion ports (90) and a filter (76) attached to the catheter for trapping the dislodged thrombus carried by blood flow in the blood vessel. The infusion ports (90) are disposed within the filter (76) and are operable to deliver a thrombolytic fluid to dissolve the dislodged thrombus (78) trapped in the filter (76).

Claims

1. Apparatus for insertion into a blood vessel for eliminating thrombus in the blood vessel, said apparatus comprising:

a primary thrombolytic fluid delivery system comprising a first group of infusion ports for delivering a first amount of thrombolytic fluid which chemically reacts with an initially whole thrombus structure to cause the thrombus structure to chemically breakdown into several thrombus fragments smaller than the initially whole thrombus structure, and

a secondary thrombolytic fluid delivery system, located axially spaced apart from the primary thrombolytic fluid delivery system, comprising a filter member for trapping the several thrombus fragments and a second group of infusion ports located in the filter member for delivering a second amount of thrombolytic fluid which chemically reacts with the several thrombus fragments to cause the several thrombus fragments to further chemically breakdown and completely dissolve in the filter member.

2. The apparatus according to claim 1, wherein the primary and secondary thrombolytic fluid delivery systems comprise relatively movable first and second tubular members for insertion into the blood vessel.

3. The apparatus according to claim 1 wherein the primary thrombolytic fluid delivery system comprises the only means for loosening and separating the whole thrombus structure into several thrombus fragments.

4. The apparatus according to claim 1 wherein the filter member is radially expandable to stretch across the blood vessel and trap the several thrombus fragments carried by blood flowing through the blood vessel.

5. The apparatus according to claim 2 wherein the first and second groups of infusion ports are spaced along an infusion section of the respective first and second tubular members in a helical pattern.

6. The apparatus according to claim 1 wherein the first and second groups of infusion ports can deliver the thrombolytc fluid at a rate of up to 60 cc/hr.

7. The apparatus according to claim 2 wherein the first and second groups of infusion ports vary in size and increase in diameter toward a distal end of the first and second tubular members.

8. The apparatus according to claim 1 wherein the filter member comprises a mesh basket having a proximal end that has a relatively loose mesh to allow blood carrying the dislodged thrombus to enter the filter member and a distal end that has a relatively tight mesh to trap the several thrombus fragments as the blood flows through the filter member.

9. The apparatus according to claim 1 wherein the filter member has a distal end comprising a basket and a proximal end comprising support wires for supporting the basket.

10. The apparatus according to claim 1 wherein the filter member comprises at least one coil member that, when expanded, has a generally conical shape.

11. A method for intravascularly eliminating thrombus attached to a wall of a blood vessel, the method comprising the steps of:

inserting a primary and a secondary thrombolytic fluid delivery system into the blood vessel, the secondary thrombolytic fluid delivery system including a filter basket located downstream from the thrombus and downstream from the primary thrombolytic fluid delivery system;

delivering a first amount of thrombolytic fluid from the primary thrombolytic fluid delivery system to cause the thrombus structure to chemically breakdown into several thrombus fragments smaller than the initially whole thrombus structure;

trapping the several thrombus fragments in the filter basket;

delivering a second amount of thrombolytic fluid from the secondary thrombolytic fluid delivery system to cause the several thrombus fragments to further chemically breakdown and completely dissolve in the filter basket;

collapsing the filter basket; and

retracting the primary and secondary thrombolytic fluid delivery systems from the blood vessel without substantially any thrombus remaining within the filter basket.