Molecularly imprinted polymer solution anion sensor
First Claim
1. A sensor device for detecting an analyte comprising a molecularly imprinted polymer containing a chelated lanthanide, said chelated lanthanide comprising a lanthanide ion wherein said lanthanide ion is a europium or terbium ion, wherein the lanthanide ion is chelated with the polymerized derivate(s) of one or more ligands selected from the group consisting of vinyldibenzoylmethane, divinyldibenzoylmethane, vinyl-substituted 1,10-phenanthroline, and mixtures of two or more thereof, said chelated lanthanide capable of binding the analyte to be detected and having operatively associated therewith:
- a light source for generating excitation energy for said chelated lanthanide; and
a detector for detecting luminescent energy generated by said chelated lanthanide upon excitation.
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Accused Products
Abstract
Devices for measuring and detecting a wide variety of analytes, including polyatomic anions, such as organophosphorus pesticides and nerve agents are provided. The devices function by selectively binding an analyte to a luminescent functionality-imprinted copolymer. The copolymers possess a securely bound luminescent lanthanide ion, such as Eu3+, in a coordination complex that has been imprinted to bind the chemical functionality. Also provided are methods for producing the lanthanide-containing molecularly imprinted polymers of the invention.
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Citations
16 Claims
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1. A sensor device for detecting an analyte comprising a molecularly imprinted polymer containing a chelated lanthanide, said chelated lanthanide comprising a lanthanide ion wherein said lanthanide ion is a europium or terbium ion, wherein the lanthanide ion is chelated with the polymerized derivate(s) of one or more ligands selected from the group consisting of vinyldibenzoylmethane, divinyldibenzoylmethane, vinyl-substituted 1,10-phenanthroline, and mixtures of two or more thereof, said chelated lanthanide capable of binding the analyte to be detected and having operatively associated therewith:
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a light source for generating excitation energy for said chelated lanthanide; and
a detector for detecting luminescent energy generated by said chelated lanthanide upon excitation. - View Dependent Claims (2, 3, 4, 5, 9, 10, 11)
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6. A sensor device for detecting an analyte comprising a molecularly imprinted polymer containing a chelated lanthanide, said chelated lanthanide comprising a lanthanide ion wherein said lanthanide ion is a +3 europium ion, wherein the lanthanide ion is chelated with the polymerized derivate(s) of one or more ligands selected from the group consisting of vinyldibenzoylmethane, divinyldibenzoylmethane, vinyl-substituted 1,10-phenanthroline, and mixtures of two or more thereof, said chelated lanthanide capable of binding the analyte to be detected and having operatively associated therewith:
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a light source for generating excitation energy for said chelated lanthanide;
a detector for detecting luminescent energy generated by said chelated lanthanide upon excitation; and
at least one optical fiber, having a proximal end and a distal end, for transmitting light energy, wherein said molecularly imprinted polymer is disposed on the distal end of the optical fiber, said light source is operatively associated with said optical fiber such that said fiber is capable of transmitting excitation energy generated by the light source to said molecularly imprinted polymer, and said detector is operatively associated with said optical fiber such that said detector is capable of detecting luminescence from said chelated lanthanide. - View Dependent Claims (7, 8)
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12. A method of making a molecularly imprinted polymer comprising:
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mixing a lanthanide salt with one or more polymerizable lanthanide-coordinating ligand compounds and a polyatomic anion target analyte imprint molecule under conditions effective to produce a chelated lanthanide-analyte complex;
co-polymerizing the lanthanide-analyte complex with one or more cross-linking monomers, and one or more matrix monomers to form a polymer structure; and
removing the imprint molecule from the polymer structure to form an MIP. - View Dependent Claims (13, 14, 15, 16)
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Specification